Association Between the Serum Uric Acid Level and the Severity of Coronary Artery Disease in a Retrospective Study of China Nondialysis CKD Patients

Abstract

Introduction: Hyperuricemia has been associated with increased cardiovascular events in the general population. However, the role of serum uric acid (SUA) level on the severity of coronary artery stenosis (CAS) in nondialysis chronic kidney disease (CKD) patients is obscure. Methods: We implement a retrospective cohort study of 734 patients diagnosed with stage 3-5 CKD. All selected patients underwent coronary artery angiography. The associations of SUA with the present, and severity of coronary artery disease (CAD) were analyzed. Results: Of these 734 patients, 511 patients had angiographically proven CAD. Compared with non-CAD group, the SUA level in CAD group was much higher (388.00 vs. 363.00 mmol/l, P < 0.01). After adjusting for multiple confounding factors, a multivariate logistic regression analysis demonstrated that SUA was relevant to the presence of CAD when SUA as a continuous variable. However, this relationship was not observed with SUA as a categorical variable. In a subgroup analysis for the CAD group, we found that the rates of severe CAS in the third tertile of SUA (58.6%) was higher than that in the first tertile (41.6%) (P < 0.01). Compared with the first tertile of SUA, the third tertile of SUA was an independent risk factor for severe arterial stenosis (odds ratio, OR,), a pattern that was recapitulated by multivariate logistic regression analysis with SUA as a continuous variable (1.002 [1.000-1.004]). Conclusions: The SUA level may serve as a predictor of the severity of CAS among nondialysis CKD patients with CAD.

Serum Uric Acid and Coronary Arterial Disease in Predialysis Chronic Kidney Disease Patients

“…46 Recently, it has been reported that serum uric acid levels may serve as a predictor of the severity of coronary artery stenosis in nondialysis CKD patients with coronary disease. 47 In agreement, in our data we observed a significant unadjusted relationship between high serum uric acid and CAD occurrence. Furthermore, in this study coronary disease was significantly associated with vascular stiffness, low rate of renal function, and albuminuria.…”

The Correlation of Serum Uric Acid Levels With the Severity of Coronary Artery Disease in Diabetic Patients: A Cross-Sectional Study

“…In previous studies by Rahmani et al and Johnson et al, the authors noted a positive association between serum uric acid levels and the severity of CAD [ 12 , 13 ], similar to our study which also demonstrated a positive association. However, new research revealed that uric acid levels were a less accurate predictor of CAD severity [ 14 ].…”

Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease

“…In ESRD patients on peritoneal dialysis, thrombocytosis also appeared to be relevant to the severity of CAD and peripheral arterial disease assessed by Severity Index (24). A retrospective study in the Chinese non-dialysis patients with CKD concluded that serum uric acid level as a category variable was an independent risk factor for severe arterial stenosis and was associated with the risk of CAD as a continuous variable (25). Disturbance of the mineral metabolism particularly for biomarkers, such as serum calcium and phosphorus, can multiple cardiovascular disease and vascular calcification.…”