Uric acid and skin microvascular function

Wijnands, José M.A.; Houben, Alfons J.H.M.; Muris, Dennis M.J.; Boonen, Annelies; Schram, Miranda T.; Sep, Simone J. S.; Kallen, Carla; Henry, Ronald M.A.; Dagnelie, Pieter C.; Linden, Sjef van der; Schaper, Nicolaas C.; Arts, Ilja C. W.; Stehouwer, Coen D. A.

doi:10.1097/hjh.0000000000000583

Cited by 9 publications

(7 citation statements)

References 38 publications

(62 reference statements)

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“…Elevated UA could contribute to arteriolosclerosis of the renal afferent vessels and aggrevate inflammation, endothelial dysfunction of kidney, resulting in salt-sensitive hypertension [23]. UA may also influence skin microvascular function [24]. These effects exposed people to a higher susceptibility to arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults

Wang

Chu

et al. 2018

Kidney Blood Press Res

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Background/Aims: Elevated serum uric acid (UA) was intimately correlated with vascular stiffness and abnormal ankle brachial index (ABI) in various populations. These correlations lost significance after adjustment for estimated glomerular filtration rate (eGFR), indicating that the association of UA and brachial-ankle pulse wave velocity (baPWV) or ABI might be driven by kidney function. UA is predominantly eliminated through the kidneys, and metabolic disorders can influence the clearance of UA. In this study, we aimed to explore the putative correlation between FEUA and baPWV or ABI to determine to what extent the associations with UA were affected by renal function. Methods: This cross-sectional study enrolled 2351 participants, who underwent general health screening in Hanzhong people’s hospital from March to June of 2017. BaPWV and ABI were measured using a volume-plethysmographic apparatus (BP-203RPEII; Nihon Colin, Tokyo, Japan). FEUA was divided into quartiles: Q1:FEUA≤3.07; Q2: 3.07 9.19. Results: Lower FEUA predicted a higher prevalence of high baPWV and low ABI (p for trend <0.001). The respective ORs for high baPWV from the first to the third quartiles of FEUA were 1.777(1.323, 2.387); 1.561(1.158, 2.104); and 1.680 (1.250, 2.259). The prevalence of low ABI was greatly elevated with the decrement of FEUA [ORs for the first to third FEUA quartiles were 6.977(2.062, 23.610); 5.123(1.475, 17.790); and 2.685(0.709, 10.171), respectively]. The association of FEUA and ABI was independent of related confounding factors. However, the association between FEUA and baPWV was greatly influenced by corresponding confounders, especially gender. The efficacy of FEUA in the prediction of low ABI was stronger than that of serum UA. However, serum UA was more powerful in the prediction of high baPWV. Conclusion: Kidney function exerted a profound influence on the relationship between UA and baPWV or ABI, revealing complex interactions among cardiovascular risk factors.

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Section: Discussionmentioning

confidence: 99%

The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults

Wang

Chu

et al. 2018

Kidney Blood Press Res

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“…In addition to the in vitro studies, several cohort studies have consistently demonstrated that hyperuricemic subjects have impaired microvasculature in selected vascular beds, including in the coronary and retinal microvasculature . However, the recent Maastricht study, which evaluated microcirculation of the skin, found no evidence of a relation between uric acid levels and changes in dermal microvasculature of skin among the general population …”

Section: What Is Known and Objectivementioning

confidence: 99%

“…21,22 However, the recent Maastricht study, which evaluated microcirculation of the skin, found no evidence of a relation between uric acid levels and changes in dermal microvasculature of skin among the general population. 23 Despite a substantial body of evidence that implicates uric acid as a causal factor in microvascular dysfunction, less evidence prevails regarding the opposite, namely whether impairments in the microvasculature result in elevated uric acid levels. Supporting the latter, uric acid and/or its precursors are constantly produced by overtly ischaemic tissues and act as injury signals that activate the immune system and mobilize the endothelial progenitor cells following an acute ischaemic injury.…”

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

“…21,29 Contrastingly, a recent population-based study did not show any association between serum uric acid levels and pathological modifications in the dermal vasculature. 23 The group speculated that despite the systemic effects of hyperuricemia, variabilities in factors contributing to autoregulation in different vascular beds, especially the relatively more minor role of myogenic control in autoregulation of dermal microvasculature, could have resulted in such results.…”

Section: Meanwhile Dysfunctions In Retinal and Coronary Microcirculamentioning

confidence: 99%

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Elevation in serum uric acid levels predicts favourable response to erlotinib treatment in patients with metastatic non‐small‐cell lung cancer

et al. 2019

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What is known and objective Erlotinib is a small molecule tyrosine kinase inhibitor which blocks the activation of epidermal growth factor receptor (EGFR), a transmembrane receptor that is upregulated in many cancer types. Inhibition of angiogenesis with consequent impairments in intratumoral microcirculation is one of the mechanisms through which EGFR inhibition halts the progression of cancer. A consequence of impaired microcirculation is intratumoral hypoxia, which results in increases in serum uric acid levels. The goal of this study was to investigate the relationship between serum uric acid levels and response to erlotinib in metastatic non‐small‐cell lung cancer (NSCLC). Methods A total of 56 patients with metastatic non‐small‐cell lung cancer who received erlotinib for a duration of at least 3 months were included in this retrospective cohort study. Demographic characteristics, progression status, baseline serum uric levels and 3‐month serum uric acid levels were recorded and analysed. Results and discussion Of the study population, 21 (37.5%) were female and 35 (62.5%) were male patients. No significant difference in above demographic characteristics was observed among exitus, survivor with progression and survivor without progression groups. Patients who responded favourably to erlotinib with no progression of their disease had significantly increased uric acid levels at 3‐month follow‐up (P = .01). Such a correlation was not observed if the patient was exitus (P = .47) or had progressed on erlotinib therapy (P = .19). What is new and conclusion In conclusion, this study is the first to demonstrate significant increases in serum uric acid levels in patients with metastatic NSCLC who responded favourably to erlotinib and had no progression under erlotinib therapy. Further studies are required to confirm and characterize serum uric acid as a novel biomarker in predicting the outcome in those with metastatic NSCLC.

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“…Therefore, SUA attenuates generalized microvascular dysfunction in target organs, i.e. heart, lung and kidney, and suppresses a local inflammation in plaque (3,13). SUA may be an epigenetic regulator of vascular repair system through cooperating with mobbing and differentiation of endothelial progenitor cells and other cells' precursors (14).…”

Section: Introductionmentioning

confidence: 99%

The Controversial Role of Serum Uric Acid in Cardiovascular Diseases

Berezin¹

2017

Ulutas Med J

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Previous clinical, observation and epidemiologic studies have demonstrated strong association between serum uric acid (SUA) and cardiovascular disease (hypertension, heart failure, asymptomatic atherosclerosis), metabolic states (abdominal obesity, diabetes mellitus, metabolic syndrome, insulin resistance) and kidney disease. There is a large body of evidence regarding the role of SUA as predictor of CV events and CV mortality in general population and individuals with established CV disease and metabolic diseases. However, SUA may exhibit protective effects on endothelium and vasculature as well as attenuate endogenous repair system through mobbing and differentiation of cell precursors. Although SUA lowering drugs are widely used in patients with symptomatic hyperuricemia and gout beyond their etiologies, there is no agreement of SUA below target level 6 mg/dLin asymptomatic individuals with kidney injury and CV disease and data of ones are sufficiently limited. The short communication is depicted on the controversial role of SUA as primary cell toxicity agent and secondary cell protector against hypoxia, ischemia and apoptosis.

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Uric acid and skin microvascular function

Cited by 9 publications

References 38 publications

The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults

The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults

Elevation in serum uric acid levels predicts favourable response to erlotinib treatment in patients with metastatic non‐small‐cell lung cancer

The Controversial Role of Serum Uric Acid in Cardiovascular Diseases

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