“…This is in agreement with recent studies demonstrating an accumulation of porphyrins in atheromatous plaques. 19 Spokojny et al 22 have shown that HpD was selectively concentrated in different types of arterial lesions in the rabbit model, whereas the media of these tissues exhibited no fluorescence, indicating a decreased or complete lack of HpD uptake. Also Okunaka et al 20 have described in detail how HpD was concentrated in atheromatous lesions of the rabbit with characteristic peaks of the fluorescence at 630, 665, and 690 nm wavelengths after exposure to an excimer pulse dye laser, which was Although DHE is regularly used in combination with photoactivation by laser energy, the results of this study indicate that the application of DHE without photoactivation is also possible for a selective inhibition of plaque cell proliferation at concentrations that do not affect smooth muscle cells from nonatherosderotic arteries.…”