In vivo intravascular laser photodynamic therapy in rabbit atherosclerotic lesions using a lateral direction fiber

Clinical Potential of Photodynamic Therapy in Cardiovascular Disorders

“…[18][19][20]33,50,51] A number of experimental studies demonstrated the ability of PDT to reduce plaque size and prevent the progression of vascular disease in small and large animal models of atherosclerosis. [52][53][54] Atherosclerosis provides multiple targets for photodynamic therapy: infiltrating monocytes and macrophages, vasa vasorum, foam cells, cholesterol, and fatty acids. Intimal cells and endothelial cells in the plaque selectively undergo necrosis and disappear following PDT using hematoporphyrin derivative in rabbits.…”

“…Intimal cells and endothelial cells in the plaque selectively undergo necrosis and disappear following PDT using hematoporphyrin derivative in rabbits. [53] Interestingly, lipid components of the atheroma can also be affected by PDT. Indeed, a dissociation of ester bonds and the depletion of cholesterol esters in the atheromas of rabbits fed a cholesterol-rich diet for 20 weeks, were detected after PDT with mono-L-aspartyl chlorin e6.…”

Photodynamic Therapy for the Prevention of Intimal Hyperplasia in Balloon-Injured Rabbit Arteries

“…Reports have also been published on intravascular irradiation with intravascular probes as a new device for catheter intervention, based on the clinical application of PDT treatment of arteriosclerosis. 18,22 According to these reports, the short-term efficacy of PDT in experimental models was demonstrated by the inhibition of the intimal hyperplasia that occurs soon after balloon injury of blood vessels, and by the reduction in the intimal thickening that is found in arteriosclerotic foci.…”

“…[12][13][14][15][16][17] Our previous study investigated a novel approach using PDT with hematoporphyrin derivative (HPD), a photosensitizer, to treat intimal hyperplasia. 18,19 The present study was performed to demonstrate that HPD is preferentially localized and retained by intimal hyperplasia. We also used a light-diffusing catheter designed to irradiate both radially and axially over the length of atherosclerotic lesions to investigate whether HPD-sensitized PDT can selectively inhibit intimal hyperplasia.…”

Photodynamic Therapy of Atherosclerosis Using YAG-OPO Laser and Porfimer Sodium, and Comparison With Using Argon-Dye Laser

“…8 There have also been reports that when PDT is performed using the argon-dye laser intravascularly or extravascularly on aortic atherosclerosis in rabbits that had been administered HpD, there is regression or exfoliation of atheromatous intima, giving an enlarged lumen. 9,10 The Yttrium Aluminium Garnet-Optical Parametric Oscillated laser (YAG-OPO laser) was developed as a new PDT laser oscillator device. The tip output of a pulse laser is generally higher than that of a continuous laser, making possible efficient stimulation of the photosensitizer.…”