Upper respiratory tract in cystic fibrosis: Ear-nose-throat survey of 50 children

Histopathologic Features of the Temporal Bone in Patients With Cystic Fibrosis

“…5 Similar results have also been reported by Haddad et al 10 The lower than expected incidence of otitis media in patients with CF has been suggested to be due to the long-term administration of antibiotics for the treatment of respiratory tract infection. 3,11 In our series, patients were treated with long-term antibiotics but had a high incidence of sinusitis and a lower than expected incidence of otitis media, similar to the findings by Cuyler and Monaghan. 2 Although the use of ototoxic drugs resulted in damage to the inner ears of most of the temporal bones we studied, the idea that such drugs could prevent otitis media but not sinusitis seems unlikely.…”

“…1 The main clinical manifestations of CF in the upper respiratory tract system are sinusitis, rhinitis, and nasal polyposis. [1][2][3] Because the auditory tube and the middle ear are expanded portions of the upper respiratory tract system, several investigators have studied possible involvement of the middle ear in patients with CF.…”

ENaC- and CFTR-dependent ion and fluid transport in human middle ear epithelial cells

“…The adenosine 3 0 5 0 -cyclic monophosphate (cAMP)-dependent CFTR is the main pathway for luminal Cl À exit in airway epithelial cells, and its mutations cause airway inflammation such as pneumonia and sinusitis (Pilewski and Frizzell, 1999;Taylor et al, 1974). However, the incidence of middle ear infections in CF patients is lower Fig.…”

“…Among them, the CFTR acts as the main pathway of Cl À transport in airway epithelia. Furthermore, CFTR mutations cause periciliary fluid depletion, which results in severe airway diseases (Pilewski and Frizzell, 1999;Taylor et al, 1974). CaCC, which are activated by purinergic agonists such as ATP, are also known to be another major Cl À secretion pathway in airway epithelia (Tarran et al, 2002;Fuller and Benos, 2000).…”

The pathology of head and neck tumors: Nasal cavity and paranasal sinuses, part 5

“…In the younger patient, nasal polyps may precede clinical diagnosis of the disorder by several years. 27 There have been only a few reports attempting to provide histologic information as a basis for etiologic differentiation of polyps and, in short, there are no conclusive histologic findings that characterize nasosinal cystic fibrosis. The presence of large, mucous retention cysts with inspissated secretions and a hyperplasia of mucous glands is suggestive of but not restricted to cystic fibrosis ( fig.…”