Histopathologic Features of the Temporal Bone in Patients With Cystic Fibrosis

Yildirim, Nadir; Mutlu, Cemil; Schachern, Patricia A.; Paparella, Michael M.; Le, Chap T.

doi:10.1001/archotol.126.1.75

Cited by 19 publications

(18 citation statements)

References 24 publications

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“…They hypothesize that the mucosa of the auditory tube and the middle ear in CF patients is different in, for example, composition of goblet cells compared to non‐CF patients. Twelve years later this was confirmed by the results of Yildirim and coworkers . They performed histologic examination of the temporal bone of patients with CF and found lower densities of goblet cells in the mucosa of the auditory tube and middle ear of patients with CF compared to the middle ear mucosa and auditory tube of a non‐CF population.…”

Section: Discussionmentioning

confidence: 99%

“…Indirectly, however, the results of this study can be meaningful for clinicians treating patients with CF. A decreased TBP is an objective measure for a history of chronic ear infection . No difference in TBP between patients with mild CF and severe CF could indicate that these patients do not differ in middle ear pathology.…”

Section: Discussionmentioning

confidence: 99%

“…The pneumatization process starts at around 2 years of age and is completed between 10 and 15 years of age . Chronic middle ear infections can impede pneumatization of the temporal bone . Because the middle ear and the auditory tube are also lined with respiratory epithelium, viscous mucus and infection are expected to cause middle ear pathology in patients with CF.…”

Section: Introductionmentioning

confidence: 99%

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Temporal bone pneumatization in cystic fibrosis: A correlation with genotype?

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Temporal bone pneumatization in cystic fibrosis: A correlation with genotype?

et al. 2014

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“…Outra possível explicação é que pode haver diferentes expressões genéticas das mucinas no ouvido médio e na mucosa da árvore brônquica, o que pode contribuir para uma menor produção de muco nesses pacientes 7,8 . Além disso, Todd & Martin 9 supõem que o gene responsável pela formação correta da tuba auditiva está relacionado ao gene que determina a FC, e Choi et al 10 relataram que, na mucosa normal do ouvido médio, a expressão do regulador de condutância transmembrana em fibrose cística (CFTR) parece ser menos proeminente do que na mucosa nasal, e um canal de cloro induzido por ATP pode ser uma alternativa ao CFTR.…”

Section: Discussionunclassified

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Martins

Guimarães²,

Becker³

et al. 2011

J Pediatr (Rio J)

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Objective: To assess the prevalence of middle ear alterations in cystic fibrosis (CF) patients. Methods:In this descriptive study, 120 CF patients aged 5 months to 18 years were assessed by clinical history, otoscopy, and tympanometry. Data on P. aeruginosa colonization and parenteral and/or inhaled aminoglycoside use were also collected from medical charts. Results:Clinical history revealed absence of previous otitis media in 57% of patients. Tympanic membranes were normal in 94% of patients who underwent otoscopic evaluation; chronic otitis media was suggested in about 1% of the cases, otitis media with effusion (OME) in 2%, and Eustachian tube dysfunction in 3%. As for tympanometry, 91% of patients who underwent the exam showed normal results, OME was suggested in 2% of the cases, and Eustachian tube dysfunction in 7%. Conclusion:There was a low prevalence rate of middle ear alterations in our series of CF patients. The use of aminoglycosides and colonization by P. aeruginosa did not influence the prevalence of middle ear alterations. Our results suggest that a detailed clinical history and a routine otoscopy evaluation may confirm or rule out most middle ear alterations in CF patients.J Pediatr (Rio J). 2011;87(1):80-83: Cystic fibrosis, middle ear, tympanometry, tympanoscopy. ResumoObjetivo: Avaliar a prevalência de alterações do ouvido médio em pacientes com fibrose cística (FC). Métodos:Neste estudo descritivo, 120 pacientes com FC com idade entre 5 meses e 18 anos foram avaliados por meio do histórico clínico, da otoscopia e da timpanometria. Dados sobre a colonização por P. aeruginosa e uso de aminoglicosídeos por via parenteral e/ou inalatória também foram coletados a partir dos prontuários médicos.Resultados: O histórico clínico revelou ausência de otite média pré-via em 57% dos pacientes. As membranas timpânicas estavam normais em 94% dos pacientes que se submeteram a avaliação otoscópica; foi sugerida otite média crônica em cerca de 1% dos casos, otite média com derrame (OMD) em 2%, e disfunção da tuba auditiva em 3%. Quanto à timpanometria, 91% dos pacientes que se submeteram ao exame apresentaram resultados normais, foi sugerida OMD em 2% dos casos, e disfunção da tuba auditiva em 7%. Conclusão:Houve uma baixa taxa de prevalência de alterações do ouvido médio na nossa série de pacientes com FC. O uso de aminoglicosídeos e a colonização por P. aeruginosa não tiveram influência na prevalência das alterações do ouvido médio. Nossos resultados sugerem que um histórico clínico detalhado e uma avaliação otoscópica de rotina podem confirmar ou descartar a maior parte das alterações do ouvido médio em pacientes com FC.

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“…Reduced pneumatization of the temporal bone is evident in craniofacial disorders, including achondroplasia (Samuel, 1963;Shohat et al, 1993), Down syndrome (Glass et al, 1989;Imamura et al, 1996), Pierre-Robin syndrome (Handzic-Cuk et al, 1999) and Crouzon syndrome (Campos Del Alamo et al, 1999). One disease, cystic fibrosis, results in increased pneumatization of the temporal bone (Todd and Martin, 1988;Yildirim et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Ontogenetic Change in Temporal Bone Pneumatization in Humans

Hill

2011

The Anatomical Record

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Pneumatization of the temporal bone is often included in descriptions of fossils and as a phylogenetic marker, but a number of questions about the evolution, growth, and development of the trait remain. Many studies have analyzed temporal bone pneumatization from a clinical perspective, but a systematic quantification of normal development of pneumatized spaces has not been conducted. In this study, ontogenetic change in the size and organization of temporal bone pneumatization is analyzed in a cross-sectional sample of humans. High resolution computed tomography scans of the temporal bone were acquired from a cross-sectional sample of humans (N ¼ 28). Bone volume fractions, anisotropy, trabecular number, trabecular thickness, surface area, and volume were analyzed to provide information about the organization and size of pneumatized spaces across ontogeny. The results indicate that there are general and region-specific patterns of ontogenetic changes in the organization of pneumatized spaces. These changes reflect the transition from nonpneumatized bone to pneumatized bone. It also demonstrates that those regions that are pneumatized early in ontogeny (such as the mastoid antrum) continue to remodel after the initial period of pneumatization. The dynamic nature of temporal bone pneumatization over ontogeny suggests that this character requires careful consideration when used as a character for phylogenetic analyses. These results demonstrate the importance of comparing individuals from similar developmental stages, especially when completing quantitative analyses of the extent of pneumatization or organization of the spaces. Anat Rec, 294:1103Rec, 294: -1115Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Histopathologic Features of the Temporal Bone in Patients With Cystic Fibrosis

Abstract: Low densities of goblet cells in temporal bones with CF may contribute reduced amounts of viscous mucus, which can lead to a low incidence of otitis media.

Cited by 19 publications

References 24 publications

Temporal bone pneumatization in cystic fibrosis: A correlation with genotype?

Temporal bone pneumatization in cystic fibrosis: A correlation with genotype?

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Ontogenetic Change in Temporal Bone Pneumatization in Humans

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