Upper gastrointestinal findings and detection of <i>Helicobacter pylori</i> in patients with oral lichen planus

Attia, Enas A. S.; Fattah, Nermeen S. A. Abdel; Abdella, Heba M.

doi:10.1111/j.1365-2230.2009.03464.x

Cited by 26 publications

(28 citation statements)

References 20 publications

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“…In the case-control study by Moravvej et al, H. pylori frequency was found significantly higher using the urea breath test. 29 Our data does not strongly suggest the possible role of H. pylori in the etiopathogenesis of LP, while further evaluation on larger study groups may reveal more powerful results. 5,8 On the other hand, it was very close to the range reported for Turkish general population (67-81%).…”

Section: Discussioncontrasting

confidence: 76%

Investigation of upper gastrointestinal tract involvement and H. pylori presence in lichen planus: a case–controlled study with endoscopic and histopathological findings

İzol

Karabulut

Biyikoglu³

et al. 2010

Int J Dermatology

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We believe upper endoscopy should be performed to investigate esophageal LP and gastrointestinal pathologies especially when LP patient is symptomatic. Although we didn't detect esophageal LP, our study had the limitation of taking biopsies from pathological sites only. Since histopathological examination of normal appearing esophagus may help in diagnosing occult LP, and prevent eventual complications, it may be further evaluated in larger study groups. A new technique, magnification chromoendoscopy, may be useful in detecting esophageal involvement. We believe the possible role of H. pylori in LP is yet to be determined also.

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Section: Discussioncontrasting

confidence: 76%

Investigation of upper gastrointestinal tract involvement and H. pylori presence in lichen planus: a case–controlled study with endoscopic and histopathological findings

İzol

Karabulut

Biyikoglu³

et al. 2010

Int J Dermatology

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“…Attia et al in a study on 20 samples of upper gastrointestinal and erosive OLP detected the presence of H. pylori in 9 patients (45%) with erosive OLP. However, they did not find any association between OLP and H. pylori induced gastritis (15). It might be due to lack of a significant association between these two diseases.…”

Section: Discussionmentioning

confidence: 84%

Detection of Helicobacter pylori in Oral Lichen Planus and Oral Lichenoid Reaction

Irani¹,

Esfahani²,

Sabeti³

et al. 2014

Avicenna J Dent Res

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Background: Oral Lichen Planus (OLP) is a chronic inflammatory disease affecting the oral mucosa in 0.5-2% of the world's population. It is more common in women compared to men and the mean age at the onset of the lesion is the fourth decade. Objectives: The purpose of this study was to evaluate the presence of Helicobacter pylori (H. pylori) in Oral Lichen Planus and Oral Lichenoid Reaction. Materials and Methods: A total of 41 biopsies diagnosed as Oral Lichen Planus and Oral Lichenoid Reaction and 15 samples as the control group were selected from the archives of Pathology Department of Loghman Hakim Hospital, Tehran, Iran from 2002 to 2009. All the paraffin blocks were cut for hematoxylin and eosin (H and E) staining to confirm the diagnoses and the samples were then prepared for immunohistochemistry (IHC) staining. Statistical analysis was performed using SPSS statistical software (version 21.0), the chi-squared test and Fisher's exact test, and independent-samples t test. Statistical significance between the groups was set at P < 0.05. Results: The H. pylori positivity was found in 29.7% and 14.8% of OLP, and OLR samples, respectively. Statistically significant difference was not observed compared to normal tissues (P = 0.661). The chi-squared test show no significant difference between the frequency of H. pylori positivity and the lesion type, gender, and site. Although H. pylori positivity was found in 59.2%, and 50 % of OLP, and OLR samples, respectively, statistically significant difference was not observed compared to normal tissues (P = 0.838). In addition, the chi-squared test show no significant difference between the site of the lesion and H. pylori positivity. H. pylori positivity was mostly found on the buccal mucosa (64.3%), however, H. pylori negativity was mostly found on the tongue (60 %) (P = 0.309). Additionally, the chi-squared test show no significant difference between the frequency of H. pylori positivity, and the gender (P = 0.517). Independent-samples t test showed no statistically significant difference between age and two patient groups statistically (P = 0.450).Conclusions: This present study reveals no significant difference between the presence of H. pylori in OLPs and OLRs. Yet, further studies with larger sample size needs to be done to prove this association.

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“…Although OLP can be considered a result of bacterial pathogenesis or direct immune responses against bacterium which also affect mucosal tissue, as Attia et al, detected H. pylori DNA in oral lesions in all their patients with erosive OLP (Attia et al, 2010), an autoimmune-based mucosal destruction due to epitope spreading following the release of autoantigens from the injured cells after bacterial infection or antigenic mimicry between H. pylori and one of the antigens in mucosa membrane is more likely (Tchernev and Nenoff, 2009). In such conditions, neither the detection of H. pylori in the OLP lesions nor simultaneous gastric infection with this bacterium is essential in OLP formation as Taghavi Zenouz et al did not find any relationship between OLP and functional H. pylori infection by urease breath test (Taghavi Zenouz et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori (H. pylori) is involved in gastrointestinal lesions but its role in OLP is still suspicious (Attia et al, 2010), this study was designed to find any probable association between H. pylori infection and OLP in southwestern Iran. …”

Section: Introductionmentioning

confidence: 99%

Lack of Association Between Helicobacter pylori Infection and Oral Lichen Planus

Pourshahidi

Fakhri

Ebrahimi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Oral lichen planus is a premalignant chronic inflammatory mucosal disorder with unknown etiology. It is a multifactorial disease and in addition to genetic background, infections, stress, drug reactions are suggested as risk factors. Helicobacter pylori which is involved in development of many gastrointestinal lesions may also be implicated in oral lichen planus induction. This is of clear importance for cancer prevention and the present study was performed to determine any association between H. pylori infection and oral lichen planus in southwestern Iran. Anti H. pylori IgG levels were determined in 41 patients and 82 sex-age matched controls. The results showed no association between H. pylori infection and oral lichen planus (51% in patients vs. 66% in control). or any of its clinical presentations.

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Upper gastrointestinal findings and detection of Helicobacter pylori in patients with oral lichen planus

Cited by 26 publications

References 20 publications

Investigation of upper gastrointestinal tract involvement and H. pylori presence in lichen planus: a case–controlled study with endoscopic and histopathological findings

Investigation of upper gastrointestinal tract involvement and H. pylori presence in lichen planus: a case–controlled study with endoscopic and histopathological findings

Detection of Helicobacter pylori in Oral Lichen Planus and Oral Lichenoid Reaction

Lack of Association Between Helicobacter pylori Infection and Oral Lichen Planus

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