Investigation of upper gastrointestinal tract involvement and <i>H. pylori</i> presence in lichen planus: a case–controlled study with endoscopic and histopathological findings

İzol, Belçin; Karabulut, Ayşe Anıl; Biyikoglu, Ibrahim; Gönültaş, Mehmet Alpaslan; Ekşioğlu, Meral

doi:10.1111/j.1365-4632.2010.04541.x

Cited by 8 publications

(8 citation statements)

References 26 publications

(41 reference statements)

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“…Thyroid dysfunction is the most common associated disorder [76]. In a case-control study, superficial gastritis was significantly more common in LP patients than healthy controls [77]. Therefore, it is important to consider upper GI endoscopy particularly in LP patients with complaints of dysphagia, odynophagia, weight loss, or other esophageal symptoms and those with involvement of other mucosal surfaces [78].…”

Section: Resultsmentioning

confidence: 99%

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

Gorouhi

Davari

Fazel

2014

The Scientific World Journal

366

391

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Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. In this paper, we review the history, epidemiology, and clinical subtypes of LP. We also review the histopathologic aspects of the disease, differential diagnoses, immunopathogenesis, and the clinical and genetic correlations.

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Section: Resultsmentioning

confidence: 99%

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

Gorouhi

Davari

Fazel

2014

The Scientific World Journal

366

391

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“…Additionally, oxidative stress induced DNA damage could also lead to neoplastic changes, but the initial event leading to this signal cascade activation has not been characterized yet. Based on the increasing evidence viral, fungal, and bacterial antigens have all been suggested [26][27][28][29][30][31][32][33][34] as a potential initiating factor in LP. If there is a relationship between the bacterial flora and OLP, the question is whether the trigger area is in the oral cavity, or at another area of the body, such as the skin, the gastrointestinal tract, the larynx or the eyes.…”

Section: Introductionmentioning

confidence: 99%

Chicken or the Egg: Microbial Alterations in Biopsy Samples of Patients with Oral Potentially Malignant Disorders

Decsi

Sóki

Pap

et al. 2018

Pathol. Oncol. Res.

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Oral carcinogenesis often leads to the alteration of the microbiota at the site of the tumor, but data are scarce regarding the microbial communities of oral potentially malignant disorders (OPMDs). Punch biopsies were taken from healthy and non-healthy mucosa of OPMD patients to analyze the microbiome using metagenome sequencing. In healthy oral mucosa biopsies the bacterial phyla Firmicutes, Fusobacteria, Proteobacteria, Actinobacteria and Bacteroidetes were detected by Ion Torrent sequencing. The same phyla as well as the phyla Fibrobacteres and Spirochaetes were present in the OPMD biopsies. On the species level, there were 10 bacterial species unique to the healthy tissue and 35 species unique to the OPMD lesions whereas eight species were detected in both samples. We observed that the relative abundance of Streptococcus mitis decreased in the OPMD lesions compared to the uninvolved tissue. In contrast, the relative abundance of Fusobacterium nucleatum, implicated in carcinogenesis, was elevated in OPMD. We detected markedly increased bacterial diversity in the OPMD lesions compared to the healthy oral mucosa. The ratio of S. mitis and F. nucleatum are characteristically altered in the OPMD lesions compared to the healthy mucosa.

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“…In both the UKB and the PMBB, we observed a clear enrichment of oesophageal, gastric and upper gastrointestinal PheCodes. However, their occurrence seems to be lower than in previously published studies 5,7 . Because the published data stem from small, single‐centre reports from tertiary centres, it is conceivable that they are skewed towards more severe cases with multi‐organ involvement.…”

Section: Discussionmentioning

confidence: 66%

Comorbidities in lichen planus by phenome-wide association study in two biobank population cohorts

Fromme

Schneider

Schlapbach

et al. 2022

British Journal of Dermatology

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Background Lichen planus (LP) is a relatively frequent mucocutaneous inflammatory disease affecting the skin, skin appendages and mucosae, including oral mucosae, and less frequently the anogenital area, conjunctivae, oesophagus or larynx. Objectives To estimate the association of LP, with emphasis on dermatological and gastrointestinal conditions, in two large independent population cohorts. Materials and methods We performed a phenome-wide association study (PheWAS) and examined conditions associated with LP in two unrelated cohorts, i.e. the multicentre, community-based UK Biobank (UKB: 501 381 controls; 1130 LP subjects) and the healthcare-associated Penn Medicine BioBank (PMBB; 42 702 controls; 764 LP subjects). The data were analysed in 2021. The 'PheWAS' R package was used to perform the PheWAS analyses and Bonferroni correction was used to adjust for multiple testing. Odds ratios (ORs) were adjusted for age, sex and body mass index. Results In the UKB, PheWAS revealed 133 phenome codes (PheCodes) significantly associated with LP and most of them were confirmed in PMBB. Dermatological and digestive PheCodes were the most abundant: 29 and 34 of these disorders, respectively, were significantly overrepresented in LP individuals from both cohorts. The 29 dermatological and 12 oral disorders were often highly enriched, whereas hepatic, gastric, oesophageal and intestinal PheCodes displayed ORs in the range of 1Á6-4Á5. Several autoimmune disorders also exhibited OR > 5 in both cohorts. Conclusions PheWAS in two large unrelated cohorts identified previously unknown comorbidities and may support clinical counselling of patients with LP.What is already known about this topic?• Lichen planus (LP) is known to affect the skin, skin appendages and mucosae, including oral mucosae, and less frequently the anogenital area, conjunctivae, oesophagus or larynx.

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Investigation of upper gastrointestinal tract involvement and H. pylori presence in lichen planus: a case–controlled study with endoscopic and histopathological findings

Cited by 8 publications

References 26 publications

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

Chicken or the Egg: Microbial Alterations in Biopsy Samples of Patients with Oral Potentially Malignant Disorders

Comorbidities in lichen planus by phenome-wide association study in two biobank population cohorts

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