Update on the prevention and control of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA)

Skov, Robert; Christiansen, Keryn; Dancer, S.J.; Daum, Robert S.; Dryden, Matthew; Huang, Yhu-Chering; Lowy, Franklin D.

doi:10.1016/j.ijantimicag.2011.09.029

Cited by 72 publications

(41 citation statements)

References 94 publications

(112 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The clinical importance of S. aureus has grown particularly because of the increased occurrence of serious infections caused by methicillin-resistant S. aureus (MRSA) 2 , which are among the most frequent bacteria in healthcare-associated infections (HAIs) 3 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of constitutive and inducible resistance to clindamycin in clinical samples of Staphylococcus aureus from a tertiary hospital

Bottega

Rodrigues

Carvalho

et al. 2014

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have become common in hospitals and the community environment, and this wide resistance has limited patient treatment. Clindamycin (CL) represents an important alternative therapy for infections caused by S. aureus. Antimicrobial susceptibility testing using standard methods may not detect inducible CL resistance. This study was performed to detect the phenotypes of resistance to macrolides-lincosamides-streptogramin B (MLS B ) antibiotics, including CL, in clinical samples of S. aureus from patients at a tertiary hospital in Santa Maria, State of Rio Grande do Sul, Brazil. Methods: One hundred and forty clinical isolates were submitted to the disk diffusion induction test (D-test) with an erythromycin (ER) disk positioned at a distance of 20mm from a CL disk. The results were interpreted according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI). Results: In this study, 29 (20.7%) of the 140 S. aureus samples were resistant to methicillin (MRSA), and 111 (79.3%) were susceptible to methicillin (MSSA). The constitutive resistance phenotype (cMLS B ) was observed in 20 (14.3%) MRSA samples and in 5 (3.6%) MSSA samples, whereas the inducible resistance phenotype (iMLS B ) was observed in 3 (2.1%) MRSA samples and in 8 (5.8%) MSSA samples. Conclusions: The D-test is essential for detecting the iMLS B phenotype because the early identifi cation of this phenotype allows clinicians to choose an appropriate treatment for patients. Furthermore, this test is simple, easy to perform and inexpensive.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of constitutive and inducible resistance to clindamycin in clinical samples of Staphylococcus aureus from a tertiary hospital

Bottega

Rodrigues

Carvalho

et al. 2014

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…However, the recent increase in the incidence of multidrug-resistant isolates such as hospital-acquired methicillinresistant S. aureus (HA-MRSA) and community-acquired MRSA (CA-MRSA) and the increased dominance of highly virulent clonal lineages that can cause aggressive disease have diminished the success of such therapeutic strategies (5)(6)(7)(8)(9)(10). A number of comprehensive reviews addressing the increased incidence of these infectious lineages have already been reported (5,6,(11)(12)(13). It is clear that S. aureus exhibits tremendous adaptability when confronted with aversive stimuli (i.e., antibiotics) and harsh environmental conditions (host tissues that deprive the organism of essential nutrients), allowing it to execute a highly pathogenic life-style.…”

mentioning

confidence: 99%

The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus

Alonzo

Torres

2014

Microbiol Mol Biol Rev

235

290

View full text Add to dashboard Cite

SUMMARY The ability to produce water-soluble proteins with the capacity to oligomerize and form pores within cellular lipid bilayers is a trait conserved among nearly all forms of life, including humans, single-celled eukaryotes, and numerous bacterial species. In bacteria, some of the most notable pore-forming molecules are protein toxins that interact with mammalian cell membranes to promote lysis, deliver effectors, and modulate cellular homeostasis. Of the bacterial species capable of producing pore-forming toxic molecules, the Gram-positive pathogen Staphylococcus aureus is one of the most notorious. S. aureus can produce seven different pore-forming protein toxins, all of which are believed to play a unique role in promoting the ability of the organism to cause disease in humans and other mammals. The most diverse of these pore-forming toxins, in terms of both functional activity and global representation within S. aureus clinical isolates, are the bicomponent leucocidins. From the first description of their activity on host immune cells over 100 years ago to the detailed investigations of their biochemical function today, the leucocidins remain at the forefront of S. aureus pathogenesis research initiatives. Study of their mode of action is of immediate interest in the realm of therapeutic agent design as well as for studies of bacterial pathogenesis. This review provides an updated perspective on our understanding of the S. aureus leucocidins and their function, specificity, and potential as therapeutic targets.

show abstract

“…CA-MRSA is a significant public health burden and it is endemic in most countries [Som and Chatterjel 2013, Moellering 2006, Skov 2012. In developing settings e.g.…”

Section: Introductionmentioning

confidence: 99%

Antibiogram of Methicillin- Resistant Staphylococcus aureus Isolates among Healthy Human Subjects in Oleh, South-Southern Nigeria

Anie¹,

Ugwu²,

Ibezim³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Update on the prevention and control of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA)

Cited by 72 publications

References 94 publications

Evaluation of constitutive and inducible resistance to clindamycin in clinical samples of Staphylococcus aureus from a tertiary hospital

Evaluation of constitutive and inducible resistance to clindamycin in clinical samples of Staphylococcus aureus from a tertiary hospital

The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus

Antibiogram of Methicillin- Resistant Staphylococcus aureus Isolates among Healthy Human Subjects in Oleh, South-Southern Nigeria

Contact Info

Product

Resources

About