Update on the management of cutaneous lupus erythematosus

Abstract

This paper reviews the latest treatments for cutaneous lupus erythematosus. It focuses on evidence-based guidance for the management of cutaneous lupus erythematosus, with identification of the strength of evidence available at this time. In addition, I have briefly reviewed the epidemiological aspects, diagnosis and evaluation of patients with cutaneous lupus erythematosus. This review reflects data available from the Cochrane Library, Medline, literature searches, and the experience of the author managing patients with cutaneous lupus erythematosus for over 25 years.

Discoid lupus erythematosus at the vermilion border of the lip: A rare clinical presentation

“…Sunscreen cream or lotion to applied regularly topical therapy includes: (1) 0.025%, fluocinolone cream; (2) 0.1%, betamethasone 17-valerate cream; (3) 0.1%, triamcinolone acetonide cream; (4) intralesional corticosteroid injections -triamcinolone acetonide 5 -10 mg/ml at 6 weekly interval are helpful in resistant cases and interferon-α. [18,19] Oral therapy includes: 1. Oral prednisolone 0.5 mg/kg rapidly tapered over 6 weeks 2.…”

Cutaneous manifestations of systemic lupus erythematosus

“…Other medications that have been used empirically in subjects that were nonresponders to antimalarial therapy include oral retinoids, clofazimine, dapsone, azathioprine, methotrexate, mycophenolate mofetil, and other cytokineblocking medications. These medications also have doselimiting toxicities, including GI side effects, hepatotoxicity, neuropathy, malignancy, and bone marrow suppression [35].…”

Frequency of Systemic Lupus Erythematosus in Cutaneous Lupus Erythematosus

“…1 The types of skin lesions in each group are clinically distinct and recognizing the specific subsets helps in prognosticating the likelihood of underlying systemic lupus. 5 Over 80% of patients with systemic lupus have some form of cutaneous involvement during their course of illness. …”