2012
DOI: 10.1097/aci.0b013e3283551da5
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Update on systemic therapies for atopic dermatitis

Abstract: In light of the risk of hepatosplenic T-cell lymphomas, a greater degree of caution is warranted in the use of azathioprine. NBUVB, mycophenolate, and methotrexate remain the reasonable first-line systemic treatment options for atopic dermatitis. A brief run-in with high-dose cyclosporine to clear atopic dermatitis followed by maintenance with low-dose cyclosporine or cellcept - both of which have better risk and benefit ratios is a reasonable approach. Interferon gamma and intravenous immunoglobulin, although… Show more

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Cited by 42 publications
(27 citation statements)
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“…Recent studies within this research area focused either only on quality of life and cost comparisons between some single therapy options, or gave overviews about possible treatments [6,8,12,13,14,15,16,17]. …”
Section: Introductionmentioning
confidence: 99%
“…Recent studies within this research area focused either only on quality of life and cost comparisons between some single therapy options, or gave overviews about possible treatments [6,8,12,13,14,15,16,17]. …”
Section: Introductionmentioning
confidence: 99%
“…[25] Atopic Dermatitis Various studies have demonstrated the beneficial effects of MTX in adult atopic dermatitis. [26][27][28][29][30] It has emerged as one of the systemic drugs of choice in adult atopic dermatitis. [30] However, there is limited data demonstrating its use in children and adolescents.…”
Section: Psoriasismentioning
confidence: 99%
“…[26][27][28][29][30] It has emerged as one of the systemic drugs of choice in adult atopic dermatitis. [30] However, there is limited data demonstrating its use in children and adolescents. There is a case report of a 5-year-old boy with generalized atopic dermatitis who failed treatment with cyclosporine.…”
Section: Psoriasismentioning
confidence: 99%
“…Systemic treatment options include cyclosporine, corticosteroids, azathioprine and methotrexate [5], [6]. Cyclosporine and prednisolone are appropriate as short-term treatments [5], the former being nephrotoxic and the latter predisposing to osteoporosis, hypertension and other side-effects [7]. Cyclosporine is also almost entirely metabolized by the liver cytochrome P450 IIIA system, and clinically significant sustained drug-drug interactions can occur during long-term therapy [8].…”
Section: Introductionmentioning
confidence: 99%