Update on Chitosan-Based Hydrogels: Preparation, Characterization, and Its Antimicrobial and Antibiofilm Applications

Thirupathi, Kokila; Raorane, Chaitany Jayprakash; Vanaraj, Ramkumar; Ulagesan, Selvakumari; Moorthy, Madhappan Santha; Raj, Vinit; Krishnakumar, Gopal Shankar; Phan, Thi Tuong Vy; Kim, Seong-Cheol

doi:10.3390/gels9010035

Cited by 38 publications

(26 citation statements)

References 106 publications

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“…[25,42,49] By affecting the presence of toxic residual chemicals or the degree of swelling of the polymer matrix, the biocompatibility of hydrogels can be tuned as well by tuning preparation methods. For the treatment of DFU, hydrogel wound dressing can usually be prepared using different methods, including physical, chemical, and hybrid methods, [7,50,51] as schematically exemplified in Figure 2 and Figure 3.…”

Section: Preparation Methodsmentioning

confidence: 99%

Section: Hyaluronic Acidmentioning

confidence: 99%

Section: Hydrogels As Wound Dressing For Diabetic Foot Ulcersmentioning

confidence: 99%

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Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

Ko¹,

Liao

2023

BMEMat

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Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings are three‐dimensional networks of hydrophilic polymers that can absorb and retain large amounts of water, and have been shown to possess excellent biocompatibility, low toxicity, and excellent fluid handling properties. In addition, hydrogels create a moist wound environment that promotes wound healing by supporting cell proliferation, migration, and angiogenesis. Hydrogels, therefore, have emerged as promising wound dressings for promoting DFU healing. In this review, we attempt to chart the landscape of the emerging field of hydrogel as wound dressing for DFU treatment. We will explicitly review the assorted preparation methods for DFU hydrogels as well as a detailed discussion of various types of hydrogels deployed for DFU study. We also crystallize key findings, identify remaining challenges, and present an outlook on the future development of this enticing field.

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Section: Preparation Methodsmentioning

confidence: 99%

Section: Hyaluronic Acidmentioning

confidence: 99%

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Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

Ko¹,

Liao

2023

BMEMat

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“…These functional groups in the copolymer structure improve the copolymer's ability to behave as a nanocarrier. The copolymer structure's hydrophobic and hydrophilic segments may form a core-shell structure, and the polymeric nanoparticles maintain their structure even at low concentrations below the critical micelle concentration of micelles [36,37]. These copolymer nanocarriers can considerably improve drug targeting to specific regions due to the inclusion of stimuli-responsive functional groups in the copolymer structure.…”

Section: Stimuli-responsive Drug Delivery Behavior Of the Pnipaam-co-...mentioning

confidence: 99%

L-Lysine-Modified pNIPAm-co-GMA Copolymer Hydrogel for pH- and Temperature-Responsive Drug Delivery and Fluorescence Imaging Applications

Moorthy

Vanaraj

Thirupathi³

et al. 2023

Gels

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The development of dual-stimuli-responsive hydrogels attracts much research interest owing to its unique stimuli-responsive characteristics. In this study, a poly-N-isopropyl acrylamide-co-glycidyl methacrylate-based copolymer was synthesized by incorporating N-isopropyl acrylamide (NIPAm) and a glycidyl methacrylate (GMA) monomer. The synthesized copolymer, pNIPAm-co-GMA was further modified with L-lysine (Lys) functional units and further conjugated with fluorescent isothiocyanate (FITC) to produce a fluorescent copolymer pNIPAAm-co-GMA-Lys hydrogel (HG). The in vitro drug loading and dual pH- and temperature-stimuli-responsive drug release behavior of the pNIPAAm-co-GMA-Lys HG was investigated at different pH (pH 7.4, 6.2, and 4.0) and temperature (25 °C, 37 °C, and 45 °C) conditions, respectively, using curcumin (Cur) as a model anticancer drug. The Cur drug-loaded pNIPAAm-co-GMA-Lys/Cur HG showed a relatively slow drug release behavior at a physiological pH (pH 7.4) and low temperature (25 °C) condition, whereas enhanced drug release was achieved at acidic pH (pH 6.2 and 4.0) and higher temperature (37 °C and 45 °C) conditions. Furthermore, the in vitro biocompatibility and intracellular fluorescence imaging were examined using the MDA-MB-231 cell line. Therefore, we demonstrate that the synthesized pNIPAAm-co-GMA-Lys HG system with temperature- and pH-stimuli-responsive features could be promising for various applications in biomedical fields, including drug delivery, gene delivery, tissue engineering, diagnosis, antibacterial/antifouling material, and implantable devices.

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“…The most common way to make nanoparticles is through a process called "ionic gelation" (Hoang et al, 2022). Mixing chitosan polymer with sodium tripolyphosphate polyanion is one example of the ionic gelation method (Thirupathi et al, 2022). This causes the positive charge on the amino group of the chitosan to interact with the negative charge of the tripolyphosphate (Kim et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Formulation of a Gel Containing Asiaticoside from Pegagan (Centella asiatica l.) and Curcumin Isolate from Turmeric (Curcuma longa l.) as a Nano Medicine Particle Delivery System

Agusti

Tuba

2023

Preprint

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Pegagan (Centella asiatica) and turmeric (Curcuma longa) have a chemical that has been identified and utilized for wound healing. The study looked into how to make a gel with asiaticoside extract from Pegagan and curcumin isolate from turmeric and a nanoparticle delivery system to heal wounds caused by exercise and surgery. The rhizomes of pegagan and turmeric were taken out to make a gel preparation with a nanoparticle delivery system. Also, the extract was standardized and turned into nanoparticles. Finally, the gel preparation formula was made. Asiaticoside and curcumin gel nanoparticles were made by adding chitosan to a 0.1% sodium tripolyphosphate solution. Furthermore, physical examination and gel stability testing were performed on the three gel formulations with varying concentrations of NaCMC, such as 5%, 3%, and 15%. Asiaticoside nanoparticles had a size of 83.87 nm, while curcumin nanoparticles had a size of 62 nm, according to the results of the nanoparticle characterization. The viscous test for gel formulations employs gel viscosity standards of 80.000 (F1) cp, 34.000 cp (F2), and 3.600 cp (F3). The gel is stable for 30 days due to its organoleptic value and viscosity. Based on the results of a physical exam, Formula 3 is the best way to make a gel preparation with asiaticoside and curcumin nanoparticles.

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Update on Chitosan-Based Hydrogels: Preparation, Characterization, and Its Antimicrobial and Antibiofilm Applications

Cited by 38 publications

References 106 publications

Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

L-Lysine-Modified pNIPAm-co-GMA Copolymer Hydrogel for pH- and Temperature-Responsive Drug Delivery and Fluorescence Imaging Applications

Formulation of a Gel Containing Asiaticoside from Pegagan (Centella asiatica l.) and Curcumin Isolate from Turmeric (Curcuma longa l.) as a Nano Medicine Particle Delivery System

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