Formulation of a Gel Containing Asiaticoside from Pegagan (Centella asiatica l.) and Curcumin Isolate from Turmeric (Curcuma longa l.) as a Nano Medicine Particle Delivery System

Abstract

Pegagan (Centella asiatica) and turmeric (Curcuma longa) have a chemical that has been identified and utilized for wound healing. The study looked into how to make a gel with asiaticoside extract from Pegagan and curcumin isolate from turmeric and a nanoparticle delivery system to heal wounds caused by exercise and surgery. The rhizomes of pegagan and turmeric were taken out to make a gel preparation with a nanoparticle delivery system. Also, the extract was standardized and turned into nanoparticles. Finally, the gel preparation formula was made. Asiaticoside and curcumin gel nanoparticles were made by adding chitosan to a 0.1% sodium tripolyphosphate solution. Furthermore, physical examination and gel stability testing were performed on the three gel formulations with varying concentrations of NaCMC, such as 5%, 3%, and 15%. Asiaticoside nanoparticles had a size of 83.87 nm, while curcumin nanoparticles had a size of 62 nm, according to the results of the nanoparticle characterization. The viscous test for gel formulations employs gel viscosity standards of 80.000 (F1) cp, 34.000 cp (F2), and 3.600 cp (F3). The gel is stable for 30 days due to its organoleptic value and viscosity. Based on the results of a physical exam, Formula 3 is the best way to make a gel preparation with asiaticoside and curcumin nanoparticles.