Upconversional Nanoprobes with Highly Efficient Energy Transfer for Ultrasensitive Detection of Alkaline Phosphatase

Gao, Mengping; Wu, Ruiying; Mei, Qingsong; Zhang, Cuilan; Xiao, Ling; Deng, Shengsong; He, Hongmei; Zhang, Yong

doi:10.1021/acssensors.9b00858

Cited by 35 publications

(20 citation statements)

References 30 publications

(41 reference statements)

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“… 51 Upconversion nanoprobes with external luminescence quenchers are expected to be used for viral RNA detection due to their high energy transfer efficiency. 52 Carbon nanotube-based sensors have demonstrated the potential of viral optical detection without purification, amplification, and labeling. 53 Nanoparticles fabricated or printed on a 3D structure and functionalized with PNA or DNA efficiently capture SARS-CoV-2 RNA, where single molecule or signal amplification cascade enables the ultrasensitive label-free detection.…”

Section: Diagnostic Approaches To Covid-19mentioning

confidence: 99%

Current and Perspective Diagnostic Techniques for COVID-19

et al. 2020

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Since late December 2019, the coronavirus pandemic (COVID-19; previously known as 2019-nCoV) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been surging rapidly around the world. With more than 1,700,000 confirmed cases, the world faces an unprecedented economic, social, and health impact. The early, rapid, sensitive, and accurate diagnosis of viral infection provides rapid responses for public health surveillance, prevention, and control of contagious diffusion. More than 30% of the confirmed cases are asymptomatic, and the high false-negative rate (FNR) of a single assay requires the development of novel diagnostic techniques, combinative approaches, sampling from different locations, and consecutive detection. The recurrence of discharged patients indicates the need for long-term monitoring and tracking. Diagnostic and therapeutic methods are evolving with a deeper understanding of virus pathology and the potential for relapse. In this Review, a comprehensive summary and comparison of different SARS-CoV-2 diagnostic methods are provided for researchers and clinicians to develop appropriate strategies for the timely and effective detection of SARS-CoV-2. The survey of current biosensors and diagnostic devices for viral nucleic acids, proteins, and particles and chest tomography will provide insight into the development of novel perspective techniques for the diagnosis of COVID-19.

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Section: Diagnostic Approaches To Covid-19mentioning

confidence: 99%

Current and Perspective Diagnostic Techniques for COVID-19

et al. 2020

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“…Near‐infrared (NIR) light‐excitable upconversion nanoparticles (UCNPs) represent one of such systems and attracted a lot of attention from researchers because of their unique ability to convert low‐energy exaction photons (NIR light) to high‐energy fluorescence (UV/visible light), actting as on‐demand energy transducers. [ 1–11 ] Such upconverted transducer was already demonstrated for applications related to photodynamic therapy (PDT), [ 12–18 ] drug delivery, [ 19–26 ] molecular detection, [ 27–31 ] optogenetics, [ 32–34 ] etc. On the other side, broader applications of UCNPs are hindered by their low extinction coefficients and quantum efficiency as well as fixed energy levels.…”

Section: Introductionmentioning

confidence: 99%

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mentioning

confidence: 99%

Self‐Assembly of Upconversion Nanoparticles Based Materials and Their Emerging Applications

Zhang

Chen

Zhang

2021

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to photodynamic therapy (PDT), [12][13][14][15][16][17][18] drug delivery, [19][20][21][22][23][24][25][26] molecular detection, [27][28][29][30][31] optogenetics, [32][33][34] etc. On the other side, broader applications of UCNPs are hindered by their low extinction coefficients and quantum efficiency as well as fixed energy levels. [1,[35][36] Moreover, various energy transfer paths among these lanthanide cations often result in deleterious cross-relaxations. Thus, specific multiplexed applications require compositional and structural UCNPs design to be delicate and complex. The creation of such structures is multi-step and timeconsuming. [7,19,[37][38][39][40][41] To resolve these problems, scientists tried to develop UCNPs assemblies containing various UCNPs or UCNPs and other functional counterparts. The resulting composites exhibited unique properties, determined by the dimension and morphology of the individual components and the whole assembly. These properties can also be tuned depending upon the application situation such as dual-modality cell imaging, [26,[42][43] drug delivery, [44][45][46][47][48][49] molecular detection, [50][51] and programmed control therapy. [47][48] In terms of multifunctionality, the UCNPs assembly not only preserve the original upconverting characteristics of UCNPs but also endowed with variable other functional properties with much improved. All these properties help to improve performance and overcome the limitations of UCNPs. The composition, morphology, and assembly manner of individual components can be tuned to obtain the desired properties and adjust them to the specific environment when needed. Combining UCNPs with other materials (quantum dots, [43] metals, [51] polymers, [52][53] DNA, [26,42,54] etc.) minimizes the challenges connected to the UCNPs implementation allowing the resulting materials to exhibit multifunctionalities. These approaches made the composites containing UCNPs very promising for a variety of applications.Recently, a variety of UCNPs assembly synthesis methods was developed, which involve interface, [55][56][57] microemulsion, [52,[58][59] and polymer/DNA [26,46,60] meditated method. Meanwhile, it is not hard for us to observe the appearance of UCNPs assembly in some new applied fields such as DNA detection, [50][51] chemo-photodynamic therapy, [53,60] and programmable therapeutics. [45,[47][48] A grasp of the achievements on the UCNPs assembilies reported over the last years would assist scientists to fully utilize the UCNPs based nanoplatforms for various applications. Thus, Section 2 of this review describes UCNPs properties, and Sections 3 is dedicated to UCNPsIn the past few decades, significant progress of the conventional upconversion nanoparticles (UCNPs) based nanoplatform has been achieved in many fields, and with the development of nanoscience and nanotechnology, more and more complex situations need a UCNPs based nanoplatform having multifunctions for specific multimodal or multiplexed applications. Through self-assembly, different UCN...

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“…They are valuable and meaningful for overcoming many limitations such as high cost and long response time. Fluorescent probes developed for the detection of phosphatase based on the intermediate product phosphate [19] are surely feasible, but lack evidence of whether there are interferences from free phosphate. As typically reported, phosphate concentrations in adult human serum range from 0.81 to 1.45 mM [20,21].…”

Section: Introductionmentioning

confidence: 99%

A dual-signal fluorescent probe for detection of acid phosphatase

Wang

et al. 2021

Anal Bioanal Chem

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Acid phosphatase has become a significant indicator of prognostic and medical diagnosis, and its dysfunction may lead to a series of diseases. A novel dual-signal fluorescence method for acid phosphatase detection based on europium polymer (europiumpyridine dicarboxylicacid-adenine) and pyridoxal phosphate (PLP) was proposed. PLP coordinated with europium polymer via Eu 3+ and P-O bonds, and the fluorescence of europium polymer was quenched due to the photoinduced electron transfer (PET) effect between aldehyde and europium polymer. Upon addition of acid phosphatase, the PLP was transformed to phosphate (Pi) and pyridoxal (PL). The PL was released from the surface of europium polymer, and the blue emission was enhanced due to the formation of internal hemiacetal, while the fluorescence of europium polymer recovered. The blue (PL) and red emission (Eu 3+ ) were positively correlated with acid phosphatase activity; thus the sensitive assay of acid phosphatase was effectively achieved. The two signals were applied to determine the acid phosphatase with limits of detection (LOD) of 0.04 mU/mL and 0.38 mU/mL, and the linear ranges were 0.13-5.00 mU/mL and 1.25-20.00 mU/mL, respectively. The probe can be used to trace the acid phosphatase in biological systems and holds promise for use in clinical diagnosis and early prevention.

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Upconversional Nanoprobes with Highly Efficient Energy Transfer for Ultrasensitive Detection of Alkaline Phosphatase

Cited by 35 publications

References 30 publications

Current and Perspective Diagnostic Techniques for COVID-19

Current and Perspective Diagnostic Techniques for COVID-19

Self‐Assembly of Upconversion Nanoparticles Based Materials and Their Emerging Applications

A dual-signal fluorescent probe for detection of acid phosphatase

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