Up-regulation of lipogenic enzyme genes expression in inguinal white adipose tissue of female rats by progesterone

Stelmańska, Ewa; Świerczyński, Julian

doi:10.1016/j.jsbmb.2012.10.006

Cited by 16 publications

(20 citation statements)

References 43 publications

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“…It is worth noting that we likewise found no changes in gene expression in other organs of males treated with progesterone, unlike with females [4].…”

Section: Discussionsupporting

confidence: 41%

“…We have recently shown that progesterone influences metabolic and endocrine functions of white adipose tissue in female rats by regulating some genes expression [4,5]. We observed that progesteronetreated females, in contrast to males, eat more food than controls.…”

Section: Introductionmentioning

confidence: 66%

“…Some data suggests that progesterone may affect carbohydrates and lipids metabolism, organism growth, body composition and food intake [2,3]. Studies on rodents have demonstrated that progesterone treatment increases body weight and adipose tissue mass by regulation of the expression of specific genes [4]. It is well known that in pregnancy (upon high concentration of progesterone in blood) the most important regulatory process is the increase in appetite and food intake.…”

Section: Introductionmentioning

confidence: 99%

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Zwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu

Stelmańska

Sucajtys-Szulc²

2014

Endokrynologia Polska

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Enhanced food intake by progesterone-treated female rats is related to changes in neuropeptide genes expression in hypothalamusZwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu AbstractIntroduction: Progesterone-treated females eat more food, but the mechanism underlying this effect is not well understood. The aim of the study was to analyse the effect of progesterone on neuropeptide genes expression in rat hypothalamus. Material and methods: Experiments were carried out on female and male Wistar rats. Animals were treated with progesterone (100 mg per rat) for 28 days. NPY and CART mRNA levels in hypothalamus were quantified by real-time PCR. The serum progesterone concentration was determined by radioimmunoassay. Results: Progesterone administration to females caused an increase in food intake, body mass, and white adipose tissue mass. Elevated circulating progesterone concentration up-regulated NPY and down-regulated CART genes expression in hypothalamus of females. In males, elevated blood progesterone concentration had no effect on food intake, body and fat mass and on the neuropeptide genes expression in hypothalamus. Moreover, administration of progesterone in females resulted in decrease of PR mRNA level in hypothalamus. No effect of progesterone administration on PR mRNA level in hypothalamus of males was found. Conclusions: The changes in neuropeptide genes expression in hypothalamus may lead to stimulation of appetite and might explain the observed increase in food intake, body and adipose tissue mass in progesterone-treated females.

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“…It is worth noting that we likewise found no changes in gene expression in other organs of males treated with progesterone, unlike with females [4].…”

Section: Discussionsupporting

confidence: 41%

Section: Introductionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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Zwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu

Stelmańska

Sucajtys-Szulc²

2014

Endokrynologia Polska

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“…demonstrated that although the lipogenic effect of an obesogenic diet remained or was enhanced after previous progesterone administration, the metabolic, endocrine and adipose tissue dysfunction induced by diet could be prevented with high‐dose progesterone treatment. Furthermore, a specific stimulatory effect of progesterone on lipogenic enzyme gene expression in subcutaneous adipose tissue in female rats has been shown in a recent study . Adipose tissue also has the enzymatic machinery to inactivate progesterone .…”

Section: Introductionmentioning

confidence: 99%

Cross‐sectional associations of acylation stimulating protein (ASP) and adipose tissue gene expression with estradiol and progesterone in pre‐ and postmenopausal women

Rezvani

Gupta

Smith

et al. 2014

Clinical Endocrinology

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“…Thus, the progesterone‐releasing effect of cinnamon in the present study is likely to be related to the action of cinnamaldehyde. Interestingly, higher levels of progesterone have been associated with increased adipose mass and increased expression of lipogenic enzymes . However, lactating females supplemented with cinnamon exhibited a reduction in visceral adipose tissue mass.…”

Section: Discussionmentioning

confidence: 99%

Maternal cinnamon extract intake during lactation leads to sex‐specific endocrine modifications in rat offspring

et al. 2017

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Up-regulation of lipogenic enzyme genes expression in inguinal white adipose tissue of female rats by progesterone

Cited by 16 publications

References 43 publications

Zwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu

Zwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu

Cross‐sectional associations of acylation stimulating protein (ASP) and adipose tissue gene expression with estradiol and progesterone in pre‐ and postmenopausal women

Maternal cinnamon extract intake during lactation leads to sex‐specific endocrine modifications in rat offspring

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