Zwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu

Abstract

Enhanced food intake by progesterone-treated female rats is related to changes in neuropeptide genes expression in hypothalamusZwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu AbstractIntroduction: Progesterone-treated females eat more food, but the mechanism underlying this effect is not well understood. The aim of the study was to analyse the effect of progesterone on neuropeptide genes expression in rat hypothalamus. Material and methods: Experiments were carried out on female and male Wistar rats. Animals were treated with progesterone (100 mg per rat) for 28 days. NPY and CART mRNA levels in hypothalamus were quantified by real-time PCR. The serum progesterone concentration was determined by radioimmunoassay. Results: Progesterone administration to females caused an increase in food intake, body mass, and white adipose tissue mass. Elevated circulating progesterone concentration up-regulated NPY and down-regulated CART genes expression in hypothalamus of females. In males, elevated blood progesterone concentration had no effect on food intake, body and fat mass and on the neuropeptide genes expression in hypothalamus. Moreover, administration of progesterone in females resulted in decrease of PR mRNA level in hypothalamus. No effect of progesterone administration on PR mRNA level in hypothalamus of males was found. Conclusions: The changes in neuropeptide genes expression in hypothalamus may lead to stimulation of appetite and might explain the observed increase in food intake, body and adipose tissue mass in progesterone-treated females.

The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation

“…Progesterone and estrogen also exert opposite effects on food intake in vivo (Table 3 ). In particular, estrogen depresses food intake in part via induction of leptin production by adipose tissue, whereas progesterone increases food intake by enhancing NPY and reducing CART expression by the hypothalamus (Table 3 ; Fungfuang et al, 2013 ; Stelmanska and Sucajtys-Szulc, 2014 ). Estrogen and progesterone however seem to have similar effects on the pancreas; they both appear to induce islet hypertrophy and/or increase pancreatic insulin levels and glucose-stimulated secretion in vivo (Table 3 ; Costrini and Kalkhoff, 1971 ; Bailey and Ahmed-Sorour, 1980 ).…”

Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases

“…They also exert opposite effects on food intake and vascular physiology. Progesterone stimulates appetite and fat deposition, as well as neuropeptide-Y expression for vasoconstriction, whereas oestrogen promotes leptin-dependent satiety and vasodilatation [18]. Moreover, progesterone decreases cardiomyocyte apoptosis, and triggers metabolic shift from carbohydrate to lipid, as a main energetic substrate for the myocardium [19].…”

Proteomics of appetite-regulating system influenced by menstrual cycle and intensive exercise in female athletes: a pilot study

“…Estradiol directly stimulates anorexigenic neurons in the hypothalamus, reducing energy intake 3 , and also increases the secretion of cholecystokinin, a gut peptide hormone that stimulates anorexigenic neurons in the central nervous system, resulting in reducing appetite 4 – 7 . In contrast, progesterone suppresses the activity of anorexigenic neurons and stimulates the activity of orexigenic neurons, resulting in increasing energy intake 8 . It is worth noting that these two hormones tend to increase simultaneously during the luteal phase (following ovulation), and the complex interplay of their effects could have a notable impact on women's overall well-being.…”