Maternal cinnamon extract intake during lactation leads to sex‐specific endocrine modifications in rat offspring

Bento-Bernardes, Thais; Toste, Fabiane Pereira; Pazos‐Moura, Carmen C.; Oliveira, Karen Jesus

doi:10.1002/jsfa.8253

Cited by 6 publications

(3 citation statements)

References 58 publications

(136 reference statements)

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“…Cinnamon is a common spice that is used worldwide and has been widely studied as a nutraceutical for the management of insulin resistance, obesity and dyslipidemia (Rafehi et al 2012, Medagama 2015. According to the results of human, animal or in vitro studies, cinnamon and its active biological compounds interfere with the biosynthesis or action of many hormones, such as insulin, glucagon-like peptide-1 (GLP1), ghrelin and leptin (Hlebowicz et al 2009, Rafehi et al 2012, Camacho et al 2015, Lopes et al 2015, Medagama 2015, Bento-Bernardes et al 2017. In this context, a study showed that rats supplemented with a water extract of cinnamon exhibited lower serum T3 levels accompanied by unaltered serum T4 and TSH levels.…”

Section: Cinnamonmentioning

confidence: 99%

Thyroid function disruptors: from nature to chemicals

Oliveira

Chiamolera

Giannocco

et al. 2019

Journal of Molecular Endocrinology

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The modern concept of thyroid disruptors includes man-made chemicals and bioactive compounds from food that interfere with any aspect of the hypothalamus-pituitary-thyroid axis, thyroid hormone biosynthesis and secretion, blood and transmembrane transport, metabolism and local action of thyroid hormones. This review highlights relevant disruptors that effect populations through their diet: directly from food itself (fish oil and polyunsaturated fatty acids, pepper, coffee, cinnamon and resveratrol/grapes), through vegetable cultivation (pesticides) and from containers for food storage and cooking (bisphenol A, phthalates and polybrominated diphenyl ethers). Due to the vital role of thyroid hormones during every stage of life, we review effects from the gestational period through to adulthood, including evidence from in vitro studies, rodent models, human trials and epidemiological studies.

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Section: Cinnamonmentioning

confidence: 99%

Thyroid function disruptors: from nature to chemicals

Oliveira

Chiamolera

Giannocco

et al. 2019

Journal of Molecular Endocrinology

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“…It has long been used as a spice and in traditional herbal medicines. Available evidence suggests that cinnamon has beneficial effects on diabetes management [3]. Multiple mechanisms have been proposed by which cinnamon improves diabetes, including enhancing insulin sensitivity through insulin receptor signaling, inhibiting the activity of carbohydrate-digesting enzymes, inhibiting glucose transport, delaying gastric emptying, and blocking glucose absorption [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Liu,

Xing

et al. 2023

Foods

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The liver is the primary organ regulating glucose metabolism. In our recent study, cinnamon improved liver function in diabetic mice. However, it is not clear whether cinnamon can reduce the glycemia of diabetic animals by regulating liver glucose metabolism. The purpose of this study was to investigate the hypoglycemic mechanism of cinnamon powder (CP) from the perspective of regulating liver glucose metabolism. To achieve this, different doses of CP (200, 400, or 800 mg/kg body weight) were given to diabetic mice by gavage once per day for 8 weeks. These mice were compared with healthy controls, untreated diabetic mice, and diabetic mice treated with metformin (the main first-line drug for type 2 diabetes). CP treatment effectively reduced fasting blood glucose levels and food intake, improved glucose tolerance and fasting serum insulin levels, and decreased glycated serum protein levels in diabetic mice. Furthermore, treatment with CP increased liver glycogen content and reduced the level of the gluconeogenesis precursor pyruvate in the liver. Data obtained by qPCR and western blotting suggested that CP improved glucose metabolism disorders by regulating AMPKα/PGC1α-mediated hepatic gluconeogenesis and PI3K/AKT-mediated hepatic glycogen synthesis. CP exhibits good hypoglycemic effects by improving hepatic glycogen synthesis and controlling hepatic gluconeogenesis. Therefore, CP may be applied as a functional food to decrease blood glucose.

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“…Available evidence suggests that cinnamon has beneficial effects on diabetes management 27 . Multiple mechanisms have been proposed by which cinnamon improves diabetes, including enhancing insulin sensitivity through insulin receptor signaling, inhibiting the activity of carbohydrate-digesting enzymes, inhibiting glucose transport, delaying gastric emptying, and blocking glucose absorption 28 . The liver plays a crucial role in glucose metabolism.In fact, one study in 84 people with polycystic ovary syndrome (PCOS) found that taking 1,500 milligrams (mg) of cinnamon daily led to a significant increase in antioxidant blood levels after 8 weeks 29 .Antioxidants are important because they help the body reduce oxidative stress, a type of damage to cells that is caused by harmful free radicals 30 .One study showed that consuming 1 gram (g) of cinnamon extract daily for 12 weeks reduced fasting blood sugar levels and improved markers of oxidative stress in people with type 2 diabetes 31 .…”

Section: Cinnamonmentioning

confidence: 99%

Between Medicines and Nutraceuticals in the Control of Diabetes Mellitus

Park,

Baek

2024

Asian J Pharm Res Dev

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Diabetes is a type of metabolic disease such as insufficient insulin secretion or poor functioning. It is characterized by high blood sugar, which increases blood glucose concentration, causes various symptoms and signs due to high blood sugar, and excrete glucose from urine.Diabetes mellitus is divided into types 1 and 2, and type 1 diabetes was previously called 'juvenile diabetes', and it is a disease caused by the inability to produce any insulin. Type 2 diabetes, which is relatively deficient in insulin, is characterized by insulin resistance.Insulin treatment is required for type 1 diabetes, but type 2 diabetes is based on lifestyle correction and may require additional drug administration. In addition, many patients or people concerned about diabetes use dietary supplements to control their blood sugar, but because of the side effects of prescription drugs and the lack of definitive clinical trials of dietary supplements, it is important to choose wisely between prescription drugs and dietary supplements with the advice of a physician or expert to treat or prevent diabetes.

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Maternal cinnamon extract intake during lactation leads to sex‐specific endocrine modifications in rat offspring

Abstract: The present study demonstrates that maternal cinnamon intake during lactation promotes mild changes in dams and can trigger sex-specific metabolic programming in pups that lasts into adulthood. © 2017 Society of Chemical Industry.

Cited by 6 publications

References 58 publications

Thyroid function disruptors: from nature to chemicals

Thyroid function disruptors: from nature to chemicals

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Between Medicines and Nutraceuticals in the Control of Diabetes Mellitus

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