Up regulation of C3, C4, and soluble intercellular adhesion molecule-1 co-expresses with high sensitivity C reactive protein in familial hypoalphalipoproteinaemia: further evidence of inflammatory activation

Sampietro, Tiziana; Bigazzi, Federico; Pino, Beatrice Dal; Rossi, G. F.; Chella, E.; Lusso, S.; Puntoni, M.; Tuoni, M.; Bionda, A.

doi:10.1136/hrt.2003.017327

Cited by 9 publications

(9 citation statements)

References 21 publications

(10 reference statements)

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“…It has been previously reported that in RA, as well as in other inflammatory conditions, the presence of abnormally, pathologically elevated complement C3 levels may reflect the presence of an underlining inflammatory process (23). We can suggest that the relatively high amount of plasma C3 could be due to spill over from the joints probably reflecting an in situ over-expression or even to an abnormal production of complement proteins due to inflammation (24)(25). This could explain the reduction in complement C3 and C4 levels in the absence of complement activating cleavage fragments observed by us after treatment with TNF antagonists.…”

Section: Complement Disease Activity and Anti-tnf Treatmentmentioning

confidence: 89%

Complement System and Rheumatoid Arthritis: Relationships with Autoantibodies, Serological, Clinical Features, and Anti-TNF Treatment

Muzio

Perricone

Ballanti

et al. 2011

Int J Immunopathol Pharmacol

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The first two authors contributed equally to this work Autoantibodies (rheumatoid factor, RF; anti-citrullinated-protein antibodies,ACPA) and complement system are involved in rheumatoid arthritis (RA). ACPA and anti-TNF agents are capable of in vitro modulating complement activity. We investigated the relationships between complement, autoantibodies, and anti-TNF treatment in vivo. One-hundred fourteen RA patients (89F/25M), diagnosed according to 1987 ACR criteria, and 30 healthy controls were enrolled. Serological analysis included ESR, CRP, complement C3, C4 and CH50, RF and ACPA (ELISA, cut-off>20U/ml). Split-products (SP) of C3 and B were studied by immunoelectrophoresis/counterimmunoelectrophoresis. Seventy-six patients started anti-TNF treatment and were studied at baseline and after 22 weeks. Disease activity was measured with DAS28 and response to therapy with EULAR criteria. At baseline, RA patients showed significantly higher levels of C3 and C4 than controls (C3 127.9±26.5 vs 1l0±25mgldl, P=O.0012; C4 29.7±10.2 vs 22.7±8.3mgldl, P=0.0003). No differences in C3, C4 and CH50 levels were observed between ACPA+ (n=76) and ACPA-(n=38) patients. After 22 weeks of anti-TNF, C3, C4 and RF were significantly reduced (P<0.003, <0.005 and <0.04, respectively) and RF changes showed negative correlation with CH50. SP of C3 and B were observed neither at baseline nor after 22 weeks. DAS28 significantly improved after 22 weeks. Patients showing higher baseline C3 or lower reduction of C3 levels after 22 weeks had a worse EULAR outcome (x2=22.793, P

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Section: Complement Disease Activity and Anti-tnf Treatmentmentioning

confidence: 89%

Complement System and Rheumatoid Arthritis: Relationships with Autoantibodies, Serological, Clinical Features, and Anti-TNF Treatment

Muzio

Perricone

Ballanti

et al. 2011

Int J Immunopathol Pharmacol

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“…As C3 is associated with smoking status (Engstrom et al, 2005a), risk factors of obesity (Engstrom et al, 2005a), type 2 diabetes (Engstrom et al, 2005b), cardiovascular diseases (Onat et al, 2005) and several complications associated with inflammation (Kriketos et al, 2004) and inflammatory biomarkers (Halkes et al, 2001;Sampietro et al, 2004), C3 should be a good candidate as a marker of inflammation. However, we could not directly correlate smoking status neither physical activity with C3 concentrations although an effect of those variables was evident in our trial.…”

Section: Discussionmentioning

confidence: 99%

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

et al. 2008

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Objectives: To evaluate the associations between serum complement factor 3 (C3) and several anthropometrical, biochemical and lifestyle features in healthy young adults, emphasizing on the putative effect of selenium intake on C3 concentrations. Methods: This study enrolled 100 healthy young adults aged 18-34 years. Anthropometric and blood pressure measurements and lifestyle features were analyzed. Fasting blood samples were collected for the measurement of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerols and C3 concentrations. Nail samples were collected for the analysis of selenium concentrations. Results: Values of BMI (P ¼ 0.034), sum of skinfold thicknesses (STs) (P ¼ 0.021), body fat mass (BFM) (P ¼ 0.023), percentage of overweight subjects (P ¼ 0.007), serum triacylglycerols (P ¼ 0.012) and nail selenium (P ¼ 0.001) were significantly different between subjects above and below the median of serum C3 concentrations. The following correlations with serum C3 were identified tricipital ST (P ¼ 0.033), sum of STs (P ¼ 0.012), BMI (P ¼ 0.008), BFM (P ¼ 0.018), waist-to-height ratio (P ¼ 0.016), serum glucose (P ¼ 0.045), serum triacylglycerols (P ¼ 0.001) and nail selenium (P ¼ 0.006). Circulating C3 showed a positive association with several adiposity markers such as BMI (P ¼ 0.001), waist circumference (P ¼ 0.006), waist-to-height ratio (P ¼ 0.002), BFM (P ¼ 0.025), as well as serum glucose (P ¼ 0.027) and triacylglycerols (Po0.001), whereas nail selenium was a statistically significant negative predictor of C3 concentrations (P ¼ 0.018). Conclusions: C3 seems to be related with selenium status and several anthropometrical and biochemical measurements linked to metabolic syndrome in apparently healthy young adults. These findings suggest a possible role for selenium intake in the modulation of C3, whose assessment may be an early marker of metabolic syndrome manifestations.

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“…Patients with familial hypoalphalipoproteinaemia, a condition marked by low plasma levels of apoA-I and HDL-C and associated with increased risk for atherosclerosis, have elevated plasma concentrations of complement proteins C3 and C4, as well as, C reactive protein and the soluble cell adhesion molecule ICAM-1 (106). Similarly, Tangier disease patients, who have a mutation in ATP binding cassette transporter A1 (ABCA1) and, therefore, also have low HDL (107), have increase complement activity (108).…”

Section: Potential Roles For Protease Regulation By Hdlmentioning

confidence: 99%

High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis

Gordon

Remaley

2017

Atherosclerosis

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High density lipoproteins (HDL) represent a compositionally diverse population of particles in the circulation, containing a wide variety of lipids and proteins. Gene ontology functional analysis of the 96 commonly identified HDL binding proteins reveals that almost half of these proteins are either proteases or have known roles in protease regulation. Here, we discuss the activities of some of these proteins in regard to their roles in regulating proteases involved in inflammation, coagulation, and complement activation, particularly in the context of atherosclerosis. The overall goal of this review is to discuss potential functional roles of HDL in protease regulatory pathways based on current literature and known functions of HDL binding proteins and to promote the consideration of HDL as a global modulator of proteolytic equilibrium.

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Up regulation of C3, C4, and soluble intercellular adhesion molecule-1 co-expresses with high sensitivity C reactive protein in familial hypoalphalipoproteinaemia: further evidence of inflammatory activation

Cited by 9 publications

References 21 publications

Complement System and Rheumatoid Arthritis: Relationships with Autoantibodies, Serological, Clinical Features, and Anti-TNF Treatment

Complement System and Rheumatoid Arthritis: Relationships with Autoantibodies, Serological, Clinical Features, and Anti-TNF Treatment

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis

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