Untersuchungen über die Wirkung der Vitamin-A-Säure

Treatment of Photoaged Skin with Topical Tretinoin

“…He reasoned that a metabolite, perhaps retinoic acid, formed by oxidation of retinol might be the active agent. This was an inspired guess and led to a second paper which showed efficacy in such diverse prolif erative states as actinic keratoses, viral verrucae, ichthyosis, and basal cell carcinomas [2], Beer [3] confirmed these results, but topical tretinoin failed to gain widespread acceptance mainly because the high concentration, 0.3% was too irritating.…”

Behandlung des Lichen ruber mucosae mit Vitamin-A-Säure-Derivaten

“…18 Patienten waren männlich, 9 weiblich, der jüngste war 32, der älteste 75 Jahre alt, bei ei- Dermatosen, die mit Verhornungsanomalien einhergehen: verschiedene Formen der Ichthyosis, Pityriasis rubra pilaris, Morbus Darier, aktinische Keratosen, Keratosis palmaris et plantaris und Acne vulgaris [2], Der Wirkungsmechanismus der Vitamin-A-Säure auf die verhornende Epidermis ist dabei allerdings noch nicht restlos geklärt. Es konnte gezeigt werden, dass die Vitamin-A-Säure zu einer Steigerung der epidermalen Proli feration, Hemmung der Tonofilament-und Keratohyalinbildung und zur Störung der normalen Zellreifung führt [13].…”

Acne Pathogenesis: History of Concepts

“…He reported the keratolytic action and irritation occurring after few days [311]. The same year, Beer [312] published a study in which systemic and topical treatment were given to 53 patients, 20 of them suffering from acne. The acne patients did not respond [312].…”

“…The same year, Beer [312] published a study in which systemic and topical treatment were given to 53 patients, 20 of them suffering from acne. The acne patients did not respond [312]. ‘In 1963, at a staff conference at the University of Pennsylvania, Kligman observed that the skin of a patient treated for ichthyosis had turned red and was peeling.…”