Treatment of Photoaged Skin with Topical Tretinoin

Kligman, Albert M.; Leyden, James J.

doi:10.1159/000211167

Cited by 34 publications

(17 citation statements)

References 12 publications

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“…Studies of the effect of tretinoin treatment on the dermis of hairless mice [27,28] have found evidence for angiogenesis, while con flicting evidence has been reported in studies involving human subjects with photodamaged skin [10,20,[29][30][31]. The transient in crease in HbCb concentration with tretinoin treatment documented in this study does not support a claim for angiogenesis.…”

Section: Discussioncontrasting

confidence: 65%

Oxyhemoglobin Is a Quantifiable Measure of Experimentally Induced Chronic Tretinoin Inflammation and Accommodation in Photodamaged Skin

Kollias

Gillies²,

Muccini³

et al. 1997

Skin Pharmacol Physiol

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Chronic exposure to a weak irritant leads to inflammatory changes which may be followed by pigmentary changes and accommodation. The inflammatory responses to acute exposure to an irritant have been extensively studied. This study investigated quantitatively the inflammatory reactions produced in photodamaged skin with chronic application of a weak chemical irritant (tretinoin cream 0.025%) over a period of 9 months (36 weeks). Forty-eight subjects with moderately to severely photodamaged skin were enrolled in a 36-week, double-blind placebo-controlled study. Tretinoin cream was applied nightly on the distal two thirds of one dorsal forearm and placebo on the other. The proximal third of each dorsal forearm received no treatment and served as control. Clinical assessments and diffuse reflectance measurements were made at 7 time points during treatment. Apparent concentrations of oxyhemoglobin (HbO₂), deoxyhemoglo-bin (Hb) and melanin were estimated by analysis of the diffuse reflectance spectra. No changes were observed in the apparent H bO₂or the Hb concentration of the placebo-treated or control sites, thus establishing a reliable baseline. The apparent HbO₂ concentration of the tretinoin-treated sites increased significantly from baseline to a maximum at 12-18 weeks of treatment, then returned to baseline with continued applications. The changes in HbO₂ concentration agreed closely with clinical assessments of erythema. The apparent melanin concentration, corresponding to diffuse hyperpigmentation, showed a large seasonal decrease in both the control and the treated sites, with an additional decrease in the treated sites between 12 and 18 weeks. Erythema appeared after repeated applications and eventually resolved under continuous treatment. The maximum decrease in hyperpigmentation occurred simultaneously with the maximum increase in erythema.

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Section: Discussioncontrasting

confidence: 65%

Oxyhemoglobin Is a Quantifiable Measure of Experimentally Induced Chronic Tretinoin Inflammation and Accommodation in Photodamaged Skin

Kollias

Gillies²,

Muccini³

et al. 1997

Skin Pharmacol Physiol

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“…Thus, in histologic studies, following the topical application of 0.05% tretinoin, one can observe hyperplasia of the epidermis with elimination of dysplasia and atypia, melanosome dispersion, and the induction of dermal collagen formation 30,36 . The use of relatively high concentrations of GA, citric acid, or lactic acid (25%) over 6 months (twice daily application) can also induce hyperplasia, with decreased atypia, improved dispersion of melanosomes, and thicker elastin fibers 14 .…”

Section: Biologic Propertiesmentioning

confidence: 99%

The use of hydroxy acids on the skin: characteristics of C₈‐lipohydroxy acid

Saint‐Léger¹,

Lévêque

Verschoore

2007

J of Cosmetic Dermatology

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The hydroxy acids are widely used in skin creams because of their exfoliating and rejuvenating effect on photoaged skin. As a member of this family, the salicylic acid derivative known in the literature as 2-hydroxy-5-octanoyl benzoic acid or beta-lipohydroxy acid has also been proposed as an exfoliant and as a treatment of photoaged skin and acne. This article reviews the effects of the hydroxy acids and compares them to those of the salicylic acid derivative. We propose the name C(8)-lipohydroxy acid (C8-LHA) for this derivative to differentiate it from other related compounds. The lipophilic nature of C8-LHA and its relatively slow penetration in the skin afford it an exfoliating effect that is efficient at low concentrations. It appears to have antimicrobial, anti-inflammatory, and anticomedogenic properties, which make it effective against acne. Its antifungal and exfoliating properties are also likely to prove useful in combating dandruff.

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“…114,115 Topical retinoids represent one medical therapy capable of reorganizing dermal collagen and blood vessels, while also providing an anti-inflammatory effect. 42,43,46,[116][117][118][119][120] While it is clear that studies are required to establish the efficacy of this approach for rosacea, one author (M.T.P.) has been utilizing a topical retinoid approach adjunctively for rosacea for 5 years.…”

Section: Prevention and Repairmentioning

confidence: 99%