Behandlung des Lichen ruber mucosae mit Vitamin-A-Säure-Derivaten

Scheiber, W.; Plewig, Gerd

doi:10.1159/000250825

Cited by 29 publications

(3 citation statements)

References 8 publications

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“…Since some synthetic derivatives of retinoids were introduced (1), systemic administration of retinoids has been used extensively for a variety of skin disorders of keratinization with hyperkeratotic conditions. which respond promptly and regularly to oral administration of the drugs (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Retinoid Stimulates Epidermal Outgrowth of Pig Skin Explants

Aoyagi

Kamigaki

Kato

et al. 1981

The Journal of Dermatology

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Using a pig explant culture system, the effects of retinoids on pig epidermal cells were studied. Ro 10‐9359 slightly stimulated epidermal outgrowth, but this effect was not significant. Ro 10‐1670 (a metabolite of Ro 10‐9359) significantly stimulated epidermal outgrowth. Cytochalasin B and colchicine markedly inhibited the stimulatory effect of Ro 10‐1670, but hydroxyurea or cycloheximide did not completely block this stimulatory effect. During a migratory period, cytochalasin B completely blocked it. Neither Ro 10‐1670 nor Ro 10‐9359 effected a change in mitotic index. Histological studies revealed that Ro 10‐1670‐treated epidermal cells did not form any keratin layers. These results suggest that Ro 10‐1670 stimulated outgrowth, particularly migratory outgrowth, of epidermal cells, resulting in reduced keratin formation.

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Section: Introductionmentioning

confidence: 99%

Retinoid Stimulates Epidermal Outgrowth of Pig Skin Explants

Aoyagi

Kamigaki

Kato

et al. 1981

The Journal of Dermatology

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“…Many modes of treatment, including corticosteroids, have been tried with varying success (Samman 1979). Recently there have been several promising clinical reports on the use of Etreti-nate® (Ro 10-9359) (Cordero et al 1981, Maidhof 1979, Scheiber & Plewig 1978, Schuppli 1978. We found from a controlled study, that a dose of about 1 mg/kg/day gave a marked improvement in almost all patients (Hersle et al 1982).…”

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confidence: 85%

Severe oral lichen planus: remission and maintenance with Vitamin A analogues

Sloberg

Hersle

Mobacken

et al. 1983

J Oral Pathology Medicine

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Twenty-five patients with chronic oral lichen planus, usually of the atrophic-erosive type, were treated for 2 months with Etretinate® 0.6 mg/kg b.w./day, followed for 4 months by Etretinate® 0.3 mg/kg/day, or 0.1% Tretinoin® in an adhesive base. Complete resolution or improvement was seen in 85% of the lesions after first treatment. The number of patients with oral soreness and pain was significantly reduced (p< 0.001). During the second treatment, the improvement was maintained or even increased in about 70% of the patients, irrespective of the mode of treatment. Treatment was discontinued in one patient owing to moderately increased serum transaminase levels. The number of drug-related drop-outs was significantly lower than in a previous study utilizing an etretinate dose of about 1 mg/kg/day (p < 0.05). Other adverse effects were minor and tolerable. Retinoids offer an effective mode of therapy for severe oral lichen planus.

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“…(I. 7,11). Due to the improved clinical course, a nor malization of the disturbed proliferation and kera tinization has been attributed to this therapy in l.p.rn.…”

Section: Abbreviations 11sedmentioning

confidence: 99%

Epithelial cell proliferation of oral lichen planus in patients treated with an aromatic retinoid

Schell,

Hornstein,

Deinlein

et al. 1983

Acta Derm Venereol

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In 4 patients with lichen planus mucosae (l.p.m.) biopsies were taken from the involved and uninvolved buccal sides before treatment and from the affected side after a 3-week systemic therapy with aromatic retinoid (Ro 10-9359; 50 mg/die). After in vitro labelling with 3H-thymidine the epithelial cell proliferation was determined histo-autoradiographically. In atrophic lesions of l.p.m., increased 3H-thymidine labelling indices were observed during retinoid therapy. After 3 weeks of treatment the augmented relative portion of labelled basal cells (quotient LIbas/LIsuprabas) was found to be lowered, indicating a tendency of proliferating cells to regain normal distribution in the progenitor compartment of the mucosa epithelium.

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Behandlung des Lichen ruber mucosae mit Vitamin-A-Säure-Derivaten

Cited by 29 publications

References 8 publications

Retinoid Stimulates Epidermal Outgrowth of Pig Skin Explants

Retinoid Stimulates Epidermal Outgrowth of Pig Skin Explants

Severe oral lichen planus: remission and maintenance with Vitamin A analogues

Epithelial cell proliferation of oral lichen planus in patients treated with an aromatic retinoid

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