Untersuchungen über den klinischen Einsatz von Brushite- und Hydroxylapatit-Zement beim Schaf

Oberle, Andrea; Theiss, Felix; Bohner, Marc; Müller, Jacqueline; Kästner, S.; Frei, C.; Boecken, Ilka; Zlinszky, K.; Wunderlin, Sabina; Auer, Jörg A; Rechenberg, Brigitte von

doi:10.1024/0036-7281.147.11.482

Cited by 26 publications

(8 citation statements)

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“…No macroscopic signs of inflammatory reactions were generally seen even at the early time points. However, this was dependent on the implanted material [ 44 ]. Normally, the radiographs taken with the faxitron machine revealed the location and direction of the drill hole, although at later time points (24 weeks) depending on the biomaterials bone healing could be so far advanced that detection proved to be difficult and only signs of intensive bone remodelling indicated the original bone defects.…”

Section: Resultsmentioning

confidence: 99%

An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones

Nuss

Auer

Boos³

et al. 2006

BMC Musculoskelet Disord

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BackgroundThe past years have seen the development of many synthetic bone replacements. To test their biocompatibility and ability for osseointegration, osseoinduction and -conduction requires their placement within bone preferably in an animal experiment of a higher species.MethodsA suitable experimental animal model in sheep with drill holes of 8 mm diameter and 13 mm depth within the proximal and distal humerus and femur for testing biocompatibility issues is introduced.ResultsThis present sheep model allows the placing of up to 8 different test materials within one animal and because of the standardization of the bone defect, routine evaluation by means of histomorphometry is easily conducted. This method was used successfully in 66 White Alpine Sheep. When the drill holes were correctly placed no complications such as spontaneous fractures were encountered.ConclusionThis experimental animal model serves an excellent basis for testing the biocompatibility of novel biomaterials to be used as bone replacement or new bone formation enhancing materials.

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Section: Resultsmentioning

confidence: 99%

An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones

Nuss

Auer

Boos³

et al. 2006

BMC Musculoskelet Disord

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“…It is known for serum proteins to be adsorbed onto the cement surface, altering the interfacial properties of the calcium phosphate crystals [397], and favoring in vivo resorption [391]. Research shows that unlike HA cements that undergo negligible resorption over time, dicalcium phosphate cements resorb to a much greater extent in vivo [386,398]. Following implantation, they appear to be rapidly resorbed by simple dissolution and cellular activity [318,399], although the later seems to be the more predominant factor [400].…”

Section: Biodegradation Of Implanted Materials and Bone Tissue Formentioning

confidence: 99%

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

et al. 2015

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This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and regeneration applications require better control of interfacing between the material and the surrounding bone tissue. Also, the mechanical properties and degradation/resorption profiles of these materials require further improvement to broaden their use and achieve better clinical results.

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“…(•) Brushite cement . (□) Brushite and apatite cement (Oberle et al, 2005). (■) Brushite and apatite cement (Apelt et al, 2004); (◊) β-TCP and monetite (unpublished results).…”

Section: Designmentioning

confidence: 99%

Effect of grain size and microporosity on the in vivo behaviour of β-tricalcium phosphate scaffolds

Lapczyna

Galea²,

Wüst

et al. 2014

eCM

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Defining the most adequate architecture of a bone substitute scaffold is a topic that has received much attention over the last 40 years. However, contradictory results exist on the effect of grain size and microporosity. Therefore, the aim of this study was to determine the effect of these two factors on the in vivo behaviour of β-tricalcium phosphate (β-TCP) scaffolds. For that purpose, β-TCP scaffolds were produced with roughly the same macropore size (≈ 150 μm), and porosity (≈ 80 %), but two levels of microporosity (low: 10 % / high: ≈ 25 %) and grain size (small: 1.3 μm /large: ≈ 3.3 μm). The sample architecture was characterised extensively using materialography, Hg porosimetry, micro-computed tomography (μCT), and nitrogen adsorption. The scaffolds were implanted for 2, 4 and 8 weeks in a cylindrical 5-wall cancellous bone defect in sheep. The histological, histomorphometrical and μCT analysis of the samples revealed that all four scaffold types were almost completely resorbed within 8 weeks and replaced by new bone. Despite the three-fold difference in microporosity and grain size, very few biological differences were observed. The only significant effect at p < 0.01 was a slightly faster resorption rate and soft tissue formation between 4 and 8 weeks of implantation when microporosity was increased. Past and present results suggest that the biological response of this particular defect is not very sensitive towards physico-chemical differences of resorbable bone graft substitutes. As bone formed not only in the macropores but also in the micropores, a closer study at the microscopic and localised effects is necessary.

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Untersuchungen über den klinischen Einsatz von Brushite- und Hydroxylapatit-Zement beim Schaf

Cited by 26 publications

References 0 publications

An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones

An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

Effect of grain size and microporosity on the in vivo behaviour of β-tricalcium phosphate scaffolds

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