Untersuchungen an 1,3‐Dicarbonyl‐Verbindungen, 22. Mitt. 3‐Acyl‐4‐oxo‐4H‐[1]benzofuro[3,2‐b]pyrane

Abstract

Es wird über Versuche berichtet, den Aldehyd 7 als Schlüsselverbindung zur Darstellung von möglicherweise antiallergisch aktiven Substanzen zu erhalten.

Synthesis of 4H-chromene, coumarin, 12H-chromeno[2,3-d]pyrimidine derivatives and some of their antimicrobial and cytotoxicity activities

“…Structures of 10 and 11 were established on the basis of IR, 1 H NMR, 13 Treatment of 10a with NH 3 gas in methanol at room temperature for 1h yielded the open chain product (E) N 0 -(4-(4-chlorophenyl)-3-cyano-7-(diethylamino)-4H-chromen-2-yl)formimidamide (15A) which is in equilibrium with its tautomer N-(4-(4-chlorophenyl)-3-cyano-7-(diethylamino)-4H-chromen-2-yl)formimidamide (15B) (Scheme 6). Similar ammonolysis of 10a for 2 h afforded the cyclic addition product 4-amino-5-(4-chlorophenyl)-8-(diethylamino)-5H-chromeno[2, 3-d]pyrimidine (16). Structure of 16 was supported by its independent synthesis from 3a and formamide [26,29] and also by cyclization of 15 in dioxan and piperdine under reflux [31] …”

“…Fused chromene ring systems have platelet antiaggregating, local anesthetic [13e15] and antihistaminic activities [16]. They also exhibit antidepressant effects [17], inhibitory effect on influenza virus sialidases [18,19], DNA breaking activities and mutagenicity [20], antiviral activities [21] and act as sex pheromone homologes [22].…”

2-Amino-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 1,4-dioxane hemisolvate

“…For the biological activity of pyran and fused-pyran molecules, see: Bargagna et al (1992); Symeonidis et al (2009); Narender & Gupta (2009); Alvey et al (2009); Gorlitzer et al (1984); Han et al (2008); Martinez & Marco (1997); Smith et al (1998); Taylor et al (1998). For related structures, see: Gourdeau et al (2004); Foroumadi et al (2007); Mohamed et al (2012).…”

“…Pyran and fused pyran ring systems are biologically interesting compounds known for their antimicrobial and antifungal (Alvey, et al, 2009), antioxidant (Symeonidis et al, 2009), antileishmanial (Narender et al, 2009), antitumor (Han et al, 2008). In addition, fused chromene ring systems have platelet antiaggregating, local anesthetic (Bargagna et al 1992) and antihistaminic activities (Gorlitzer et al 1984). They also exhibit inhibitory effects on influenza virus sialidases Taylor et al 1998) and antiviral activities (Martinez & Marco, 1997).…”

Design, synthesis, characterization, antioxidant and in vitro cytotoxic activities of novel coumarin thiazole derivatives

“…Coumarin and its derivatives are biologically interesting compounds known for their antimicrobial and antifungal (Zamocka et al, 1992), antileishmanial (Narender and Gupta, 2009), antioxidant (Alvey et al, 2008;Christos and Dimitra, 2004;Zhang et al, 2011), Cytotoxic (Nermien et al, 2011;Afsheen et al, 2011;Mahantesha et al, 2014) antitumour (Mohr et al, 1975), antiproliferation (Brunavs et al, 1993), hypotensive (Tandon et al, 1991), antiallergic (Narender et al, 1983;Coudert et al, 1988), Local anaesthetic ), central nervous system (CNS) activities and effects (Eiden and Denk, 1991), as well as treatment of Alzheimer's disease (Bruhlmann et al, 2001) and Schizophrenia disorder (Kesten et al, 1999). Fused chromene ring systems have platelet anti-aggregating, local anaesthetic (Bargagna et al, , 1991(Bargagna et al, , 1992 and antihistaminic activities (Gorlitzer et al, 1984). They also exhibit antidepressant effects (Ermili et al, 1979), inhibitory effect on influenza virus sialidases Taylor et al, 1998), DNA breaking activities and mutagenicity (Hiramoto et al, 1997), and antiviral activities (Martinez and Marco, 1997), and act as sex pheromonehomologes (Bianchi and Tava, 1987).…”