“…Examples of these parasite's moonlighting enzymes include: a hexokinase in Leishmania donovani , which functions as a hemoglobin receptor within the parasite's flagellar pocket; the glycolytic enzyme aldolase in Toxoplasma gondii and Plasmodium falciparum , which has an additional (even if non-essential) function in host-cell invasion; various soluble metabolic enzymes in Trichomonas vaginalis , which moonlight as adhesins allowing parasite-host cell adhesion; the mitochondrial peroxiredoxin in Leishmania infantum , which not only functions as a peroxidase, but also as a chaperone essential for pathogenesis; the α-ketoglutarate dehydrogenase E2 in bloodstream Trypanosoma brucei , which moonlights in the mitochondria ensuring a correct kinetoplast DNA inheritance (Collingridge et al, 2010; Ginger, 2014). Recently, Ferreira and colleagues have shown that the enzyme mevalonate kinase, originally involved in sterol isoprenoids biosynthesis in T. cruzi 's glycosomes, is also secreted and may modulate host cell signaling during parasite invasion (Ferreira et al, 2016). …”