“…In last two decades, nanoparticles gained attention in many fields such as semiconductor, biomedical, chemical, and environmental ( 16 – 19 ) Nanoparticles with size below 100 nm shows unique properties due to dominance of quantum effect and highly increase of surface area, which makes them suitable for novel applications such as electronics, communication, energy, defense and biomedical including drug delivery ( 16 , 20 , 21 ). According to Ostwald-Freundlich equation due to enormous surface area increases saturation solubility and increases dissolution kinetics according to Noyes-Whitney equation ( 22 , 23 ).…”