Nanotechnology-Assisted Metered-Dose Inhalers (MDIs) for High-Performance Pulmonary Drug Delivery Applications

Kumar, Raj; Mehta, Piyush; Shankar, K. Ravi; Rajora, Manju A K; Mishra, Yogendra Kumar; Mostafavi, Ebrahim; Kaushik, Ajeet

doi:10.1007/s11095-022-03286-y

Cited by 32 publications

(14 citation statements)

References 142 publications

(123 reference statements)

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“…This result could be attributed to the lower size of M2 droplets than M1, which ensured a larger surface area for a more effective drug delivery [ 39 ]. However, in all of the cases, the prolonged release could be favorable for achieving suitable local drug concentrations over time and obtaining a more prolonged effect, thus minimizing the dosing and improving the effectiveness of skin infection treatment [ 53 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of Azithromycin-Loaded Microemulsions: A Promising Tool for the Treatment of Bacterial Skin Infections

et al. 2022

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In recent years, the treatment of bacterial skin infections has been considered a major healthcare issue due to the growing emergence of antibiotic-resistant strains of Staphylococcus aureus. The incorporation of antibiotics in appropriate nanosystems could represent a promising strategy, able to overcome several drawbacks of the topical treatment of infections, including poor drug retention within the skin. The present work aims to develop microemulsions containing azithromycin (AZT), a broad-spectrum macrolide antibiotic. Firstly, AZT solubility in various oils, surfactants and co-surfactants was assessed to select the main components. Subsequently, microemulsions composed of vitamin E acetate, Labrasol® and Transcutol® P were prepared and characterized for their pH, viscosity, droplet size, zeta potential and ability to release the drug and to promote its retention inside porcine skin. Antimicrobial activity against S. aureus methicillin-resistant strains (MRSA) and the biocompatibility of microemulsions were evaluated. Microemulsions showed an acceptable pH and were characterized by different droplet sizes and viscosities depending on their composition. Interestingly, they provided a prolonged release of AZT and promoted its accumulation inside the skin. Finally, microemulsions retained AZT efficacy on MRSA and were not cytotoxic. Hence, the developed AZT-loaded microemulsions could be considered as useful nanocarriers for the treatment of antibiotic-resistant infections of the skin.

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Section: Resultsmentioning

confidence: 99%

Development and Characterization of Azithromycin-Loaded Microemulsions: A Promising Tool for the Treatment of Bacterial Skin Infections

et al. 2022

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“…Although engineering ferroptosis inhibitors as inhalable nanomedicines for th highly efficient treatment of IPF is promising, there are some concerns about the safety o MDIs mean that the drug and the propellants (e.g., HFA 134a) are enclosed together in a pressurized container with a dosing valve, and are sprayed out by means of an external force, which have the advantage of being stable, cheap, and simple to install [53]. However, MDIs require a high level of patient cooperation (inhalation while the drug is being injected) yet at least 50% of patients are poorly cooperative, making drug delivery inefficient.…”

Section: Discussionmentioning

confidence: 99%

Engineering Ferroptosis Inhibitors as Inhalable Nanomedicines for the Highly Efficient Treatment of Idiopathic Pulmonary Fibrosis

Guo

Peng

et al. 2023

Bioengineering

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Idiopathic pulmonary fibrosis (IPF) refers to chronic progressive fibrotic interstitial pneumonia. It is called a “tumor-like disease” and cannot be cured using existing clinical drugs. Therefore, new treatment options are urgently needed. Studies have proven that ferroptosis is closely related to the development of IPF, and ferroptosis inhibitors can slow down the occurrence of IPF by chelating iron or reducing lipid peroxidation. For example, the ferroptosis inhibitor deferoxamine (DFO) was used to treat a mouse model of pulmonary fibrosis, and DFO successfully reversed the IPF phenotype and increased the survival rate of mice from 50% to 90%. Given this, we perceive that the treatment of IPF by delivering ferroptosis inhibitors is a promising option. However, the delivery of ferroptosis inhibitors faces two bottlenecks: low solubility and targeting. For one thing, we consider preparing ferroptosis inhibitors into nanomedicines to improve solubility. For another thing, we propose to deliver nanomedicines through pulmonary drug-delivery system (PDDS) to improve targeting. Compared with oral or injection administration, PDDS can achieve better delivery and accumulation in the lung, while reducing the systemic exposure of the drug, and is an efficient and safe drug-delivery method. In this paper, three possible nanomedicines for PDDS and the preparation methods thereof are proposed to deliver ferroptosis inhibitors for the treatment of IPF. Proper administration devices and challenges in future applications are also discussed. In general, this perspective proposes a promising strategy for the treatment of IPF based on inhalable nanomedicines carrying ferroptosis inhibitors, which can inspire new ideas in the field of drug development and therapy of IPF.

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“…The easy induction of an immune response mediated via antigen-presenting cells using gold nanoparticles makes them a desirable candidate for use in the creation of vaccines. The ability to be easily modified for distribution through the nasal cavity is a benefit of using gold nanoparticles [ 100 ]. By spreading to the lymph nodes, they also have the benefit of triggering the immunological response linked to CD8+ (cytotoxic) T cells [ 100 ].…”

Section: Application Of Nanotechnology In Covid-19 Therapeuticsmentioning

confidence: 99%

“…The ability to be easily modified for distribution through the nasal cavity is a benefit of using gold nanoparticles [ 100 ]. By spreading to the lymph nodes, they also have the benefit of triggering the immunological response linked to CD8+ (cytotoxic) T cells [ 100 ].…”

Section: Application Of Nanotechnology In Covid-19 Therapeuticsmentioning

confidence: 99%

Aspects of Nanotechnology for COVID-19 Vaccine Development and Its Delivery Applications

et al. 2023

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Coronavirus, a causative agent of the common cold to a much more complicated disease such as “severe acute respiratory syndrome (SARS-CoV-2), Middle East Respiratory Syndrome (MERS-CoV-2), and Coronavirus Disease 2019 (COVID-19)”, is a member of the coronaviridae family and contains a positive-sense single-stranded RNA of 26–32 kilobase pairs. COVID-19 has shown very high mortality and morbidity and imparted a significantly impacted socioeconomic status. There are many variants of SARS-CoV-2 that have originated from the mutation of the genetic material of the original coronavirus. This has raised the demand for efficient treatment/therapy to manage newly emerged SARS-CoV-2 infections successfully. However, different types of vaccines have been developed and administered to patients but need more attention because COVID-19 is not under complete control. In this article, currently developed nanotechnology-based vaccines are explored, such as inactivated virus vaccines, mRNA-based vaccines, DNA-based vaccines, S-protein-based vaccines, virus-vectored vaccines, etc. One of the important aspects of vaccines is their administration inside the host body wherein nanotechnology can play a very crucial role. Currently, more than 26 nanotechnology-based COVID-19 vaccine candidates are in various phases of clinical trials. Nanotechnology is one of the growing fields in drug discovery and drug delivery that can also be used for the tackling of coronavirus. Nanotechnology can be used in various ways to design and develop tools and strategies for detection, diagnosis, and therapeutic and vaccine development to protect against COVID-19. The design of instruments for speedy, precise, and sensitive diagnosis, the fabrication of potent sanitizers, the delivery of extracellular antigenic components or mRNA-based vaccines into human tissues, and the administration of antiretroviral medicines into the organism are nanotechnology-based strategies for COVID-19 management. Herein, we discuss the application of nanotechnology in COVID-19 vaccine development and the challenges and opportunities in this approach.

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Nanotechnology-Assisted Metered-Dose Inhalers (MDIs) for High-Performance Pulmonary Drug Delivery Applications

Cited by 32 publications

References 142 publications

Development and Characterization of Azithromycin-Loaded Microemulsions: A Promising Tool for the Treatment of Bacterial Skin Infections

Development and Characterization of Azithromycin-Loaded Microemulsions: A Promising Tool for the Treatment of Bacterial Skin Infections

Engineering Ferroptosis Inhibitors as Inhalable Nanomedicines for the Highly Efficient Treatment of Idiopathic Pulmonary Fibrosis

Aspects of Nanotechnology for COVID-19 Vaccine Development and Its Delivery Applications

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