Unfavorable lipid profile in women with endometriosis

Melo, Anderson Sanches de; Silva, Júlio César Rosa e; Rosa‐e‐Silva, Ana Carolina Japur de Sá; Neto, Omero Benedicto Poli; Ferriani, Rui Alberto; Vieira, Carolina Sales

doi:10.1016/j.fertnstert.2009.08.043

Cited by 84 publications

(69 citation statements)

References 30 publications

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“…This association was also consistent with earlier case-control studies discussed above, [9][10][11] which found that women with endometriosis had higher level of LDL compared with women without endometriosis. Because the previous studies were cross-sectional, it was unknown whether higher LDL could increase the risk of endometriosis or the presence of endometriosis could result in higher level of LDL.…”

Section: Analysis 2: Hypercholesterolemia or Hypertension In Relationsupporting

confidence: 92%

“…36,37 In addition, the association observed between endometriosis and hypercholesterolemia was consistent with earlier casecontrol studies. [9][10][11] The largest sample size among these studies, however, was 40 cases and 80 controls.…”

Section: Analysis 2: Hypercholesterolemia or Hypertension In Relationmentioning

confidence: 99%

“…[5][6][7][8] Several case-control studies have found that women with endometriosis had higher serum levels of low-density lipoprotein (LDL) or oxidized LDL compared with controls. [9][10][11] It is possible that chronic inflammation, such as that associated with endometriosis, could impact lipid metabolism through various mechanisms and lead to high LDL levels 12,13 -the primary form of hypercholesterolemia.…”

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confidence: 99%

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Association Between Endometriosis and Hypercholesterolemia or Hypertension

Rich‐Edwards

Rimm

et al. 2017

Hypertension

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Abstract-An altered hormonal or chronic systemic inflammatory milieu characterizing endometriosis may result in a higher risk of hypercholesterolemia and hypertension. Conversely, elevated low-density lipoprotein in hypercholesterolemia and chronic systemic inflammation resulting from hypertension may increase the risk of endometriosis. We assessed the association of laparoscopically confirmed endometriosis with hypercholesterolemia and hypertension in a large prospective cohort study. In 1989, 116 430 registered female nurses aged 25 to 42 completed the baseline questionnaire and were followed for 20 years. Multivariable Cox proportional hazards models were applied. In 1989, there were 4244 women with laparoscopically confirmed endometriosis and 91 554 women without. After adjusting for demographic, anthropometric, family history, reproductive, dietary, and lifestyle risk factors prospectively, comparing women with laparoscopically confirmed endometriosis to women without, the relative risks were 1.25 (95% confidence interval, 1.21-1.30) for development of hypercholesterolemia and 1.14 (95% confidence interval, 1.09-1.18) for hypertension. Conversely, the relative risks of developing laparoscopically confirmed endometriosis were 1.22 (95% confidence interval, 1.15-1.31) comparing women with hypercholesterolemia to women without and 1.29 (95% confidence interval, 1.18-1.41) comparing women with hypertension to women without. The strength of associations of laparoscopically confirmed endometriosis with hypercholesterolemia or hypertension was strongest among women aged ≤40 and weakened as age increased (P values for interaction <0.001). We observed that ≈45% of the associations between endometriosis and hypercholesterolemia and hypertension could be accounted for by treatment factors after endometriosis diagnosis, including greater frequency of hysterectomy/oophorectomy and earlier age for this surgery. In this large cohort study, laparoscopically confirmed endometriosis was prospectively associated with increased risk of hypercholesterolemia and hypertension. Conversely, hypercholesterolemia and hypertension were prospectively associated with higher risk of laparoscopically confirmed endometriosis. process, which may be contributing to blood pressure elevation. 23 Hence the chronic systemic inflammation in endometriosis may predispose women with endometriosis to a higher risk of hypertension.In sum, women with endometriosis may have higher risk of hypercholesterolemia or hypertension, and women with hypertension or hypercholesterolemia may have a higher risk of endometriosis. We examined these hypotheses in the NHSII (Nurses' Health Study II), an ongoing prospective cohort study. Methods Study PopulationThe NHSII is a prospective cohort study with 116 430 registered female nurses who were 25 to 42 and resided in 14 of the United States at enrollment in 1989. At baseline, participants completed a detailed questionnaire and every 2 years thereafter completed follow-up questionnaires on the incidence of disease out...

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Section: Analysis 2: Hypercholesterolemia or Hypertension In Relationsupporting

confidence: 92%

Section: Analysis 2: Hypercholesterolemia or Hypertension In Relationmentioning

confidence: 99%

mentioning

confidence: 99%

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Association Between Endometriosis and Hypercholesterolemia or Hypertension

Rich‐Edwards

Rimm

et al. 2017

Hypertension

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“…В то время как нормальный эндометрий не продуцирует E 2 , стромальные клетки эндометриоидных гетеро-топий экспрессируют полный ферментативный каскад, необходимый для синтеза Е 2 из холе-стерина [29]. Несмотря на то что проведенный в 2017 году метаанализ показал отрицательную корреляцию между ИМТ и риском развития эндометриоза [30], липидный профиль в груп-пе больных эндометриозом характеризуется негативными изменениями [31,32]. Согласно полученным данным уровень общего холесте-рина выше на 20 %, а уровень липопротеидов низкой плотности -на 30 % по сравнению с аналогичными показателями в контрольной группе [33].…”

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Prospects of metformin in the treatment of endometriosis

2017

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According to recent year studies, the classical biguanide metformin has antiproliferative, proapoptotic and anti-inflammatory effects in addition to the main hypoglycemic effect. There are clinical and experimental studies these effects in the therapy of oncological and benign hyperplastic diseases. There is no data about the clinical efficacy of metformin in the therapy of endometriosis in the domestic literature, and there were a few studies in foreign sources. There was a decrease in the severity of the pain syndrome and an increase of pregnancy rate in two clinical studies with small samples. However, future studies are needed to investigate the mechanisms of the target drug effect and to develop effective regimens for the treatment of endometriosis.

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“…[8] In contrast, Melo et al report that patients affected by endometriosis frequently show "unfavourable" lipid profile (increase in low-density and reduction in high-density lipoprotein), potentially favouring the oxidative stress (via lipid peroxidation) typically increased in this cohort of women. [9][10][11] D-chiro inositol is a "dietary supplement" of Inositol, an essential component of the phospholipids that make up cellular membranes, detectable in every cell of the body. The available formulations for oral administration show good bioavailability, safe pharmacologic profiles and beneficial effects in improving spontaneous fertility (or success rate of ARTs) also after short-term treatment, particularly in patients affected by PCOS and anovulation.…”

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confidence: 99%