Unexplained chronic cough and vitamin B-12 deficiency

Abstract

This study suggests that Cbl-D may contribute to chronic cough by favoring sensory neuropathy as indicated by laryngeal hyperresponsiveness and increased NGF expression in pharyngeal biopsies of Cbl-D patients. Cbl-D should be considered among factors that sustain chronic cough, particularly when cough triggers cannot be identified.

Relationships between cobalamin, epidermal growth factor, and normal prions in the myelin maintenance of central nervous system

“…On the contrary, Cbl up-regulates: (i) EGF levels in rat SC (by increasing its synthesis in neurons and glia) and CSF, and in human serum and CSF; and (ii) interleukin (IL)-6 levels in rat CSF Scalabrino, 2009). Most of the above findings have been confirmed by others (Battaglia-Hsu et al, 2009;Bucca et al, 2011;Ç eneli et al, 2010;Sampaio et al, 2013). The specificity of the cytokine and/or growth factor abnormalities induced by Cbl deficiency is demonstrated by their normalization after the Cbl replacement therapy in rats and patients with pernicious anemia, and the fact that the CSF levels of some neuropeptides and neurohormones Cbl as a fulcrum between physiologically myelinotrophic (green) and potential myelinodamaging agents (red) in rat CNS.…”

Effect of iron supplementation in women with chronic cough and iron deficiency

“…Moreover, iron is required for proper myelination of the spinal cord (36). We recently found that deficiency of vitamin B‐12, a nutrient involved in myelin synthesis, may cause cough and laryngeal hyperresponsiveness through sensory neuropathy (37).…”

Chronic cough: clinical characteristics and etiologies of 510 cases

“…Cough-variant asthma (CVA) or nonasthmatic eosinophilic bronchitis (EB) (8) are other possible etiologies; iron and vitamin B-12 deficiencies are rare causes of CC (9,10).…”