Effect of iron supplementation in women with chronic cough and iron deficiency

Bucca, Caterina; Culla, Beatrice; Brussino, Luisa; Ricciardolo, Fabio Luigi Massimo; Cicolin, Alessandro; Heffler, Enrico; Bugiani, Massimiliano; Rolla, Giovanni

doi:10.1111/ijcp.12001

Cited by 29 publications

(18 citation statements)

References 33 publications

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“…Traumas, infections, stress, or medical procedures are potential triggers for HAE attacks, although they are not always so clearly detectable. Occasionally, angioedema could be associated with prodromal signs, including erythema marginatum 4–6…”

Section: Introductionmentioning

confidence: 99%

Breakthroughs in hereditary angioedema management: a systematic review of approved drugs and those under research

Nicola

Rolla

Brussino

2019

DIC

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Hereditary angioedema (HAE) is a rare genetic disorder, characterized by recurrent and unexpected potentially life-threatening mucosal swelling. The impairment underlying HAE could be a defect in C1-inhibitor activity, or in its serum concentration. Patients affected by HAE should be treated with on-demand or prophylactic drugs. Lifelong C1-inhibitor supplementation is sometimes required. In this review, we review the currently approved drugs for HAE due to C1-inhibitor defect and to describe those under research. In particular, we focused on the mechanisms of action, routes of administration, and efficacy of these therapies. A systematic review of the literature was performed using the PubMed database for original articles and clinical trials of HAE treatments from 2005 to 2019. The approved HAE treatments can minimize the risk of death, but they are not effective in complete healing from the disease. The new gene therapies seem to provide promising opportunities for the treatment of hereditary angioedema. However, there are still many unmet needs, including efficacy, route, and timing of administration.

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Section: Introductionmentioning

confidence: 99%

Breakthroughs in hereditary angioedema management: a systematic review of approved drugs and those under research

Nicola

Rolla

Brussino

2019

DIC

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“…However, some recent studies suggest that iron status may affect the lungs. In one study, iron supplementation in iron deficient women (average serum ferritin of 9.3 ng/ml at baseline, increased to an average of 42.9 ng/ml after supplementation) led to resolution of chronic cough and bronchial hyperreactivity [ 24 ]. Notably, forty-one percent of these women had normal hemoglobin levels at baseline prior to supplementation, implicating iron repletion as the primary factor in their symptom improvement.…”

Section: Discussionmentioning

confidence: 99%

Iron Status is Associated with Asthma and Lung Function in US Women

et al. 2015

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BackgroundAsthma and iron deficiency are common conditions. Whether iron status affects the risk of asthma is unclear.ObjectiveTo determine the relationship between iron status and asthma, lung function, and pulmonary inflammation.MethodsRelationships between measures of iron status (serum ferritin, serum soluble transferrin receptor (sTfR), and sTfR/log10ferritin (sTfR-F Index)) and asthma, lung function, and pulmonary inflammation were examined in women 20-49 years in the National Health and Nutrition Examination Survey. Logistic, linear, and quadratic regression models accounting for the survey design of NHANES were used to evaluate associations between iron status and asthma-related outcomes and were adjusted for race/ethnicity, age, smoking status, income, and BMI.ResultsApproximately 16% reported a lifetime history of asthma, 9% reported current asthma, and 5% reported a recent asthma episode/attack (n = 2906). Increased ferritin (iron stores) was associated with decreased odds of lifetime asthma, current asthma, and asthma attacks/episodes in the range of ferritin linearly correlated with iron stores (20-300ng/ml). The highest quintile of ferritin (>76 ng/ml) was also associated with a decreased odds of asthma. Ferritin levels were not associated with FEV1. Increased values of the sTfR-F Index and sTfR, indicating lower body iron and higher tissue iron need, respectively, were associated with decreased FEV1, but neither was associated with asthma. None of the iron indices were associated with FeNO.ConclusionIn US women, higher iron stores were inversely associated with asthma and lower body iron and higher tissue iron need were associated with lower lung function. Together, these findings suggest that iron status may play a role in asthma and lung function in US women.

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“…Cough-variant asthma (CVA) or nonasthmatic eosinophilic bronchitis (EB) (8) are other possible etiologies; iron and vitamin B-12 deficiencies are rare causes of CC (9,10).…”

Section: Introductionmentioning

confidence: 99%

Chronic cough: clinical characteristics and etiologies of 510 cases

Jiang

Huang

et al. 2016

Turk J Med Sci

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Background/aim: To investigate the clinical features and underlying etiologies of chronic cough (CC).Materials and methods: Five hundred and ten CC patients were enrolled. The phases, characteristics and associated clinical manifestations of CC among the gastroesophageal reflux cough (GERC), cough-variant asthma (CVA), and upper airway cough syndrome (UACS) groups were compared, and the diagnostic values of each group were evaluated by multiple regression analysis.Results: In the 510 patients, 404 had CC with single etiology-GERC (n = 175), CVA (n = 134), and UACS (n = 95). The characteristic features of GERC included gastric acid backflow symptoms such as sour-tasting regurgitation, heartburn, endoscopic esophagitis, poststimulation cough, frequent throat clearing, daytime mono-cough, and feelings of heaviness and pain in the chest. Patients with CVA typically exhibited sensitivity to smog and other irritants; the cough occurred mostly at night, and was associated with positive bronchodilator and provocation test results. The typical features of UACS included a history and/or symptoms of rhinitis, retropharyngeal postnasal drip, and wet cough occurring mostly during the daytime. The diagnostic specificities of above factors were >70%. Conclusion:The most common causes of CC include GERC, CVA, and UACS, and their diagnosis is based on the characteristics of the underlying disease.

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Effect of iron supplementation in women with chronic cough and iron deficiency

Abstract: In women with unexplained chronic cough unresponsive to targeted treatment, airway and cough hyperresponsiveness may be sustained by iron deficiency. Healthy women with chronic cough should be checked for iron deficiency as iron repletion may resolve such disturbing symptom.

Cited by 29 publications

References 33 publications

Breakthroughs in hereditary angioedema management: a systematic review of approved drugs and those under research

Breakthroughs in hereditary angioedema management: a systematic review of approved drugs and those under research

Iron Status is Associated with Asthma and Lung Function in US Women

Chronic cough: clinical characteristics and etiologies of 510 cases

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