Undifferentiated Tumors: An Immunohistochemical Analysis on Biopsies

Vege, D. S.; Soman, C. S.; Joshi, Ujjwala; Ganesh, B; Yadav, Jyoti

doi:10.1002/jso.2930570414

Cited by 13 publications

(19 citation statements)

References 21 publications

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“…From the 1192 malignant cases of head and neck malignant tumours investigated in this study, 142 (11.9%) were poorly differentiated/undifferentiated while the remaining 1050 (88.1%) were differentiated, giving a ratio of undifferentiated to differentiated tumours in this study as 1:7.4, which is higher than 1:9 computed from the study by Vege et al [43]. Relatively higher prevalence of poorly differentiated cancers in Africans has been reported [44].…”

Section: Discussioncontrasting

confidence: 55%

Clinico-pathological profile of head and neck malignancies at University College Hospital, Ibadan, Nigeria

et al. 2011

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IntroductionThis retrospective study analysed head and neck malignancies seen over a 19-year period at the University College Hospital, Ibadan.MethodologyOne thousand, one hundred and ninety two patients with head and neck malignancies were analysed according to age, gender, topography and histology.ResultsThere was an annual hospital frequency of 62 cases per year. The overall mean age for these malignancies was 43.9 (SD ± 19.3) years. The lesions from the respiratory tract were the most frequent (43.2%) of all cases. The palate was the most frequent intra-oral site (13.8%). Epithelial malignancies constituted 73.4% of all cases with a male: female ratio of 2:1, a mean age of 48.1 (SD ± 17.5) years and were mostly located in the larynx (19.7%). Lymphomas constituted 17.5% of all head and neck cancers with a male: female ratio of 1.6:1, a mean age of 35.1 (SD ± 20.6) years and nodal involvement (39.7%) was most common. Sarcomas constituted 8.9% of all malignancies with a male: female ratio of 1.5:1, mean age of 27.1 (SD ± 16.7) years and the maxillofacial bones (42.5%) were most commonly involved. Neuroendocrine malignancies accounted for 0.2% of head and neck malignancies with a male: female ratio of 1:1, a mean age of 28.5 (SD ± 6.4) years and both cases involved the nose.ConclusionThis study has further confirmed that carcinomas remain the most frequent cancers of the head and neck region in south-western Nigeria.

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Section: Discussioncontrasting

confidence: 55%

Clinico-pathological profile of head and neck malignancies at University College Hospital, Ibadan, Nigeria

et al. 2011

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“…The surgical pathology knowledge has revolutionized by applying immunohistochemical technique, because it is essential for the correct diagnosis of the neoplasia and for successful therapy, prognosis and outcome. 10 This cross-sectional study was carried out with an aim to know the role of immunohistochemistry to diagnose undifferentiated malignancy in head and neck region.…”

Section: Discussionmentioning

confidence: 99%

The role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region

Hossain¹,

Alam

Islam

et al. 2019

Birdem Med J

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Background: Undifferentiated tumours in the head and neck region are not uncommon. They can arise from different sites like in mucosa as well as in salivary glands, soft tissues or lymph nodes. Histopathological examination plays a central role in the diagnosis but difficulties arise with some tumours which are poorlydifferentiated due to their high inter- and intra-observer variability. In those cases, immunohistochemistry has greatly assisted to diagnose the tumours that cannot be accurately identified using routine histopathological procedures. The correct histopathological diagnosis is essential especially in case of malignant tumourwhere subsequent specific therapy is required. The aim of this study was to determine the role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region. Methods: This cross-sectional study was conducted during July 2014 to June 2015. A total of 35 Bangladeshi patient’s specimens of head and neck swelling were collected from two renowned laboratories in Dhaka city.These cases were diagnosed as undifferentiated tumour in histopathological examination.Standard protocol was followed for immunohistochemistry.Then primary immunohistochemical panel which included the markers for Epithelial CK (AE1/AE3),mesenchymal marker (Vimentin) and lymphoid marker (LCA) were used.The cases which were not resolved by primary immunohistochemistry panel, the second panel was applied for further sub classification (Desmin, Chromogranin, CK20, CEA, CD20, CD30, HMB45, NSE). Based on interpretation of immunohistochemical findings final diagnoses were made.Data analysis was performed using the Statistical Package for the Social Sciences for Windows version 22.0 (SPSS, Chicago, Illinois, USA). Results: A total of 35 undifferentiated tumorsof head-neck region were studied.The mean age was 46.3±17.6 years and male to female ratio was 4.8:1. The majority 13 (37.1%) patient had cervical lymphadenopathy, 11 (31.4%) had neck mass and 4(11.4%) had in nasal/sinonasal mass.Regarding histopathologicalcell types, round cell was 21 (60.0%), spindle cell 6 (17.1%), pleomorphic cells 6(17.1%) and epithelioid cells 2(5.7%). In initial histopathological examination, majority 25(71.4%) were undifferentiated malignant neoplasm, 8(22.8%) were metastatic undifferentiated carcinoma, 1(2.9%) was pleomorphic sarcoma and the remaining 1(2.9%) had malignant adnexal tumour. By application of immunohistochemistry, most (33, 94.3%) of the cases were resolved and the two cases remained unresolved. Among the resolved cases majority (15, 45.5%) were lymphoma, 4(12.1%) were metastatic carcinoma, 3(9.1%) were Ewing’s sarcoma and malignant melanoma were found in 3(9.1%) cases. Conclusion: This study supports that the immunohistochemical technique has a fundamental role in the investigation of undifferentiated tumour origin, to determine the correct guidance for treatment and improving the prognosis for head and neck tumour patients. Birdem Med J 2020; 10(1): 48-53

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“…In this regard, Bhagat et al could categorize 98.65%, Vege DS et al could categorize 85.5%, 7 Coindre JM et al (1986) could categorize 90%, while Michie et al (1987) could arrive at a diagnosis in 86% of undifferentiated tumours, by immunohistochemistry. In the study by Bianchini et al, immunohistochemistry allowed a conclusive diagnosis for 60.5% of tumours, 8 and was suggestive for 20.9%.…”

Section: Discussionmentioning

confidence: 99%

Immuno Histochemical Approach to the Diagnosis of Undifferentiated Tumours- An Institutional Study

Gouda¹,

Harankhedkar²,

Das³

et al. 2018

jebmh

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Undifferentiated Tumors: An Immunohistochemical Analysis on Biopsies

Cited by 13 publications

References 21 publications

Clinico-pathological profile of head and neck malignancies at University College Hospital, Ibadan, Nigeria

Clinico-pathological profile of head and neck malignancies at University College Hospital, Ibadan, Nigeria

The role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region

Immuno Histochemical Approach to the Diagnosis of Undifferentiated Tumours- An Institutional Study

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