Undetectable serum IgA and low IgM concentration in children with congenital hypothyroidism

Stagi, Stefano; Azzari, Chiara; Bindi, Giuseppe; Galluzzi, F.; Nanni, Sergio; Salti, R; Vierucci, A

doi:10.1016/j.clim.2005.03.003

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…In line with this, reduced total BM cell numbers have been demonstrated in T3Rα −/− mice, and thyroid hormones have been found to stimulate pro-B lymphocyte proliferation, thereby increasing total numbers of B lymphocyte progenitors [36,49]. Moreover, hypothyroidism in humans is also associated with decreased bone marrow output [50]. Based on these data we hypothesized that increased thyroid hormone levels in GD influence bone marrow activity and thereby contribute to the increased transitional and pre-naive B lymphocyte numbers that we found in the peripheral blood from GD patients.…”

Section: Discussionmentioning

confidence: 72%

The peripheral blood compartment in patients with Graves' disease: activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes

Weerd

Hagen

Schrijver

et al. 2013

Clinical and Experimental Immunology

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SummaryGraves' disease (GD) is an autoimmune disease that involves aberrant B and T lymphocyte responses. Detailed knowledge about lymphocyte subpopulation composition will therefore enhance our understanding of the pathogenesis of GD and might support the development of new immunomodulatory treatment approaches. The aim of this study was to gain detailed insight into the composition of the peripheral blood lymphocyte compartment in GD before and during anti-thyroid drug therapy. Major B and T lymphocyte subpopulations were investigated by flow cytometry in peripheral blood from newly diagnosed GD patients (n = 5), GD patients treated with anti-thyroid drugs (n = 4), patients with recurrent GD (n = 7) and healthy controls (HC; n = 10). In GD patients, numbers of activated T lymphocytes [human leucocyte antigen D-related (HLA-DR) + and CD25 + ] were increased. The B lymphocyte compartment in GD was characterized by significantly higher numbers of transitional (CD38 high CD27 − , P < 0·03) and pre-naive mature (CD38 low CD27− IgD + CD5 + , P < 0·04) B lymphocytes, while memory populations were slightly decreased. The increased numbers of CD5 + , transitional and pre-naive mature B lymphocytes correlated positively with fT4 plasma levels. GD is associated with increased numbers of activated T lymphocytes and transitional and pre-naive mature CD5 + B lymphocytes within the peripheral blood. The increase in CD5 + B lymphocytes was due mainly to an increase in transitional and pre-naive mature B lymphocytes. Increased fT4 plasma levels might be associated with this increase in transitional and pre-naive mature CD5 + B lymphocytes.

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Section: Discussionmentioning

confidence: 72%

The peripheral blood compartment in patients with Graves' disease: activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes

Weerd

Hagen

Schrijver

et al. 2013

Clinical and Experimental Immunology

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“…On the other hand, ATDs transmitted through the placenta or milk have been shown to expose the fetuses/neonates to a risk of hypothyroidism [2]. The disruption of perinatal thyroid function causes disorders in many networks, including the central nervous system [3] and the immune system [4]. In addition, previous studies have revealed that certain flame retardants might act on the developing thyroid system [5], suggesting that some environmental contaminants may modulate the balance of these thyroid function-related networks [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of rats

Nakamura

Teshima

Hachisuka

et al. 2007

International Immunopharmacology

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“…Data from hypothyroidism in humans [31] , or experimentally induced hypothyroidism in rodents, have been shown to diminish thymic activity, effects that were reversed by treatment with thyroid hormones [32] . In addition, hypothyroid experimental conditions lead to spleen and lymph node involution, as well as to depressed humoral and cell-mediated immune responses [33,34] .…”

Section: Consequences Of Aitd Endocrine Alterations On Immunitymentioning

confidence: 99%

Immune-Endocrine Interactions in Autoimmune Thyroid Diseases

Klecha¹,

Arcos

Frick

et al. 2008

Neuroimmunomodulation

101

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Autoimmune thyroid diseases (AITD) are the most common organ-specific autoimmune disorders affecting approximately 5% of the overall population. An aberrant interaction between abnormal thyrocytes, abnormal antigen-presenting cells and abnormal T cells forms the basis for the atypical autoimmune reaction targeting thyroid antigens. It was proposed that nongenetic (environmental and hormonal) factors play a crucial etiological role in AITD development, through altering immune-endocrine interactions. The most outstanding fact is that in genetically predisposed individuals, the disruption of these neuroendocrine-immune interactions by environmental factors results in thyroid autoimmune dysfunction. These interactions are able to incline the balance between Th1-Th2 immune response toward one side, resulting in a Th1-cell-mediated autoimmune reaction with thyrocyte destruction and hypothyroidism in Hashimoto’s thyroiditis but to a hyperreactive Th2-mediated humoral response against TSH receptor with stimulatory antibodies leading to Graves’ disease hyperthyroidism. In this review the main mechanisms involved are summarized. In this sense, the participation of stress-mediated activation of the sympathoadrenal system and hypothalamic-pituitary-adrenal axis, the hormonal changes occurring during pregnancy and postpartum acting on antigen-presenting cells and influencing, in this way, the balance of the immune status are shown to participate in AITD etiology. The possibility that altered levels of thyroid hormones during the course of the AITD may alter immune function is also discussed.

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Undetectable serum IgA and low IgM concentration in children with congenital hypothyroidism

Cited by 13 publications

References 26 publications

The peripheral blood compartment in patients with Graves' disease: activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes

The peripheral blood compartment in patients with Graves' disease: activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes

Effects of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of rats

Immune-Endocrine Interactions in Autoimmune Thyroid Diseases

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