Effects of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of rats

Nakamura, Ryosuke; Teshima, Reiko; Hachisuka, Akiko; Sato, Yuji; Takagi, Kayoko; Nakamura, Rika; Woo, Gye‐Hyeong; Shibutani, Makoto; Sawada, Jun‐ichi

doi:10.1016/j.intimp.2007.08.012

Cited by 20 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in accordance to the data obtained by other authors that used slightly different methods of hypothyroidism induction [3,6]. The most convincing evidence that development of T and B lineage is thyroid hormone dependent came from two studies: one on Snell dwarf mice (multiple hormonal defi cits), that recover B lymphocyte lineage after substitution of thyroid hormones [18] and the other on experiments demonstrating that deletion of genes for thyroid receptors result in an decreased number of T and B lymphocytes, macrophages and granulocytes in the spleen and other lymphoid organs [19].…”

Section: Discussionsupporting

confidence: 93%

“…Further on, it became evident that the lack of TSH preferentially decreased the number of pre-B lymphocytes in the mice bone marrow but, curiously, only the innate immune response was impaired [5]. Furthermore, depending on the model used, and severity of hypothyroidism, various results have been reported including a normal or decreased number of T cells and macrophages [3,6,7]. No study reported the increase in other cellular types.…”

Section: Introductionmentioning

confidence: 99%

“…The domestic animal species that is most commonly diagnosed to have hypothyroidism is the dog, but there is no data on what would be the effect of canine maternal hypothyroidism on their pups and specifi cally on their immunological status. Although the association between hypothyroidism and immunity is demonstrated [3,6,7], the importance of TH for the maturation of the spleen tissue compartments in the period of prenatal development, neonatal and juvenile periods have received little attention. A normally developed spleen should be the prerequist for normal clearance of circulating pathogens and thus the protection of animal from sepsis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stereological and Immunohistochemical Study of the Spleen in Hypothyroid Juvenile Rats

et al. 2015

View full text Add to dashboard Cite

The purpose of this work was to investigate the infl uence of hypothyroidism on spleen tissue morphology and immune cell density in fourteen-day-old juvenile rats. Hypothyroidism in pups (n=10) was induced by administration of propylthiouracil (PTU) in drinking water (1.5 mg/L) to their mothers during pregnancy and period of lactation. Fourteen-day-old pups were sacrifi ced and the thyroid-stimulating hormone (TSH) serum concentration and thyroid activation index (Ia) were determined. Increased serum level of TSH and increased Ia showed that pups from PTU treated mothers were hypothyroid. White and red spleen pulp, marginal zone and connective tissue volume density has been assessed by using the stereological method. Using immunohistochemistry, the present CD3+ T lymphocytes, CD45RA+ B lymphocytes and CD68+ macrophages were quantifi ed. A signifi cant reduction of volume density of the periarteriolar lymphocyte sheath (Vv PALS ) and lymphatic follicles (Vvf) due to depletion of T and B lymphocytes respectively, was observed in the spleens of hypothyroid pups compared to controls. The volume density of the red pulp (Vvrp), marginal zone (Vvmz) and connective tissue (Vvct) was increased, as well as the number of CD68+ macrophages in the spleens of hypothyroid pups compared to controls. These results indicate that thyroid hormones might be important for normal development of both, specifi c and innate immune cells in the spleen during prenatal and early postnatal period.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stereological and Immunohistochemical Study of the Spleen in Hypothyroid Juvenile Rats

et al. 2015

View full text Add to dashboard Cite

show abstract

“…There is evidence of the thyroid hormones and immune systems and their development and function from amphibious animals to mammals (Rollins-Smith & Blair, 1990;Lam et al, 2005;Watanabe et al, 1995;Nakamura et al, 2007).…”

Section: Thyroid Hormone Alteration Levels and The Immune Responsementioning

confidence: 99%

The Relationship Between Thyroid States, Oxidative Stress and Cellular Damage

Cano-Europa¹,

Blas-Valdivia²,

Franco-Colín³

et al. 2012

Oxidative Stress and Diseases

View full text Add to dashboard Cite

“…However, little information exists on the reproductive effects of DBDE. Furthermore, regulation of the developing immune system by thyroid hormone 10,11) and the effects of experimentally induced hypothyroidism in adult mice on the immune response have been reported, 12) although the developmental effects of DBDE on the immune system have not yet been examined. We therefore investigated the effects of DBDE on the developing immune system in rats to determine the safe dose of the compound.…”

Section: Introductionmentioning

confidence: 99%

Effects of Exposure to Decabromodiphenyl Ether on the Development of the Immune System in Rats

Teshima

Nakamura

et al. 2008

JOURNAL OF HEALTH SCIENCE

Self Cite

View full text Add to dashboard Cite

To evaluate the developmental toxicity of decabromodiphenylether (DBDE) after exposure during the period from late gestation to after lactation, maternal Sprague-Dawley rats were given DBDE at dietary concentrations of 0, 10, 100, and 1000 ppm from gestational day 10 (GD 10) to postnatal day (PND) 21. On PND 21 and 77, lymphocytes (Lymph) in the spleen, thymus, and peripheral blood of male pups were subjected to flow cytometric analyses for expression of surface markers [CD3, CD4, CD8a, CD25, CD45RA, CD71, and CD161(NKRP1A)]. On PND 21, the proportions of splenic CD4+ T cells in the 10-ppm group, activated B (CD45RA+CD71+) cells in the 100-to 1000-ppm groups, and activated T cells (CD3+CD71+) in the 1000-ppm group were significantly decreased, and the population of peripheral CD161+ natural kiler cells on PND 21 and 77 had decreased in the 100-to 1000-ppm groups. In the 1000-ppm group, the serum T3 level was significantly decreased on PND 21 and the serum T4 level was decreased on PND 77. The body, spleen, and thymus weights were not significantly decreased, but liver weight was significantly increased on PND 21 in the 10-to 1000-ppm groups. These results suggest that on PND 21, developmental exposure to the highest dose of DBDE had a weak immunomodulatory effect. Although the most of the immunomodulatory effect had recovered to normal levels on PND 77, a decreasing effect on the natural killer (NK) cell population remained.

show abstract

Effects of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of rats

Cited by 20 publications

References 22 publications

Stereological and Immunohistochemical Study of the Spleen in Hypothyroid Juvenile Rats

Stereological and Immunohistochemical Study of the Spleen in Hypothyroid Juvenile Rats

The Relationship Between Thyroid States, Oxidative Stress and Cellular Damage

Effects of Exposure to Decabromodiphenyl Ether on the Development of the Immune System in Rats

Contact Info

Product

Resources

About