Underutilization of norovirus testing in hematopoietic cell transplant recipients at a large cancer center

MacAllister, Trenton; Stednick, Zach; Golob, Jonathan L.; Huang, Meei‐Li; Pergam, Steven A.

doi:10.1016/j.ajic.2017.06.010

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…These results align with those of prior studies suggesting that GIS are often misdiagnosed as other infections, including C. difficile. 17,18 Thus, education of staff is of critical importance, especially during norovirus season, to identifying cases and to implementing infection prevention strategies as soon as infections begin to occur. Electronic systems can be leveraged for early case ascertainment and intervention by helping to identify cases early in their course and to encourage testing and isolation before substantial environmental contamination and nosocomial transmissions have occurred.…”

Section: Discussionmentioning

confidence: 99%

Identification of a norovirus outbreak on a hematopoietic stem cell transplant unit and development and implementation of a novel infection prevention algorithm for controlling transmission

Branch‐Elliman

Araujo‐Castillo

Sullivan

et al. 2020

Infect. Control Hosp. Epidemiol.

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Section: Discussionmentioning

confidence: 99%

Identification of a norovirus outbreak on a hematopoietic stem cell transplant unit and development and implementation of a novel infection prevention algorithm for controlling transmission

Branch‐Elliman

Araujo‐Castillo

Sullivan

et al. 2020

Infect. Control Hosp. Epidemiol.

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Human noroviruses: recent advances in a 50-year history

Atmar

Ramani

Estes

2018

Current Opinion in Infectious Diseases

106

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Norovirus epidemiology is complex and requires continued surveillance to track the emergence of new strains and recombinants, especially with the continued progress in vaccine development. Humans are the best model to study disease pathogenesis and prevention. New in-vitro cultivation methods should lead to better approaches for understanding virus-host interactions and ultimately to improved strategies for mitigation of human norovirus-associated disease.

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Presentation, management, and outcomes of norovirus in adult and pediatric solid organ and hematopoietic stem cell transplant recipients: A multicenter, retrospective study

Callegari,

Danziger‐Isakov,

Rose

et al. 2024

Transplant Infectious Dis

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BackgroundNorovirus (NoV) can cause chronic relapsing and remitting diarrhea in immunocompromised patients.  Few multicenter studies have described the clinical course, outcomes, and complications of chronic NoV in transplant recipients.MethodsA multicenter retrospective study of adult and pediatric SOT and HSCT recipients diagnosed with NoV between November 1, 2017, and February 28, 2021. Data were obtained from electronic medical records (EMR) and entered into a central REDCap database. Descriptive statistics were calculated.ResultsA total of 280 NoV+ patients were identified across eight sites. The majority were adults (74.1%) and SOT recipients (91.4%). Initial diagnosis of NoV occurred a median of 36 months post‐Tx (IQR [15.0, 90.0]). Most NoV cases had >3 diarrheal episodes daily (66.0%), nausea and vomiting (60.1%). Duration of diarrhea varied greatly (median = 10 days, mean = 85.9 days, range (1, 2100)). 71.3% were hospitalized. Adjustment of immunosuppression, including reduction and discontinuation of mToR inhibitor, CNI, and/or MMF, was the most common management intervention for NoV. Other therapies resulted only in temporary improvement. Four patients died within 30 days and three others died by 180 days postdiagnosis. Clinically significant renal dysfunction was observed in 12.5% by 30 days and 21.4% by 180 days post‐NoV diagnosis.ConclusionIn HSCT and SOT patients, NoV frequently resulted in severe symptoms, prolonged diarrhea (30% persistent with diarrhea for >30 days), and clinically significant renal dysfunction (up to 21% of patients). Utilized therapies did not reliably result in the resolution of infection demonstrating the need for more effective treatment. image

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Underutilization of norovirus testing in hematopoietic cell transplant recipients at a large cancer center

Cited by 3 publications

References 11 publications

Identification of a norovirus outbreak on a hematopoietic stem cell transplant unit and development and implementation of a novel infection prevention algorithm for controlling transmission

Identification of a norovirus outbreak on a hematopoietic stem cell transplant unit and development and implementation of a novel infection prevention algorithm for controlling transmission

Human noroviruses: recent advances in a 50-year history

Presentation, management, and outcomes of norovirus in adult and pediatric solid organ and hematopoietic stem cell transplant recipients: A multicenter, retrospective study

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