Understanding the Tabletting Characteristics of Ficus deltoidea Powder by Fitting into Compression Models

Abstract

The objective of this paper was to investigate the characteristics of Ficus deltoidea powders during tablet formation using a direct compression method. To understand the data further, compression models were fitted, which included those of Heckel, Kawakita, Adams and Panelli-Filho. F. deltoidea is well-known for its therapeutic properties when used in the form of an extracted powder. We further investigated the effect of the binders Avicel and Acdisol, which are known as a universal binder and a superdisintegrant, respectively. The physical properties, flowability and particle structures were determined to compare behavior and as references to the compression models used. The data were mostly consistent with those predicted by the compression models. As a result, applying compression models, especially the Kawakita model, was successfully performed and can be further related to the development and production of compact F. deltoidea tablets. Thus, this paper provides a fundamental understanding on the tabletting characteristics of F. deltoidea extract powder. PRACTICAL APPLICATIONSIn this study, a direct compression method was adopted to form the Ficus deltoidea extract powder into tablets. For further investigation, the F. deltoidea extract powder was mixed with two different binders, Avicel and Acdisol, in different ranges of composition. Hence, the pressure and effect of various process variables such as the food powder on tablet density and strength were obtained. For this reason, a study was conducted to increase our understanding of the tablet characteristics of F. deltoidea powder and binders by fitting the data into compression models. Four models had been proposed to reflect the physical and mechanical properties of powders and how these characteristics can be successfully applied in research. Finally, the best fitting compression model was chosen for further development and production of F. deltoidea compact tablets.

Processing of Moringa leaves as natural source of nutrients by optimization of drying and grinding mechanism

“…The flow of powder is often varying considerably and sometimes unpredictable (Staniforth & Taylor, ). Dried leaves are restricted to use in the wholesome form and powder flow becomes difficult during manufacturing processes of tablets, capsules, and other pharmaceutical procedures due to low bulk density, lose, and fluffy structure, high caking strength, cohesiveness, low tensile strength during compression, and generally poor flowability (Salleh et al, ). The presence of resins and gums in leaves may cause poor flowability.…”

Food Powders: Properties and Characterization

“…Tozlar›n ak›flkanl›¤›, bir k›s›m toz kütlesinin toz y›¤›n›n›n içerisinde komflu toz kütlesi üzerinde veya içinde bulunduklar› depolama ünitelerinin duvar yüzeyleri üzerindeki k›smi hareketi veya basitçe akma kabiliyeti olarak tan›mlanm›flt›r (8). G›da tozlar›n›n ak›flkanl›¤›, parçac›k fiziksel özelliklerine (boyut, flekil) ve yüzey kimyasal bileflimine büyük oranda ba¤l›d›r (4,10).…”

Development of Nutraceutical Product

“…Some of the factors that affect flowability of bulk solids and powders include moisture content, humidity, temperature, pressure, fat, particle size, and flow agents. Fig 3 shows the powder flow function of Ficus deltoidea, Acdisol and Avicel adapted from [21]. Here it was noticed that Acdisol and Avicel flow function lines showed better flowability with increase in major consolidation stress (MCS) compared to Ficus deltoidea.…”

“…3 Powder flow functions. Source: [21] VI. DISSOLUTION Dissolution is a process by which a solid solute enters a solution.…”