Understanding regeneration at different scales

MacCord, Kate; Maienschein, Jane

doi:10.7554/elife.46569

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…(the compensation of cell or tissue loss during embryogenesis), "homeostatic regeneration" (periodic loss and replacement of cells and tissues such as the gut lining, epidermis, hair, feathers and antlers turn-over) and "restorative regeneration" (replacement of lost body parts or the entire body), respectively [7,8]. It is noteworthy that the term "regeneration" is also used for both unicellular organisms and microbial communities, or even ecosystems [9]. We will however restrict our discussion to restorative regeneration processes of individual metazoans in this review.…”

Section: Concept and Definitionmentioning

confidence: 99%

Animal regeneration in the era of transcriptomics

Bideau

Kerner

Hui

et al. 2021

Cell. Mol. Life Sci.

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Animal regeneration, the ability to restore a lost body part, is a process that has fascinated scientists for centuries. In this review, we first present what regeneration is and how it relates to development, as well as the widespread and diverse nature of regeneration in animals.Despite this diversity, animal regeneration includes three common mechanistic steps: initiation, induction and activation of progenitors, and morphogenesis. In this review article, we summarize and discuss from an evolutionary perspective the recent data obtained for a

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Section: Concept and Definitionmentioning

confidence: 99%

Animal regeneration in the era of transcriptomics

Bideau

Kerner

Hui

et al. 2021

Cell. Mol. Life Sci.

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“…As we have seen already, distinguishing regeneration from degradation requires looking for restoration or impediment of some aspect of the system in question (MacCord and Maienschein 2019;Vásquez-Grandón et al 2018). To determine if aspects of a system have been impeded or restored, a reference point is required.…”

Section: Regeneration Degradation and Baselinesmentioning

confidence: 99%

“…Unlike the cases above, this account applies to reefs as ecosystems, rather than organisms or cells. That there are similarities across cellular biology, medical biology and ecology also suggests that the role for value outlined here may apply in cases of regeneration at different scales, thereby potentially forming part of an account of regeneration across living systems generally 3 (MacCord and Maienschein 2019).…”

Section: Introductionmentioning

confidence: 97%

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Distinguishing regeneration from degradation in coral ecosystems: the role of value

Jones

2021

Synthese

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In this paper I argue that the value attributed to coral reefs drives the characterisation of evidence for their regeneration or degradation. I observe that regeneration and degradation depend on an understanding of what an ecosystem looks like when undegraded (a baseline), and that many mutually exclusive baselines can be given for any single case. Consequently, facts about ecological processes are insufficient to usefully and non-arbitrarily characterise changes to ecosystems. By examining how baselines and the value of reefs interact in coral and algal reef examples, I argue that considering the value of an ecosystem is a necessity when describing processes like regeneration and degradation. This connects value as studied in socio-ecological and economic research with values as discussed in the philosophy of science literature. It also explains why such a broad range of processes may be considered regenerative, including those which introduce significant novelty, as well as pointing towards ways to mediate related debates, such as those surrounding novel and ‘pristine’ ecosystems.

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“…Diverse living systems possess the capacity for regeneration; that is, they can under some circumstances repair, re-produce, and maintain themselves in the face of disturbance or damage (Birnbaum and Alvarado 2008;MacCord and Maienschein 2019). Think of systems as diverse as forests, microbial biofilms, corals, salamanders, hydra, and human skin cells.…”

mentioning

confidence: 99%

20220112

Inkpen¹,

Doolittle²

2021

Philosophy, Theory, and Practice in Biology

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Here we endorse Hull's replicator/interactor framework as providing the overarching understanding sought by MacCord and Maienschein. We suggest that difficulties in seeing the regeneration of limbs by salamanders and of forest ecosystems after fires as similar evolutionary processes can be overcome in this framework. In generalizing Dawkins's "selfish gene" perspective, Hull defined natural selection as "a process in which the differential extinction and proliferation of interactors causes the differential perpetuation of the replicators that produced them". Although genes and bacteria are simultaneously both replicators and interactors, communities and ecosystems are generally only interactors. As reproducers, members of sexual species are intermediate. Within such species, organisms are indeed the interactors whose "differential extinction and proliferation" causes the "differential perpetuation" of replicators (genes). But sexually-reproducing organisms do not individually replicate, persist, or recur as interactors, and in consequence it is only those genes causing an interactor differential that are specifically perpetuated in the long run. Higher-level interactors (multi-species communities and ecosystems) may seldom if ever reproduce, but their recurrence does enable the "differential perpetuation" of replicators specifically responsible for their "differential extinction and proliferation". In offering answers to the question "What are the replicators specifically responsible for the differential extinction and proliferation of such higher-level entities?" we hope to unify adaptive regeneration across scales, from organisms to ecosystems.

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Understanding regeneration at different scales

Cited by 6 publications

References 9 publications

Animal regeneration in the era of transcriptomics

Animal regeneration in the era of transcriptomics

Distinguishing regeneration from degradation in coral ecosystems: the role of value

20220112

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