Animal regeneration in the era of transcriptomics

Bideau, Loïc; Kerner, Pierre; Hui, Jerome H. L.; Vervoort, Michel; Gazave, Eve

doi:10.1007/s00018-021-03760-7

Cited by 35 publications

(40 citation statements)

References 178 publications

(236 reference statements)

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“…The effect of these secreted factors on the stimulation of cell division and the development of the regenerate has been well described for the model of vertebrate limb regeneration [115][116][117]. The repertoire of these molecules in annelids is poorly characterized, but some pioneering data suggest their relevance for regeneration [46,118,119], and so do the observations on the suppression of proliferation in a denervated wound [10,40,82]. Neurotransmitters are an important NS-derived factor, but their role in annelid regeneration remains almost unexplored [120,121].…”

Section: Nervous Systemmentioning

confidence: 99%

Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration

Kostyuchenko

Kozin

2021

Genes

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The question of why animals vary in their ability to regenerate remains one of the most intriguing questions in biology. Annelids are a large and diverse phylum, many members of which are capable of extensive regeneration such as regrowth of a complete head or tail and whole-body regeneration, even from few segments. On the other hand, some representatives of both of the two major annelid clades show very limited tissue regeneration and are completely incapable of segmental regeneration. Here we review experimental and descriptive data on annelid regeneration, obtained at different levels of organization, from data on organs and tissues to intracellular and transcriptomic data. Understanding the variety of the cellular and molecular basis of regeneration in annelids can help one to address important questions about the role of stem/dedifferentiated cells and “molecular morphallaxis” in annelid regeneration as well as the evolution of regeneration in general.

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Section: Nervous Systemmentioning

confidence: 99%

Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration

Kostyuchenko

Kozin

2021

Genes

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“…When an injury occurs, tissues and organs in the body experience a secondary development – regeneration by mobilizing the expression of genes that are originally activated only during development ( Lu et al, 2020 ; Wang et al, 2020 ). The other view is that development and regeneration are fundamentally different processes only with some overlapped cellular and genetic mechanisms ( Bideau et al, 2021 ). Our data reflect the first view that regeneration is a recapitulation of development and highlight that protein acetylation may be a mechanism for the association between development and regeneration.…”

Section: Discussionmentioning

confidence: 99%

Expression of Protein Acetylation Regulators During Peripheral Nerve Development, Injury, and Regeneration

Sun

Qingyun

et al. 2022

Front. Mol. Neurosci.

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Protein acetylation, regulated by acetyltransferases and deacetylases, is an important post-translational modification that is involved in numerous physiological and pathological changes in peripheral nerves. There is still no systematical analysis on the expression changes of protein acetylation regulators during sciatic nerve development, injury, and regeneration. Here, we sequenced and analyzed the transcriptome of mouse sciatic nerves during development and after injury. We found that the changes in the expression of most regulators followed the rule that “development is consistent with regeneration and opposite to injury.” Immunoblotting with pan-acetylated antibodies also revealed that development and regeneration are a process of increased acetylation, while injury is a process of decreased acetylation. Moreover, we used bioinformatics methods to analyze the possible downstream molecules of two key regulators, histone deacetylase 1 (Hdac1) and lysine acetyltransferase 2b (Kat2b), and found that they were associated with many genes that regulate the cell cycle. Our findings provide an insight into the association of sciatic nerve development, injury, and regeneration from the perspective of protein acetylation.

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“…Polychaete annelid worms, and in particular the nereids, are easy to experiment with, and existing genomic data make it a model of renewed interest for tail regeneration. 14 The body of Nereidae (Figure 1 A) is a long chain of segments largely similar along the body between two terminal parts, the prostomium (fused with the peristomium, corresponding in part to the first segment, to form the head with the mouth) anteriorly, and the pygidium with the anus posteriorly, both representing the two parts of the young trochophore larva. All segments, at the exception of the prostomium, peristomium, and pygidium bear a pair of lateral appendages called parapodia.…”

Section: Nereids As a Regeneration Modelmentioning

confidence: 99%