Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

Ortega, Miguel Á.; Fraile-Martínez, Óscar; García-Montero, Cielo; Álvarez-Mon, Miguel Ángel; Chen, Chao-Wen; Ruiz-Grande, Fernando; Pekarek, Leonel; Monserrat, Jorge; Asúnsolo, Ángel; García‐Honduvilla, Natalio; Álvarez‐Mon, Melchor; Buján, Julia

doi:10.3390/jcm10153239

Cited by 89 publications

(45 citation statements)

References 311 publications

(336 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The pathophysiology of CVeD involves a profound remodeling and injury of the venous wall, valve incompetence, microcirculatory changes, hypoxia, and a significant inflammatory response secondary to venous hypertension [252]. Women, especially those who are pregnant, represent a vulnerable population that suffers from CVeD [253]. Due to the differential hemodynamic activities occurring in the cardiovascular system, exposure to different hormonal factors, and mechanical action due to proper growth of the fetus, approximately 40% of women undergo CVeD during pregnancy [252].…”

Section: Chronic Venous Disease Clinical Manifestations and Repercuss...mentioning

confidence: 99%

The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease

Ortega

Fraile-Martínez

García-Montero

et al. 2022

Cells

Self Cite

View full text Add to dashboard Cite

The placenta is a central structure in pregnancy and has pleiotropic functions. This organ grows incredibly rapidly during this period, acting as a mastermind behind different fetal and maternal processes. The relevance of the placenta extends far beyond the pregnancy, being crucial for fetal programming before birth. Having integrative knowledge of this maternofetal structure helps significantly in understanding the development of pregnancy either in a proper or pathophysiological context. Thus, the aim of this review is to summarize the main features of the placenta, with a special focus on its early development, cytoarchitecture, immunology, and functions in non-pathological conditions. In contraposition, the role of the placenta is examined in preeclampsia, a worrisome hypertensive disorder of pregnancy, in order to describe the pathophysiological implications of the placenta in this disease. Likewise, dysfunction of the placenta in fetal growth restriction, a major consequence of preeclampsia, is also discussed, emphasizing the potential clinical strategies derived. Finally, the emerging role of the placenta in maternal chronic venous disease either as a causative agent or as a consequence of the disease is equally treated.

show abstract

Section: Chronic Venous Disease Clinical Manifestations and Repercuss...mentioning

confidence: 99%

The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease

Ortega

Fraile-Martínez

García-Montero

et al. 2022

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

“…International studies have shown a high prevalence of chronic venous disease (75.2%) [3], with 40% of men and 32% of women suffering from varicose veins. According to Ortega and coworkers [4], the estimated prevalence of chronic venous disease was between 60-80%, and more than 80% of the total population suffered from minor venous disorders [5]. Bihari and coworkers [6] described the prevalence of lower limb varicose veins (57.1%) in Hungary, a value similar to other European countries.…”

Section: Introductionmentioning

confidence: 99%

Validity and Reliability of the Hungarian Version of Aberdeen Varicose Vein Questionnaire

Kiss

Szabó

Tékus

et al. 2022

IJERPH

View full text Add to dashboard Cite

Purpose: The aim of our study was to translate the Aberdeen Varicose Vein Questionnaire (AVVQ) into Hungarian, and to investigate the validity and reliability of the Hungarian AVVQ, as well as to assess the health-related quality of life in patients with varicose veins of the leg. Methods: 374 adults participated in this study who were divided into two groups (varicose vein, healthy). We analyzed internal consistency, convergent validity (using the 36-Item Short Form Survey, SF-36), repeatability, and intra-class correlation coefficient of the Hungarian AVVQ. Regarding discriminant validity, we determined the scores of the Hungarian AVVQ in both groups using the Mann-Whitney U-test. Results: The Cronbach-alpha value was 0.890, while the correlation coefficient was R = 1.000. According to the results of the convergent validation, the scores of pain and dysfunction moderately correlated with some scores of the SF-36. The score of cosmetic appearance had a relationship with many scores of the SF-36. We registered a significant relationship between the score of extent of varicosity and some scores of the SF-36. There was significant correlation between the score of complications and numerous scores of the SF-36 (physical functioning, role limitations due to physical health, pain and general health). The score of pain and dysfunction, cosmetic appearance, extent of varicosity, complications and total score of the Hungarian AVVQ showed a significant difference between both groups. Conclusions: The Hungarian AVVQ was a reliable and a valid tool to assess the health-related quality of life among patients with varicose veins and was a useful tool to justify the further treatment of the patients.

show abstract

“…This fact is explained by disruption of the morpho-functional state of endothelial cells, which leads to an inflammatory cascade with subsequent pathological changes in the walls of the veins. [4,5,6,7]…”

Section: Discussionmentioning

confidence: 99%

Age-Related Morphological Changes in Intima of Greatsaphenous Vein in Health and in Venous D

Abduvosidov¹,

Chudnikh²,

Astashov³

et al. 2021

ArveMED

View full text Add to dashboard Cite

Aim: To study and evaluate degree of morphological changes in intima of great saphenous vein (GSV) in patients of different age groups in health and in venous disease. Materials and methods: We investigated autopsy material of GSV in 60 deceased patients and postoperative material of GSV in 80 patients with venous disease. Four age groups were formed: young age, middle age, older and elderly age. Totally there were 280 GSV fragments. Histological, morphometric, electron microscopic and biochemical studies were performed. Results: Our results are mainly consistent with the reference data. However, we carried out a comparative study of intima structure in norm and with venous disease in patients of different age. At the same time due to agerelated decline in varicose veins morphological changes are progressing. There are areas of endothelium atrophy and signs of fibrotic replacement in young and middle age patients with venous disease, whereas in older and elderly patients desquamation of endothelium and sclerosis were observed. Conclusion: Progressive degeneration in older and elderly patients with varicose veins promotes morphological changes of GSV and progression of the disease on histological and ultrastructural level that worsens endothelial dysfunction.

show abstract

Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

Cited by 89 publications

References 311 publications

The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease

The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease

Validity and Reliability of the Hungarian Version of Aberdeen Varicose Vein Questionnaire

Age-Related Morphological Changes in Intima of Greatsaphenous Vein in Health and in Venous D

Contact Info

Product

Resources

About