Uncaria tomentosa (cat claw) Counteracts Chronic Fipronil-induced Endocrine Disruption Induced Insulin Resistance and Hepatic Damage in Male Albino Rats

Abstract

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Hepatoprotective Effect of Uncaria Tomentosa on Schistosoma Mansoni Experimental Infection Through Reduction of Nuclear Factor Kappa B

“…Thus, the present study showed best levels improvement in the ALT & AST in U. tomentosa received mice. This agreed with Abdelrazek et al (2017) they reported that the hepatotoxic substance fipronil improved ALT & AST in U. tomentosa treated mice. Moreover, Al-khayyal et al (2019) who reported hepatic injury were improved by carbon tetrachloride.…”

“…But the significant difference between U. tomentosa treated group and PZQ treated group confirmed the ability of this extract to reduce granuloma diameter and protect the liver from damage. To our knowledge, none published about the relation between U. tomentosa extract and the S. mansoni granuloma diameter, but others supported the hepatoprotective effects of this extract and reduction of liver damage caused by hepatotoxic substances as fipronil (Abdelrazek et al, 2017) and carbon tetrachloride (Al-khayyal et al, 2019), as well as hepatoprotective effect due to its high antioxidant efficacy that prevented the inducible nitric oxide synthase gene expression (Batiha et al, 2020).…”

Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects

“…In a recent study, Uncaria tomentosa administered for six consecutive weeks protected the rats against fipronil-induced liver damage by reduction of cytokines production and inhibiting the NF-κB level [62]. The administration of Uncaria tomentosa at a dose of 5g/kg/day in rats for three months controlled fipronil-induced metabolic dysfunction [63].…”