Ultraviolet Light Factor in Chlorpromazine Dermatitis

Cahn, Milton M.

doi:10.1001/archderm.1957.01550130040002

Cited by 31 publications

(3 citation statements)

References 3 publications

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“…Results which are apparently at variance with ours are those of Cahn and Levy (1957), Epstein et al (1957) and Satanove and McIntosh (1967), all of whom used humans and considered the active wavelengths were in the sunburn region. Satanove and McIntosh (1967) were able to test a particularly interesting and imjjortant group of patients, a considerable number of psychotics who had been taking oral CP in higli dosage (at least 400 mg./day) for long periods.…”

Section: Discussioncontrasting

confidence: 57%

Chlorpromazine Photosensitivity in Mice: Its Action Spectrum and the Effect of Anti-Inflammatory Agents

Hunter¹,

Bhutani²,

Magnus

1970

Br J Dermatol

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SUMMARY.— The photosensitizing action spectrum of chlorpromazine (CP) has been investigated in hairless mice. Our results suggest that CP photosensitivity in this animal has a broad action spectrum in the longwave u.v. spectrum, viz. from 330 to 370–380 nm., with peak activity at wavelengths just above normal sunburn wavelengths. In other words we could establish photosensitization activity of the drug at wavelengths which it is known to absorb that are longer than about 320 nm.; we were unable to demonstrate a lowering of threshold response in the presence of the drug when normal sunburn wavelengths were used. Both soya bean trypsin inhibitor and e‐amino‐n‐caproic acid inhibited the specific photosensitivity reactions of immediate or early onset, due to CP. This result suggests that the reaction may be mediated through the action of a plasmin or “protease‐polypeptide” system. It is tentatively suggested that the mediators causing the normal sunburn reaction may differ from those causing CP photosensitivity.

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Section: Discussioncontrasting

confidence: 57%

Chlorpromazine Photosensitivity in Mice: Its Action Spectrum and the Effect of Anti-Inflammatory Agents

Hunter¹,

Bhutani²,

Magnus

1970

Br J Dermatol

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“…Photosensitivity seems to be primarily induced by contact exposure to promethazine hydrochloride cream [34]. Systemic use without topical sensitization does not appear to induce photosensitivity [35].…”

Section: The Phenothiazinesmentioning

confidence: 96%

Adverse Cutaneous Reactions of Systemic Antihistamines

Özkaya¹

2005

CMCAIAA

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Cutaneous adverse reactions to systemic antihistamines are rare but an important finding. The reaction may vary from an eczematous eruption as the most frequent type, to rare but severe reactions such as urticaria / angioedema, erythema multiforme / Stevens-Johnson syndrome or Lyell syndrome. This is a review of the reported types of cutaneous adverse reactions due to systemically administered old and new antihistamines.

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“…Most of the literature related to the phototoxic/photoallergic reactions of chlorpromazine date between the 1950s and 1980s. [2][3][4][5][6][7] After breakdown, chlorpromazine results in the formation of phenothiazine cation radicals, oxygen-centered radicals, carbon-centered radicals, and sulfur-centered peroxy radicals that are responsible for the photosensitization of the dermis, causing phototoxicity. [2] In 1981, Kochever reported that chlorpromazine-induced phototoxicity results in damage to the DNA as well as cell membrane [7] and that superoxides cause the DNA damage.…”

Section: Introductionmentioning

confidence: 99%

Chlorpromazine-induced severe exfoliative photoallergic reaction

Dhanasekaran

Kar

Yadav

2015

Int J Nutr Pharmacol Neurol Dis

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Despite the availability of newer antipsychotic drugs, chlorpromazine is still widely used due to its cost-utility and effectiveness in many parts of India, particularly for patients in whom marked psychomotor excitement and sleep disturbances are present. The side effects of chlorpromazine include photo-induced skin reactions. Chlorpromazine causes both phototoxic as well as photoallergic cutaneous reactions. We present the case report of an adult male who developed severe photoallergic skin reactions to chlorpromazine. The skin lesions largely resolved on stopping the drug, but reappeared in a more severe form when the drug was inadvertently restarted by the patient. This highlights the need for awareness and education of patients about the skin effects of psychotropics such as chlorpromazine.

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Ultraviolet Light Factor in Chlorpromazine Dermatitis

Cited by 31 publications

References 3 publications

Chlorpromazine Photosensitivity in Mice: Its Action Spectrum and the Effect of Anti-Inflammatory Agents

Chlorpromazine Photosensitivity in Mice: Its Action Spectrum and the Effect of Anti-Inflammatory Agents

Adverse Cutaneous Reactions of Systemic Antihistamines

Chlorpromazine-induced severe exfoliative photoallergic reaction

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