Ultrathin molecularly imprinted polymer sensors employing enhanced transmission surface plasmon resonance spectroscopy

Abstract

An ultrathin novel nanosensor (31.5 +/- 4.1 nm thick in the absence of analytes), employing a molecularly imprinted polymer as a recognition element for cholesterol and gold nanoparticle enhanced transmission surface plasmon resonance spectroscopy for detection, was constructed.

The rational development of molecularly imprinted polymer-based sensors for protein detection

“…Nanoparticle islands of gold on a glass substrate were employed for enhanced SPR, facilitated by plasmon coupling to gold nanoparticles embedded in a cholesterol-imprinted polymer film. 268 Re-binding of cholesterol led to a shift in the SPR angle.…”

Gold‐Nanoparticle‐Enhanced Plasmonic Effects in a Responsive Polymer Gel

“…Lee and Perez-Luna [21] reported the reversible aggregation of gold colloidal NPs linked to the chains of a dextran brush in solvents of different polarity and the associated changes in the optical properties. In our previous papers, [26,27] we have reported the enhanced sensitivity to changes in pH and cholesterol concentration of a poly(2-vinyl pyridine) (P2VP) brush grafted onto surface-immobilized gold islands, in which the optical effect was enhanced by adsorption of gold NPs on top of the brush. Stimuli-induced swelling/shrinkage of the polymer brush resulted in tuning the interaction between the gold islands localized at the grafting surface and gold nanoparticles adsorbed on the top of the brush.…”

“…[7,8] This technique was only recently employed for detecting stimuli-induced changes in polymeric materials. [20][21][22][23][24][25][26][27] In most cases, the conformational and chemical transitions in polymeric materials are accompanied by the modification of their dielectric function (e), which can be sensed using T-LSPR spectroscopy. In a typical configuration of a sensing element, metal NPs (e.g., colloids or islands) are immobilized as a monolayer on a glass substrate, while a polymer material is either deposited on top of the NP monolayer or grafted between NPs.…”

Electrochemical Nanotransistor from Mixed‐Polymer Brushes

“…Functional interfaces with switchable properties controlled by external physical signals (light, [1] electrical potential, [2] magnetic field [3] ) or chemical inputs (presence or absence of chemicals, variation of their concentrations) [4,5] have received considerable attention in the last two decades. Their applications for controlled surface wettability, [6,7] thin-films permeability, [8,9] catalysis, [10] and particularly for assembling modified electrodes, [11] used in switchable sensors, [12] fuel cells, [13] and memory units, [14] resulted in novel materials, devices, and systems.…”