Ultrathin 2D Metal–Organic Framework Nanosheets

Zhao, Meiting; Wang, Yixian; Ma, Qinglang; Huang, Ying; Zhang, Xiao; Ping, Jianfeng; Zhang, Zhicheng; Lu, Qipeng; Yu, Yifu; Xu, Huan; Zhao, Yanli; Zhang, Hua

doi:10.1002/adma.201503648

Cited by 1,026 publications

(895 citation statements)

References 51 publications

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“…Previous high-throughput array analyses have demonstrated that the expression of miRNAs present substantial variances in tumors [18,19]. Overexpression of miRNAs may contribute to its oncogenesis by downregulating tumor suppressors, whereas underexpression of miRNAs may negatively regulate oncogenes or factors related to tumorigenesis and progression [20]. Thus, we explore comprehensive miRNAs profile in NSCLC with LN metastasis.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

Xu¹,

Li²,

Li³

et al. 2015

Aging and disease

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Lymph node (LN) metastasis is often an early event in the progression of malignant tumors and it contributes to the majority of cancer mortalities. MiRNAs play key roles in tumor metastasis. This study aimed to investigate the specific miRNAs as putative indicators of metastasis early diagnosis for non-small cell lung cancer (NSCLC). In this study, five NSCLC cases with LN metastasis and four cases without metastasis (NLN) were enrolled for Agilent Human miRNA array. The interested differentially expressed miRNA was validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) in the LN metastasis (n = 46) and NLN (n = 39) groups. The microarray results revealed that three miRNAs (miR-1260b, miR-423-3p, miR-23a-5p) were differentially expressed in LN metastasis group compared with NLN group. The expression of miR-1260b was tested by qRT-PCR and the mean relative expression fold change (2 -ΔΔCt ) in LN metastasis was significantly higher than that in the NLN group (3.942, 1.743 respectively, P = 1.179E-04). The patients with tumor-node-metastasis (TNM) stage III were identified more frequently in LN metastasis group (P = 1.772E-11) and with a higher expression level of miR-1260b (5.126, P = 1.147E-06). In addition, the LN metastasis cases were associated with a poorly differentiated degree (P = 0.007). The overexpression of miR1260b in NSCLC with LN metastasis can be regarded as a specific signature for early progression and prognosis of NSCLC.

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Section: Discussionmentioning

confidence: 99%

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

Xu¹,

Li²,

Li³

et al. 2015

Aging and disease

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“…Most current synthesis has focused on three routes: 33 assembly at an interface, 30,34 synthesis of nanosheets in bulk solution, 31,32 and liquid-phase exfoliation of weakly bound 2D layered materials (including with the assistance of surfactants). 35,36 To the best of our knowledge, there have been no reports of the synthesis of nanosheets from 3D framework materials, as this requires the breaking of strong metal–ligand bonds. This work, by showing the feasibility of chemically selective cleavage of these strong bonds, suggests that harnessing the huge variety of 3D MOFs as precursors for metal–organic nanosheets is a promising strategy for the synthesis of new low-dimensional materials.…”

Section: Introductionmentioning

confidence: 99%

Metal–Organic Nanosheets Formed via Defect-Mediated Transformation of a Hafnium Metal–Organic Framework

et al. 2017

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We report a hafnium-containing MOF, hcp UiO-67(Hf), which is a ligand-deficient layered analogue of the face-centered cubic fcu UiO-67(Hf). hcp UiO-67 accommodates its lower ligand:metal ratio compared to fcu UiO-67 through a new structural mechanism: the formation of a condensed “double cluster” (Hf12O8(OH)14), analogous to the condensation of coordination polyhedra in oxide frameworks. In oxide frameworks, variable stoichiometry can lead to more complex defect structures, e.g., crystallographic shear planes or modules with differing compositions, which can be the source of further chemical reactivity; likewise, the layered hcp UiO-67 can react further to reversibly form a two-dimensional metal–organic framework, hxl UiO-67. Both three-dimensional hcp UiO-67 and two-dimensional hxl UiO-67 can be delaminated to form metal–organic nanosheets. Delamination of hcp UiO-67 occurs through the cleavage of strong hafnium-carboxylate bonds and is effected under mild conditions, suggesting that defect-ordered MOFs could be a productive route to porous two-dimensional materials.

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“…The recently reported strategies like calcinations at high temperature may sacrifice MOFs' intrinsic molecular metal active sites8, while hybridization with secondary conductive supports (polyaniline9, graphene10 and so on) may block their intrinsic micropores, and the bulk conductive MOF has limited meso- and macro-porosity (tens of nanometres to several micrometres) for effective mass transport during electrocatalysis7. Very recently, a few two-dimensional (2D) MOFs have been synthesized1112131415, but the majority of 2D MOFs reported to date have been prepared in powder form, and little effort has been devoted to increasing the macro-/meso-porosity, conductivity or number of catalytic centres.…”

mentioning

confidence: 99%

Ultrathin metal-organic framework array for efficient electrocatalytic water splitting

2017

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Two-dimensional metal-organic frameworks represent a family of materials with attractive chemical and structural properties, which are usually prepared in the form of bulk powders. Here we show a generic approach to fabricate ultrathin nanosheet array of metal-organic frameworks on different substrates through a dissolution–crystallization mechanism. These materials exhibit intriguing properties for electrocatalysis including highly exposed active molecular metal sites owning to ultra-small thickness of nanosheets, improved electrical conductivity and a combination of hierarchical porosity. We fabricate a nickel-iron-based metal-organic framework array, which demonstrates superior electrocatalytic performance towards oxygen evolution reaction with a small overpotential of 240 mV at 10 mA cm−2, and robust operation for 20,000 s with no detectable activity decay. Remarkably, the turnover frequency of the electrode is 3.8 s−1 at an overpotential of 400 mV. We further demonstrate the promise of these electrodes for other important catalytic reactions including hydrogen evolution reaction and overall water splitting.

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Ultrathin 2D Metal–Organic Framework Nanosheets

Cited by 1,026 publications

References 51 publications

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

Metal–Organic Nanosheets Formed via Defect-Mediated Transformation of a Hafnium Metal–Organic Framework

Ultrathin metal-organic framework array for efficient electrocatalytic water splitting

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