2014
DOI: 10.1007/s11999-013-3083-7
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Ultrastructure and Innervation of Thumb Carpometacarpal Ligaments in Surgical Patients With Osteoarthritis

Abstract: Background The complex configuration of the thumb carpometacarpal (CMC-1) joint relies on musculotendinous and ligamentous support for precise circumduction. Ligament innervation contributes to joint stability and proprioception. Evidence suggests abnormal ligament innervation is associated with osteoarthritis (OA) in large joints; however, little is known about CMC-1 ligament innervation characteristics in patients with OA. We studied the dorsal radial ligament (DRL) and the anterior oblique ligament (AOL), l… Show more

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Cited by 43 publications
(29 citation statements)
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“…5A-F) and thin volarly (Fig. 6A-D), both as measured in thickness and cellular content [45,62,65,75,109]. We have verified their presence from outside-in with gross dissection, and from inside-out with arthroscopic evaluation (Fig.…”
Section: Ligamentsmentioning
confidence: 57%
See 1 more Smart Citation
“…5A-F) and thin volarly (Fig. 6A-D), both as measured in thickness and cellular content [45,62,65,75,109]. We have verified their presence from outside-in with gross dissection, and from inside-out with arthroscopic evaluation (Fig.…”
Section: Ligamentsmentioning
confidence: 57%
“…Since the volar ligaments in our studies were deemed insufficient to provide static stability, we believe the thenar muscles, intimal to the volar capsule, are of primary importance in volar CMC joint stability. A followup study we performed examining the ligaments of 11 arthritic subjects at time of surgery (10 women, one man) confirmed the predominance of mechanoreceptors in the dorsal radial ligament and paucity in the anterior oblique ligament [75]. These subjects underwent surgery for symptomatic arthritis and thus may have altered neural and ligament structure compared to asymptomatic individuals; the causal relationship of symptoms, ligament pathology, and mechanoreceptors remains unclear.…”
Section: Ligamentsmentioning
confidence: 86%
“…Notable associations between self-reported pain and function have been reported for these patients. Furthermore, compared with healthy individuals, patients with this condition have reduced grip and pinch strength 32 , including a decrease in cylindrical grasp and key pinch strength that can begin in the early stages of disease 33,34 . Some of these presentations might be due to changes in the structure and composition of the joint and changes in the innervation of the dorsal radial ligament, which has an important proprioceptive and stabilising role for the thumb base 35 .…”
Section: [H1] Disease Presentation and Burdenmentioning
confidence: 99%
“…Unclassifiable corpuscles were the second most common mechanoreceptor type, suggesting a high morphologic variety of sensory nerve endings, also observed in other studies [18,26]. It also points to a possible limitation of the existing gold standard classification of Freeman and Wyke [4], modified by Hagert [8], because many sensory nerve endings apparently will not fit into the established and limited classification schemes.…”
Section: Limitationsmentioning
confidence: 53%