Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management

Marshall, Michelle; Watt, Fiona E.; Vincent, Tonia L.; Dziedzic, Krysia

doi:10.1038/s41584-018-0095-4

Cited by 141 publications

(138 citation statements)

References 239 publications

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“…The joints of the hand are the most affected joints in clinical OA and significantly decrease an individual's ability to perform activities of daily living (ADLs). In the United States, the prevalence of symptomatic hand OA is 16% of the population [6]. The progression from the onset of disease to symptoms is not fully understood, however, one study of the US population estimated the risk of developing clinically significant hand OA in at least one hand by 85 years was 47% in women, 25% in men, 41% in whites, 29% in African Americans, and 47% in obese individuals [7].…”

Section: Hand Osteoarthritismentioning

confidence: 99%

Injection Techniques for Common Chronic Pain Conditions of the Hand: A Comprehensive Review

et al. 2020

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Introduction: This compilation presents a comprehensive review of the literature on common chronic pain conditions of the hand. It briefly presents these common conditions with their biological background, diagnosis, and common management options. It then presents and compares the latest literature available for injection techniques to treat these diagnoses and compares the available evidence. Methods: A comprehensive literature review was performed in MEDLINE, PubMed, and Cochrane databases from 1996 to 2019 using the terms ''hand pain''

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Section: Hand Osteoarthritismentioning

confidence: 99%

Injection Techniques for Common Chronic Pain Conditions of the Hand: A Comprehensive Review

et al. 2020

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“…Hand OA affects females more than males and this trend appears to be valid for EOA. 6,7,13,24,25 To determine if there is an age and sex bias associated with EOA, we examined age-standardized sex-specific incidence rates of EOA in our statewide cohort from October 2015 -December 2018. We found a significant association between sex and age with EOA.…”

Section: Age-standardized Sex-specific Incidence Rates Of Eoamentioning

confidence: 99%

“…Although hand OA is highly heritable 8 , few genes with large effects have been associated with the onset and progression of hand OA 6,7 , and only three genes have been associated with the EOA phenotype. [21][22][23] The predominant approach to discover hand OA gene variants has been genome-wide association studies (GWAS) [41][42][43][44][45][46] , which relies on large cohorts of cases and controls and well-defined phenotypes.…”

Section: Genetic Involvement In Eoamentioning

confidence: 99%

“…Hand osteoarthritis (OA) is the most prevalent form of OA and is a major cause of disability. [1][2][3][4][5][6][7] It is a heterogeneous disorder with a substantial genetic contribution. 8 Despite significant heritability of hand OA, very few genes and pathways have been discovered that modify the course of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…8 Despite significant heritability of hand OA, very few genes and pathways have been discovered that modify the course of the disease. 6,7 Erosive hand osteoarthritis (EOA)…”

Section: Introductionmentioning

confidence: 99%

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Familial clustering of erosive hand osteoarthritis in a large statewide cohort

Kazmers

Novak

et al. 2020

Preprint

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Objectives: Erosive hand osteoarthritis (EOA) is a severe and rapidly progressing form of osteoarthritis. Its etiology remains largely unknown, which has hindered development of successful treatments. Our primary goal was to test the hypothesis that EOA would demonstrate familial clustering in a large statewide population linked to genealogical records, which would suggest a genetic contribution to the pathogenesis of this condition. Our secondary purpose was to determine the association of potential risk factors with EOA. Methods: Patients diagnosed with EOA were identified by searching medical records from a comprehensive statewide database, the Utah Population Database (UPDB). Affected individuals were then mapped to pedigrees to identify high-risk families with excess clustering of EOA as defined by a Familial Standardized Incidence Ratio (FSIR) of ≥ 2.0. The magnitude of familial risk of EOA in related individuals was calculated using Cox regression models. Association of potential EOA risk factors was analyzed using conditional logistic regression and logistic regression models. Results: We identified 703 affected individuals linked to 240 unrelated high-risk pedigrees with excess clustering of EOA (FSIR ≥ 2.0). The relative risk of developing EOA was significantly elevated in first-degree relatives. There was a significant association with the diagnosis of EOA and age, sex, diabetes, and obesity. Conclusions: Familial clustering of EOA observed in a statewide database indicates a potential genetic contribution to the etiology of the disease. Identification of causal gene variants in these high-risk families may provide insight into the genes and pathways that contribute to EOA onset and progression.

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Relationship Between Body Mass Index and Osteoarthritis for Single and Multisite Osteoarthritis of the Hand, Hip, or Knee: Findings From a Canadian Longitudinal Study on Aging

Badley

Zahid

Wilfong

et al. 2022

Arthritis Care & Research

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Objective To determine whether an apparent association between hand osteoarthritis (OA) and adiposity is explained by the presence of OA at other joint sites. Methods Data from the Canadian Longitudinal Study on Aging, first cycle, comprehensive cohort, were used. Respondents age 45–85 years (n = 18,279) were asked separate questions about doctor‐diagnosed OA in the hand, hip, or knee. Multinomial logistic regression was used to investigate the relationship between all combinations of hand, hip, and knee OA and body mass index (BMI) and waist‐to‐height ratio (WHtR). Results OA was reported by 34.6% of respondents, 28.0% with OA at >1 joint site. Hand OA was not significantly associated with BMI after accounting for OA at other joint sites, with similar findings for WHtR. All joint site combinations containing the knee were strongly associated with BMI, with odds ratios (ORs) ranging from OR 2.92 (95% confidence interval [95% CI] 2.53–3.37) for knee OA only with obesity class I to OR 9.98 (95% CI 7.12–13.88) for multi‐joint knee, hip, hand OA with obesity class II/III. BMI distributions including knee OA were broader and shifted to higher BMI levels than those for hand or hip OA. Conclusion Apparent associations between hand OA and BMI may be explained by concurrent OA at other joint sites. Recognizing that OA is a multi‐joint disease is crucial for studies of the associations of adiposity with OA in a particular joint, especially the hand. The association between knee OA and BMI appears to be distinct from those for OA at other joint sites.

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Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management

Cited by 141 publications

References 239 publications

Injection Techniques for Common Chronic Pain Conditions of the Hand: A Comprehensive Review

Injection Techniques for Common Chronic Pain Conditions of the Hand: A Comprehensive Review

Familial clustering of erosive hand osteoarthritis in a large statewide cohort

Relationship Between Body Mass Index and Osteoarthritis for Single and Multisite Osteoarthritis of the Hand, Hip, or Knee: Findings From a Canadian Longitudinal Study on Aging

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