Ultrasound triggered drug delivery for mitochondria targeted sonodynamic therapy

Chen, MengJia; Xu, Airen; He, Wenyue; Ma, Weiyin; Shen, Song

doi:10.1016/j.jddst.2017.05.009

Cited by 46 publications

(28 citation statements)

References 28 publications

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“…For mitochondria targeted sonodynamic therapy (SDT), using ultrasound and a sonosensitizing chemical substance, Chen et al ( 64 ) developed a liposomal formulation composed of soy lecithin:CHOL : CHOL-anchored 3-carboxypropyl triphenylphosphine bromide (3:0.7:0.3 weight ratio). This formulation was used to encapsulate the sonosensitizer hematoporphyrin monomethyl ether (HMME) ( 64 ). The presence of CHOL-anchored 3-carboxypropyl triphenylphosphine bromide (CHOL-TPP) allows for mitochondria targeting.…”

Section: Triggered Drug Release By Exogenous Stimulimentioning

confidence: 99%

Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment

et al. 2021

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Since more than 40 years liposomes have being extensively studied for their potential as carriers of anticancer drugs. The basic principle behind their use for cancer treatment consists on the idea that they can take advantage of the leaky vasculature and poor lymphatic drainage present at the tumor tissue, passively accumulating in this region. Aiming to further improve their efficacy, different strategies have been employed such as PEGlation, which enables longer circulation times, or the attachment of ligands to liposomal surface for active targeting of cancer cells. A great challenge for drug delivery to cancer treatment now, is the possibility to trigger release from nanosystems at the tumor site, providing efficacious levels of drug in the tumor. Different strategies have been proposed to exploit the outer and inner tumor environment for triggering drug release from liposomes and are the focus of this review.

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Section: Triggered Drug Release By Exogenous Stimulimentioning

confidence: 99%

Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment

et al. 2021

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“…To further improve the targeted delivery and site-specific enrichment of liposomes, Chen et al grafted mitochondrial targeted molecules (3-carboxypropyl) triphenylphosphonium bromide (TPP) onto the surface of HMME-loaded nanoliposomes to achieve a higher accumulation in the mitochondria that were vulnerable to cytotoxic ROS, and finally obtained an improved killing effect of cancer cells through HMME-mediated SDT. [36] In addition to grafting active targeted molecules, some other elements have also been introduced to diversify functionality and consolidate treatment efficiency. For example, Yang et al integrated the HMME sonosensitizer, and targeting folate (FA) molecules onto nanoliposomes with perfluoropentane (PFP) as the core to construct a kind of nanodroplet for targeted effect and acoustic droplet vaporization (ADV) conjointly enhanced Organic sonosensitizers Encapsulated with liposomes HMME@Lipo 1.0 MHz, 0.5 W cm −2 , 3 min [35] HMME@TPP-Lipo 1.0 MHz, 0.5 W cm −2 , 3 min [36] FA-H@NDs 1.…”

Section: Organic-small-molecule Sonosensitizersmentioning

confidence: 99%

“…[36] In addition to grafting active targeted molecules, some other elements have also been introduced to diversify functionality and consolidate treatment efficiency. For example, Yang et al integrated the HMME sonosensitizer, and targeting folate (FA) molecules onto nanoliposomes with perfluoropentane (PFP) as the core to construct a kind of nanodroplet for targeted effect and acoustic droplet vaporization (ADV) conjointly enhanced Organic sonosensitizers Encapsulated with liposomes HMME@Lipo 1.0 MHz, 0.5 W cm −2 , 3 min [35] HMME@TPP-Lipo 1.0 MHz, 0.5 W cm −2 , 3 min [36] FA-H@NDs 1. SDT ( Figure 4A).…”

Section: Organic-small-molecule Sonosensitizersmentioning

confidence: 99%

“…grafted mitochondrial targeted molecules (3‐carboxypropyl) triphenylphosphonium bromide (TPP) onto the surface of HMME‐loaded nanoliposomes to achieve a higher accumulation in the mitochondria that were vulnerable to cytotoxic ROS, and finally obtained an improved killing effect of cancer cells through HMME‐mediated SDT. [ 36 ] In addition to grafting active targeted molecules, some other elements have also been introduced to diversify functionality and consolidate treatment efficiency. For example, Yang et al.…”

Section: Sonosensitizersmentioning

confidence: 99%

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

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“…To overcome these limitations, researchers have begun to focus on stimuli-responsive liposomes. These liposomes can achieve rapid drug release under stimulation by pH [13], ultrasound [14,15], temperature [16], or enzymes [17]. Thermosensitive liposomes (TSL), which can significantly improve the release efficiency of loaded drugs once stimulated by appropriate temperatures, have received extensive attention [18].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Effects of Near-Infrared Multifunctional Liposomes on Cancer Cells

et al. 2020

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Multifunctional theranostic systems are a recent important development of medical research. We combined the characteristics of near-infrared luminescent quantum dots and thermosensitive magnetoliposomes to develop a multifunctional nano-diagnostic material. This system is based on near-infrared magnetic thermosensitive liposomes, which encapsulate drugs and can control drug localization and release. After incubating cancer cells with the liposomes, the state of the cells was analyzed in real time by near-infrared imaging. Cell viability was significantly inhibited by heat treatment or alternating magnetic field treatment, which thus improved the anti-cancer properties of the liposomes. In the future, by combining near-infrared imaging technology and an external high-frequency alternating magnetic field, we could not only detect cancer cells noninvasively but also conduct image-guided treatments for cancer.

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Ultrasound triggered drug delivery for mitochondria targeted sonodynamic therapy

Cited by 46 publications

References 28 publications

Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment

Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Comprehensive Effects of Near-Infrared Multifunctional Liposomes on Cancer Cells

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