Comprehensive Effects of Near-Infrared Multifunctional Liposomes on Cancer Cells

Deng, Yiqing; Huang, Huaying; Chen, Mengxiao; Chen, Gang; Zou, Wangcai; Zhao, Yanqing; Zhao, Qiang

doi:10.3390/molecules25051098

Cited by 7 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13 Nanoformulationsare considered a useful and promising tool for effective treatment of cancer due to reduced toxicity, stability, more loading capacity, higher efficacy, and drug-loaded tolerability in nanoparticles compared to traditional chemotherapy drugs. 14,15 The limitation of a conventional chemotherapeutic drug is minimized by transforming it into a nanoformulation. Nanotechnology immensely provides essential initial diagnosis and bioimaging, multifunction therapies, and drug delivery systems.…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

“…The advantage is not only of small size but properties like the ability to design from multiple materials such as lipids that include SLN (solid lipid nanoparticles) and liposomes, polymers include polymeric nanoparticles (NPs) and inorganic substances like gold NPs. 15,16 Various types of nanoparticles based delivery systems have been developed and also used in clinical diagnosis and therapy. For cancer immunotherapy, the nanoparticles are divided into two types; synthetic and natural nanoparticles.…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

“…Liposomes are suggested to better deliver this drug as it increases therapeutic efficacy and reduces detrimental toxicities. 52,53…”

Section: Paclitaxel (Taxol)mentioning

confidence: 99%

See 2 more Smart Citations

Exploring Liposomes for Lung Cancer Therapy

Shahid

Khan

Ahmad

et al. 2022

Crit Rev Ther Drug Carrier Syst

View full text Add to dashboard Cite

Cancer is referred to as a pleiotropic disease-causing approximately 9.6 million deaths in 2018. Among all cancers, lung cancer was the leading cause of death in 2017, and 12% of fatalities were alone due to lung cancer. The associated risk factors in lung cancer include smoking (80-85%), chronic inflammation in the lungs, COPD, pulmonary fibrosis, environmental and occupational exposure to nickel, arsenic, chromates, etc. Early diagnosed patients' treatment plan includes chemotherapy, immunotherapy, radiotherapy, surgery, and tumor ablation. Many sorts of drug delivery carriers have been used in the past, usually in targeted chemotherapy. Liposomes are spherical shape vesicles containing a lipid bilayer and aqueous core, with potency to encapsulate both hydrophobic and hydrophilic drugs with minimal toxicity. These vesicles have a particle size of 0.02-1000 µm allowing selective passive targeting to the tumor's deeper tissues. Current publications on liposomes highlight their acceptance and best choice among all systems to deliver synthetic and herbal drugs to the lungs. This review focuses on many aspects, which include an in-depth analysis of potential anticancer drugs that have utilized the advantages of liposomes for effective lung carcinomatherapy and devices used to deliver the active agents to the pulmonary tissues. Investigations on ongoing, approved, and failed clinical trials and patents on products related to lung cancer have been highlighted to provide a critical review on the subject.

show abstract

Section: Squamous Cell Carcinomamentioning

confidence: 99%

Section: Squamous Cell Carcinomamentioning

confidence: 99%

See 1 more Smart Citation

Exploring Liposomes for Lung Cancer Therapy

Shahid

Khan

Ahmad

et al. 2022

Crit Rev Ther Drug Carrier Syst

View full text Add to dashboard Cite

show abstract

“…Deng and colleagues [147] recently developed a multicomponent system for diagnosis and treatment of cancers. They combined near infrared luminescence of quantum dots and thermo-sensitivity of magnetic liposomes to encapsulate and control drug localization and release.…”

Section: Encapsulation Of Diagnosticsmentioning

confidence: 99%

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Ngwuluka¹,

Abu-Thabit²,

Uwaezuoke³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

View full text Add to dashboard Cite

Encapsulation, specifically microencapsulation is an old technology with increasing applications in pharmaceutical, agrochemical, environmental, food, and cosmetic spaces. In the past two decades, the advancements in the field of nanotechnology opened the door for applying the encapsulation technology at the nanoscale level. Nanoencapsulation is highly utilized in designing effective drug delivery systems (DDSs) due to the fact that delivery of the encapsulated therapeutic/diagnostic agents to various sites in the human body depends on the size of the nanoparticles. Compared to microencapsulation, nanoencapsulation has superior performance which can improve bioavailability, increase drug solubility, delay or control drug release and enhance active/passive targeting of bioactive agents to the sites of action. Encapsulation, either micro- or nanoencapsulation is employed for the conventional pharmaceuticals, biopharmaceuticals, biologics, or bioactive drugs from natural sources as well as for diagnostics such as biomarkers. The outcome of any encapsulation process depends on the technique employed and the encapsulating material. This chapter discusses in details (1) various physical, mechanical, thermal, chemical, and physicochemical encapsulation techniques, (2) types and classifications of natural polymers (polysaccharides, proteins, and lipids) as safer, biocompatible and biodegradable encapsulating materials, and (3) the recent advances in using lipids for therapeutic and diagnostic applications. Polysaccharides and proteins are covered in the second part of this chapter.

show abstract

“…Они позволяют переносить как липофильные, амфифильные, так и гидрофильные соединения [2], а сродство с бислоем клеточной стенки позволяет осуществлять доставку непосредственно в клетку опухоли. Однако высвобождение лекарств из традиционных липосом происходит медленно и неконтролируемо [3]; при этом в кровотоке такие липосомы могут подвергаться быстрой деградации фагоцитарными клетками ретикулоэндотелиальной системы (РЭС) [1]. Ранее нами было показано положительное влияние липосом на биодоступность лекарственных соединений [4][5][6].…”

Section: Introductionunclassified

Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles

et al. 2020

View full text Add to dashboard Cite

Doxorubicin is one of the widely known and frequently used chemotherapy drugs for the treatment of various types of cancer, the use of which is difficult due to its high cardiotoxicity. Targeted drug delivery systems are being developed to reduce side effects. One of the promising components as vector molecules (ligands) are NGR-containing peptides that are affinity for the CD13 receptor, which is expressed on the surface of many tumor cells and tumor blood vessels. Previously, a method was developed for preparing a composition of doxorubicin embedded in phospholipid nanoparticles with a targeted fragment in the form of an ultrafine emulsion. The resulting composition was characterized by a small particle size (less than 40 nm) and a high degree of incorporation of doxorubicin (about 93%) into transport nanoparticles. When assessing the penetrating ability and the degree of binding to the surface of fibrosarcoma cells (HT-1080), it was shown that when the composition with the targeted fragment was added to the cells, the level of doxorubicin was almost 2 times higher than that of the liposomal form of doxorubicin, i.e. the drug in the system with the targeted peptide penetrated the cell better. At the same time, on the control line of breast adenocarcinoma cells (MCF-7), which do not express the CD13 receptor on the surface, there was not significant difference in the level of doxorubicin in the cells. The data obtained allow us to draw preliminary conclusions about the prospects of targeted delivery of doxorubicin to tumor cells when using a peptide conjugate containing an NGR motif and the further need for its comprehensive study.

show abstract

Comprehensive Effects of Near-Infrared Multifunctional Liposomes on Cancer Cells

Cited by 7 publications

References 46 publications

Exploring Liposomes for Lung Cancer Therapy

Exploring Liposomes for Lung Cancer Therapy

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles

Contact Info

Product

Resources

About