Ultrasound spectroscopy applied to blood coagulation studies

Jacobs, John E.; Malinka, Aleksey; Haque, Papia; Jhabvala, M.

doi:10.1016/0041-624x(76)90105-0

Cited by 13 publications

(5 citation statements)

References 3 publications

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“…6) Most of these available modalities however are not appropriate for continuous and dynamic measurements and monitoring. Due to low cost and real-time capabilities, other alternative feasibility studies with ultrasound techniques were explored, that included spectroscopy, 7) acoustic streaming, 8,9) and ultrasonic shear wave. 10) Furthermore, several previous studies have been carried out with ultrasonic parameters to characterize blood properties [11][12][13][14] and during coagulation.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Blood Properties from Coagulating Blood of Different Hematocrits Using Ultrasonic Backscatter and Attenuation

Huang

Wang

2006

jjap

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The influence of hematocrit on the change of blood properties during coagulating was extensively investigated using ultrasonic integrated backscatter and attenuation. Measurements were performed with porcine blood at hematocrits ranging from 25 to 55% using a 10 MHz transducer. Results showed that both integrated backscatter and attenuation are able to sensitively differentiate various stages of blood properties during coagulating. The slopes of integrated backscatter (Sr, dB/S) and attenuation (αr, dB·cm-1·MHz-1·mS-1) are increased relative to hematocrit. The best fits for Sr and αr as a function of hematocrit (H) equal to Sr=0.0357+1.62e-0.108H and αr=0.0281+0.003H, respectively. Variations of clotting time (Ts) and reaction time (Tα), estimated respectively from ultrasonic integrated backscatter and attenuation, associated with clot formation are also increased with hematocrit. This study demonstrates that blood hematocrit is a substantial factor affecting viscosity and backscattering properties of blood during coagulation capable of being discerned by ultrasonic backscattering and attenuation.

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Section: Introductionmentioning

confidence: 99%

Characterization of Blood Properties from Coagulating Blood of Different Hematocrits Using Ultrasonic Backscatter and Attenuation

Huang

Wang

2006

jjap

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“…Quantitative ultrasound (QUS) imaging has also been investigated in the context of blood clotting analysis. [17][18][19][20][21] Sigel et al 22 showed in vitro that loose fibrin clots backscatter less energy (ie, hypoechoic on B-mode) in comparison with red blood cell-rich clots or dense fibrin clots. Another study highlighted the increase in echogenicity during clotting due to fibrin fiber formation.…”

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confidence: 99%

Shear Wave Elastography and Quantitative Ultrasound as Biomarkers to Characterize Deep Vein Thrombosis In Vivo

Bosio

Zenati

Destrempes

et al. 2021

J of Ultrasound Medicine

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Objective Investigate shear wave elastography (SWE) and quantitative ultrasound (QUS) parameters in patients hospitalized for lower limb deep vein thrombosis (DVT). Method Sixteen patients with DVT were recruited and underwent SWE and radiofrequency data acquisitions for QUS on day 0, day 7, and day 30 after the beginning of symptoms, in both proximal and distal zones of the clot identified on B‐mode scan. SWE and QUS features were computed to differentiate between thrombi at day 0, day 7, and day 30 following treatment with heparin or oral anticoagulant. The Young's modulus from SWE was computed, as well as QUS homodyned K‐distribution (HKD) parameters reflecting blood clot structure. Median and interquartile range of SWE and QUS parameters within clot were taken as features. Results In the proximal zone of the clot, the HKD ratio of coherent‐to‐diffuse backscatter median showed a significant decrease from day 7 to day 30 (P = .036), while the HKD ratio of diffuse‐to‐total backscatter median presented a significant increase from day 7 to day 30 (P = .0491). In the distal zone of the clot, the HKD normalized intensity of the echo envelope median showed a significant increase from day 0 to day 30 (P = .0062). No SWE features showed statistically significant differences over time. Nonetheless, a trend of lower median of Young's modulus within clot for patients who developed a pulmonary embolism was observed. Conclusion QUS features may be relevant to characterize clot's evolution over time. Further analysis of their clinical interpretation and validation on a larger dataset would deserve to be studied.

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“…In addition, the rheological impacts of RBC aggregation on flowing blood have been explored using ultrasound backscattering and Doppler ultrasound [16,17]. Since the ultrasound backscatter depends on the particle structure in tissues, rheological studies have involved liquid blood [7,18] or coagulating blood by measuring the backscatter in vitro [19,20]. The power backscattered from coagulating human whole blood was measured for 24 hours using a 7.5-MHz transducer by Shung et al [21], who found that the backscatter increased by 18.5 ± 1.2 dB (mean ± SD) during the clotting period.…”

Section: Ultrasound Backscattermentioning

confidence: 99%

Untitled

Huang¹

2011

J. Med. Biol. Eng.

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This paper provides a detailed review of the in vitro, in vivo, and clinical applications of ultrasound to understand blood coagulation. The paper focuses on the effect of blood rheology on clotting mechanisms, especially on the use of ultrasound to detect the viscoelastic properties of blood clots. After a short introduction, the paper describes how quantitative ultrasound parameters can be used to study the process of blood coagulation. Ultrasound parameters can be used for tissue characterization, and so the process of blood coagulation can be monitored continuously by measuring the ultrasound backscatter, attenuation coefficient, and velocity. Furthermore, several ultrasound elastography methods including quasi-static strain imaging, shear wave, and acoustic-radiation-force imaging are introduced for measuring the viscoelastic properties of blood clots. The advantages and drawbacks of these ultrasound-based approaches for detecting blood coagulation are discussed. Finally, new areas of research, the clinical application of ultrasound, and areas of potential future developments are presented.

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Ultrasound spectroscopy applied to blood coagulation studies

Cited by 13 publications

References 3 publications

Characterization of Blood Properties from Coagulating Blood of Different Hematocrits Using Ultrasonic Backscatter and Attenuation

Characterization of Blood Properties from Coagulating Blood of Different Hematocrits Using Ultrasonic Backscatter and Attenuation

Shear Wave Elastography and Quantitative Ultrasound as Biomarkers to Characterize Deep Vein Thrombosis In Vivo

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