Ultrasound-guided fine needle aspiration cytology diagnosis of gall bladder lesions with application of WHO histological classification of tumors on cytoaspirate material

Bhartiya, Richa; Mallick, Sujata; Mallik, Mahasweta; Agrawal, Pallavi; Singh, Rashmi; Singh, Ran Vijoy Narayan

doi:10.4103/1755-6783.196595

Cited by 4 publications

(9 citation statements)

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“…In our study, majority of the patients were females which correlated with the study of GB masses conducted by Iqbal et al 19 who had a male to female ratio of 1:3.5 and also with a study by Evarisalin et al 20 In the present study, we found that the age ranges from 34 to 85 years and mean age was 63.3 years which is similar to a study by Handa et al which observed their age range of 24 to 84 years and a mean age of 52 years 21 . Similar results were observed in a study by Evarisalin et al 20 The predominant lesions were found to be malignant over the benign and inflammatory lesions which correlated with the studies conducted by Bhartiya et al 22 and Evarisalin et al 20 Under the malignant category, adenocarcinoma(76.6%) was the most common morphologic pattern to be diagnosed which was similar to a study by Yadav et al 23 (86.7%) and 65% by Evarisalin et al 20 …”

Section: Discussionsupporting

confidence: 92%

Diagnostic role of fine needle aspiration cytology (FNAC) in the evaluation of gall bladder lesions: an institutional experience

Selhi

Singh

Jain

et al. 2020

Diagnostic Cytopathology

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Background: Carcinoma of the gall bladder is the most common malignancy of the biliary tract. Ultrasonography guided Fine Needle Aspiration Cytology (FNAC) plays a crucial role in early detection of gall bladder (GB) lesions. Early diagnosis of GB lesions is a necessity in view of rising trend in GB carcinoma related mortality in India. The aim of this study is to determine the diagnostic accuracy of pre-operative ultrasonography guided FNAC in the diagnosis of GB masses. Methods: This was a retrospective observational study performed at a tertiary care university hospital over a period of one and a half years. A total of 47 patients with clinico-radiological suspicion of GB malignancy were subjected to USG guided FNA. 20 of these patients underwent diagnostic Trucut biopsy in addition to FNA. Results: Forty-one out of 47 patients analyzed were positive for malignancy with female preponderance; MF ratio of 0.6:1. There were 29 females (61.8%) and 18 males (38.2%) in the range of 34 to 85 years. Cytomorphology was inconclusive for malignancy in two patients and unsatisfactory in one case. Two were labeled as chronic cholecystitis and one as acute cholecystitis. Adenocarcinoma was the most common malignancy found in 36 patients (76.6%). Conclusion: USG guided FNAC is a rapid, safe and successful diagnostic procedure with high sensitivity for diagnosis of GB lesions. In the present scenario of increasing incidence of GB malignancy, FNAC has proved to be a useful first choice of investigation in the detection of GB lesions.

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Section: Discussionsupporting

confidence: 92%

Diagnostic role of fine needle aspiration cytology (FNAC) in the evaluation of gall bladder lesions: an institutional experience

Selhi

Singh

Jain

et al. 2020

Diagnostic Cytopathology

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“…[ 21 ] In this study, the male to female ratio of GBC was 1:1.9, whereas in other Indian studies, it was found to be 1:4.2. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] In this regard, the USG-FNAC approach is a safe, quick, and cost-effective preoperative diagnostic tool for precise diagnosis of gallbladder lesions. [ 8 9 10 11 12 13 ] However, this the procedure is still avoided as a first-line diagnostic tool at many health care centers due to lack of facilities, expertise, and the reluctance of the concerned clinician because of fear of procedure-related complications and low diagnostic accuracy. Hence, the diagnostic utility, standard cytological terminology, and nomenclature systems used for gallbladder lesions on FNAC are lacking.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of ultrasound-guided fine-needle aspiration cytology in gall bladder lesions: an experience from a tertiary care cancer center in Eastern India

Rout¹,

Hota

Dash³

et al. 2021

J Cytol

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Introduction: Gallbladder cancer (GBC) is the most common malignancy, representing 80–95% of biliary tract cancers. Although ultrasonography-guided fine-needle aspiration cytology (USG-FNAC) has emerged as an effective diagnostic the tool for the precise diagnosis of gallbladder lesions, data on its diagnostic utility and cytomorphological categorization of gallbladder lesions are lacking. Aims: To study the diagnostic utility of USG-FNAC in gallbladder lesions. Materials and Methods: This study was the conducted prospectively on patients who came with clinical and radiological evidence of gallbladder space-occupying lesion and then advised to USG-FNAC over 2 years and 6 months from January 2018 to June 2020. Results: A total of 314 cases were included. The mean age was 56 years, with a range of 17–88 years. Women predominated over men (Male:Female = 1:2.3). Primary adenocarcinoma of the gallbladder was most common. On cyto-histological correlation, the sensitivity, specificity, and diagnostic accuracy of USG-FNAC of gallbladder lesions were found to be 98.82, 87.23, and 96.3%, respectively. Conclusion: The USG-FNAC of gallbladder lesion was found to be an easy, quick, cost-effective, and presumptive diagnostic procedure. It should be opted as an initial preoperative diagnostic modality in high incidence areas to avoid inappropriate management with unnecessary morbidity and cost. Moreover, a close cytological examination of the architectural pattern and the cytomorphological features would help in the sub-typing and prognosticating the tumor.

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“…Carcinoma of the GB is the most frequent neoplasm of the biliary tract. 1,2 Early symptoms of this disease are vague. Patient usually presents late when the disease is well established or reaches an inoperable state.…”

Section: Introductionmentioning

confidence: 99%

“…It has 10 times more common incidence in North India than in South India. 1 Incidence of GB cancer shows an increasing trend in North eastern part of India. Dr. B. Borooah Cancer Institute Guwahati being the tertiary level cancer centre in this region it caters most of the patients from North eastern India.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound guided fine needle aspiration cytology of gall bladder mass and mural thickening: a radio-pathological correlation

Barman¹,

Bujarbaruah²,

Choudhury³

et al. 2019

Int J Res Med Sci

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Background: Carcinoma of the gall bladder (GB) is the commonest malignancy of the biliary tract. Ultrasound (US) guided Fine Needle Aspiration Cytology (FNAC) plays a major role in early detection of malignancy in a suspicious GB lesion. The aim of this study was to evaluate the safety and diagnostic accuracy of US guided FNAC in detection of GB malignancy, to find the association of gall stones with GB malignancy, to study the ultrasound pattern of GB malignant mass and demographic profile of the disease in North eastern India.Methods: The study was conducted retrospectively in Dr. B. Borooah Cancer Institute, Guwahati from January 2016 to December 2017. A total number of 173 patients suspected to have GB malignancy were subjected to US guided FNAC.Results: Total 161 patients were positive for malignancy with significant female majority. There were 124 female (77.02%) and 37 males (22.98%) in the range of 29 to 82 years. Male female ratio was 1:3.5. One was diagnosed as xanthogranulomatous cholecystitis and another was chronic cholecystitis. FNAC remained inconclusive in 2 patients. There was no major procedure related complication. Adenocarcinoma was the most common malignancy found in 146 patients (98.68%). Cholelithiasis was associated in 88.19% of malignant lesions.Conclusions: US-guided FNAC is a safe, highly accurate and reliable procedure for early detection of GB malignancy.

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Ultrasound-guided fine needle aspiration cytology diagnosis of gall bladder lesions with application of WHO histological classification of tumors on cytoaspirate material

Cited by 4 publications

References 0 publications

Diagnostic role of fine needle aspiration cytology (FNAC) in the evaluation of gall bladder lesions: an institutional experience

Diagnostic role of fine needle aspiration cytology (FNAC) in the evaluation of gall bladder lesions: an institutional experience

Diagnostic utility of ultrasound-guided fine-needle aspiration cytology in gall bladder lesions: an experience from a tertiary care cancer center in Eastern India

Ultrasound guided fine needle aspiration cytology of gall bladder mass and mural thickening: a radio-pathological correlation

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