Ultrasound Contrast for Hepatic Tumors Using IDE Particles

Parker, Kevin J.; Baggs, Raymond B.; Lerner, R M; Tuthill, T.A.; Violante, Michael R.

doi:10.1097/00004424-199010000-00013

Cited by 22 publications

(4 citation statements)

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“…Several injectable US agents have been developed and hold promise for increasing the sensitivity of ultrasound for detecting metastatic disease. [29][30][31][32][33][34][35][36][37][38] The agents either enhance blood flow visualization within or around lesions or enhance the visualization of normal parenchyma. Although US contrast agents show promise in regard to the detection and characterization of metastatic disease, their role in the evaluation of patients with metastases awaits the results of scientific investigation.…”

Section: Seminars In Liver Disease/volume 21 Number 2 2001mentioning

confidence: 99%

Evaluation of the Liver for Metastatic Disease

Paulson¹

2001

Semin Liver Dis

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Metastatic disease of the liver accounts for the vast majority of detected liver masses. In patients with suspected metastatic disease, cross-sectional imaging with ultrasound (US), computed tomography (CT), or magnetic resonance imaging (MRI) is critical. In the group of patients undergoing evaluation for hepatic surgery, it is even more important to optimize techniques to detect and localize metastatic disease. With improvements in technology and contrast agents, there are several approaches to imaging the liver for metastatic disease. The approach will vary by institution. This article will attempt to provide an overview of the general issues relevant to imaging metastatic disease, highlight the advantages and disadvantages of one modality compared to another, and illustrate the appearance of metastases using US, CT, and MRI.

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Section: Seminars In Liver Disease/volume 21 Number 2 2001mentioning

confidence: 99%

Evaluation of the Liver for Metastatic Disease

Paulson¹

2001

Semin Liver Dis

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“…These include free and encapsulated gas bubbles, colloidal suspensions, emulsions (including dense spherical particles of iodipimide ethyl ester with diameters between 0.05 and 3.0 μιη [627]) and aqueous solutions. They operate through backscatter, attenuation and sound speed contrast.…”

Section: (Ii) Continuous-wave and Millisecondmentioning

confidence: 99%

Effects and Mechanisms

Leighton

1994

The Acoustic Bubble

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“…Alternative solutions based on polymeric nanocapsules with a liquid perfluorooctyl bromide core [3,14] or a perfluorocarbon nanoparticle emulsion [15] have also been proposed to develop MRI/UI dual-mode CAs, even if the solid, incompressible nanoparticles significantly reduce the ultrasound backscattering efficiency (i.e. the CAs' echogenicity) [16,17]. …”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance and ultrasound contrast imaging of polymer-shelled microbubbles loaded with iron oxide nanoparticles

et al. 2016

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Dual-mode contrast agents (CAs) have great potential for improving diagnostics. However, the effectiveness of CAs is strictly related to both the solution adopted to merge the two agents into a single probe unit, and the ratio between the two agents. In this study, two dual-mode CAs for simultaneous magnetic resonance imaging (MRI) and ultrasound imaging (UI) were assessed. For this purpose, different densities of superparamagnetic iron oxide nanoparticles (SPIONs) were anchored to the external surface of polymer-shelled microbubbles (MBs) or were physically entrapped into the shell. In vitro static and dynamic experiments were carried out with a limited concentration of modified MBs (106 bubbles ml−1) by avoiding destruction during UI (performed at a peak pressure lower than 320 kPa) and by using a low-field MRI system (with a magnetic flux density equal to 0.25 T). Under these conditions, different imaging techniques, set-up parameters and SPION densities were used to achieve satisfactory detection of the CAs by using both UI and MRI. However, when the SPION density was increased, the MRI contrast improved, whereas the UI contrast worsened due to the reduced elasticity of the MB shell. For both UI and MRI, MBs with externally anchored SPIONs provided better performance than MBs with SPIONs entrapped into the shell. In particular, a SPION density of 29% with respect to the mass of the MBs was successfully tested.

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Ultrasound Contrast for Hepatic Tumors Using IDE Particles

Cited by 22 publications

References 0 publications

Evaluation of the Liver for Metastatic Disease

Evaluation of the Liver for Metastatic Disease

Effects and Mechanisms

Magnetic resonance and ultrasound contrast imaging of polymer-shelled microbubbles loaded with iron oxide nanoparticles

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