Ultrasound-assisted synthesis of β -amino ketones via a Mannich reaction catalyzed by Fe 3 O 4 magnetite nanoparticles as an efficient, recyclable and heterogeneous catalyst

Saadatjoo, Naghi; Golshekan, Mostafa; Shariati, Shahab; Azizi, Parastou; Nemati, Firouzeh

doi:10.1016/j.arabjc.2012.11.018

Cited by 24 publications

(9 citation statements)

References 20 publications

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“…The synthesis of Fe 3 O 4 nanoparticles, following the precipitated method, , was carried out in accordance with our previous work. To prepare the stock solution of ferrous and ferric chloride, 6.3 g of FeCl 3 ·6H 2 O, 4.0 g of FeCl 2 ·4H 2 O, and 1.7 mL of HCl (12 mol L –1 ) were dissolved in 50 mL of deionized water in a beaker.…”

Section: Methodsmentioning

confidence: 99%

Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Hosseini,

Abdouss,

Golshekan

2023

ACS Omega

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This article presents a comprehensive study of the development of a novel nanocomposite comprising core−shell Fe 3 O 4 @MCM-41 with superparamagnetic properties and hydroxyapatite (HAp). The nanocomposite serves as a pH-responsive nanocarrier, offering an efficient injectable dosage for teriparatide (PTH (1−34)) delivery. The aim is to address the limitations associated with druginduced side effects, precautionary measures, and frequent injections. The nanocomposites, as prepared, were characterized using techniques including X-ray diffraction, Fourier transform infrared, zeta potential, dynamic light scattering, VSM, scanning electron microscopy, and transmission electron microscopy. The nanocomposites' average crystallite diameter was determined to be 27 ± 5 nm. The hydrodynamic size of the PTH (1−34)-loaded nanocarrier ranged from 357 to 495 nm, with a surface charge of −33 mV. The entrapment and loading efficiencies were determined to be 73% and 31%, respectively. All of these findings collectively affirm successful fabrication. Additionally, in vivo medication delivery was investigated using the HPLC method, mirroring the in vitro tests. Utilizing the dialysis approach, we demonstrated sustained-release behavior. PTH (1−34) diffusion increased as the pH decreased from 7.4 to 5.6. After 24 h, drug release was higher at acidic pH (88%) compared to normal pH (43%). The biocompatibility of the PTH (1−34)-loaded nanocarrier was assessed using the MTT assay employing the NIH3T3 and HEK-293 cell lines. The results demonstrated that the nanocarrier not only exhibited nontoxicity but also promoted cell proliferation and differentiation. In the in vivo test, the drug concentration reached 505 μg within 30 min of exposure to the magnetic field. Based on these findings, the Fe 3 O 4 @MCM-41/HAp/PTH (1−34) nanocomposite, in combination with a magnetic field, offers an efficient and biocompatible approach to enhance the therapeutic effect of osteogenesis and overcome drug limitations.

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Section: Methodsmentioning

confidence: 99%

Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Hosseini,

Abdouss,

Golshekan

2023

ACS Omega

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“…Thus, one-pot three-component reactions of aryl or cycloalkyl ketones with aryl aldehydes and aryl amines in ethanol at room temperature under catalytic conditions yielded the respective b-aminoketones 14a-q (Scheme 7). [85][86][87][88][89][90][91][92] The sequence of these reactions is related to Mannich-type reactions in a green protocol. The nanocatalyst activated the aldehyde ketone to nucleophilic attack by the amine group, and consequently enabled the enolization of the aryl or cycloalkyl ketones in the condensation.…”

Section: Catalyzed Mannich Reactionsmentioning

confidence: 99%

Recent progress in the chemistry of β-aminoketones

Hammouda

Elattar

2022

RSC Adv.

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“…Saadatjoo et al . demonstrated ultrasound‐assisted one‐pot three‐component Mannich reaction between cyclohexanone ( 6 ), primary amines ( 7 ) and various aldehydes ( 1 ) to obtain the corresponding β‐amino carbonyl compounds ( 8 ) in the presence of a catalytic amount of magnetically separable γ‐Fe 3 O 4 nanoparticles in ethanol at room temperature (Table ).…”

Section: Nano‐particles Catalyzed Ultrasound‐assisted Organic Transfomentioning

confidence: 99%

Ultrasound and Nano‐Catalysts: An Ideal and Sustainable Combination to Carry out Diverse Organic Transformations

Banerjee¹

2019

ChemistrySelect

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The nano-sized catalysts are more effective than the traditional homogeneous or heterogeneous catalysts in bulk state. On the other hand, ultrasound-assisted strategy offers several advantages such as higher reaction rates, better yields, cost effective, environmentally benign as compared to traditional methods.Therefore, a fruitful combination of nano-catalyst and ultrasound is one of the effective tools to carry out diverse organic transformations. The present review deals with the latest developments on various nano-particles catalyzed organic synthesis under the influence of ultrasonic irradiation.

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Ultrasound-assisted synthesis of β -amino ketones via a Mannich reaction catalyzed by Fe 3 O 4 magnetite nanoparticles as an efficient, recyclable and heterogeneous catalyst

Cited by 24 publications

References 20 publications

Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Recent progress in the chemistry of β-aminoketones

Ultrasound and Nano‐Catalysts: An Ideal and Sustainable Combination to Carry out Diverse Organic Transformations

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Ultrasound-assisted synthesis of β -amino ketones via a Mannich reaction catalyzed by Fe 3 O 4 magnetite nanoparticles as an efficient, recyclable and heterogeneous catalyst

Cited by 24 publications

References 20 publications

Hydroxyapatite Incorporated with Fe3O4@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Hydroxyapatite Incorporated with Fe3O4@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Recent progress in the chemistry of β-aminoketones

Ultrasound and Nano‐Catalysts: An Ideal and Sustainable Combination to Carry out Diverse Organic Transformations

Contact Info

Product

Resources

About

Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration