Ultrasound and deep eutectic solvents: An efficient combination to tune the mechanism of steviol glycosides extraction

Milani, Gualtiero; Vian, Maryline Abert; Cavalluzzi, Maria Maddalena; Franchini, Carlo; Corbo, Filomena; Lentini, Giovanni; Chémat, Farid

doi:10.1016/j.ultsonch.2020.105255

Cited by 35 publications

(21 citation statements)

References 28 publications

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Section: Resultsmentioning

confidence: 99%

“…The molar ratios of the DES forming compounds in each tested DES are listed in Table 1. The lower activity coefficient of the tested HBA and HBD implies higher compound solubility [23,26,29]. Figure 2 shows that there are ten different HBA with 20 HBD that can form different types of DES-from apolar to polar.…”

Section: Des Selection For Optimal Extraction Of Polyphenols From Grape Pomacementioning

confidence: 99%

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COSMOtherm as an Effective Tool for Selection of Deep Eutectic Solvents Based Ready-To-Use Extracts from Graševina Grape Pomace

et al. 2021

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The aim of this work is to develop an industrially suitable process for the sustainable waste disposal in wine production. The proposed process involves the development of an environmentally friendly method for the isolation of biologically active compounds from Graševina grape pomace according to the green extraction principles, in order to obtain a ready-to-use extract. In this process, deep eutectic solvents (DES) were used as extraction solvents. Aiming to save time in selecting the optimal DES that would provide the most efficient Graševina pomace polyphenols extraction, the user-friendly software COSMOtherm was used and 45 DES were screened. Moreover, the prepared extracts were chemically and biologically characterized to confirm their safety for human application. Computational and experimental results proved the applicability of COSMOtherm in the selection of the optimal DES for the environmentally friendly preparation of the ready-to-use extract from Graševina grape pomace with expected application in the cosmetic industry.

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Section: Resultsmentioning

confidence: 99%

Section: Des Selection For Optimal Extraction Of Polyphenols From Grape Pomacementioning

confidence: 99%

COSMOtherm as an Effective Tool for Selection of Deep Eutectic Solvents Based Ready-To-Use Extracts from Graševina Grape Pomace

et al. 2021

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“…is formed. The experimental procedure may be accelerated with ultrasounds [31] microwaves. [32] The procedure is very simple and does not produce by‐products, so it may be considered an environmentally friendly synthesis since there is no waste and no emissions and the atom economy [4] is 100 %, since all the initial atoms are included in the final mixture.…”

Section: Preparation and Properties Of Desmentioning

confidence: 99%

Deep Eutectic Solvents and Multicomponent Reactions: Two Convergent Items to Green Chemistry Strategies

Calvo‐Flores

Mingorance-Sánchez

2021

ChemistryOpen

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One of the highlights of green chemistry is the development of techniques and procedures with low environmental impact. In the last years, deep eutectic solvents (DES) have become an important alternative to conventional organic solvents. For a period ionic liquids have provoked remarkable interest, but they have been displaced by DES because they show easier preparation methods, lower prices, many of them are biode-gradable and compatible with biological systems. In addition, they show adjustable physicochemical properties, high thermal stability, low volatility and are compatible with water. In this paper is reviewed the state of the art of the use of DES paying special attention to the role of reaction media in organic synthesis.

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“…Replacing the extraction solvent by alcohol solution can modify the composition of the extract and produce a higher clarity (Martins, et al, 2016), but it also significantly increases the production cost, and the downstream purification is still required. Innovative extraction technology including pressurised hot water extraction (Kovačević, et al, 2018b) and deep eutectic solvents (Milani, et al, 2020) can also produce the extract of high SG and low impurity content; thus, they are promising alternatives to aqueous extraction once the commercial equipment is available. Membrane technologies can effectively purify stevia extract (Mondal, et al, 2012;Das, et al, 2015;Dıáz-Montes, et al, 2020), however, the SGs recovery is only about 40~50%, and the phenolic compounds cannot be completely isolated.…”

Section: Comparison Of the Two-step Technology With The Other Approachesmentioning

confidence: 99%

Purification of stevia extract by chitosan precipitation and reversed‐phase chromatography

Zhang

Xiao

Liu

et al. 2021

Int J of Food Sci Tech

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To improve the shortness of the current purification technology of steviol glycosides (SG) extract, a twostep purification procedure consisting of chitosan precipitation and reversed-phase chromatography (RPC) was investigated. The impurity-to-SG ratio in the SG extract obtained from non-destructive soaking was 5:1~6:1. It was found that 80.90% of the impurities could be removed by RPC using 20% (v/v) ethanol solution as the eluent with a high SG recovery of 96.98%. When 25% ethanol was applied, the SG recovery was reduced to 71.23%. An adsorption test using D280 anionic resin suggested that the impurities were negatively charged; thus, chitosan was used to co-precipitate the impurities. An optimal decolourisation result of~70% was obtained at 0.06 gÁg −1 (w/w, to solids in extract) chitosan addition, shaking at 28°C for 1 h. Afterwards, the extract was further purified by RPC. The total removal rate of impurities was increased to 91.20%, and the SG recovery was 85.15%.

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Ultrasound and deep eutectic solvents: An efficient combination to tune the mechanism of steviol glycosides extraction

Cited by 35 publications

References 28 publications

COSMOtherm as an Effective Tool for Selection of Deep Eutectic Solvents Based Ready-To-Use Extracts from Graševina Grape Pomace

COSMOtherm as an Effective Tool for Selection of Deep Eutectic Solvents Based Ready-To-Use Extracts from Graševina Grape Pomace

Deep Eutectic Solvents and Multicomponent Reactions: Two Convergent Items to Green Chemistry Strategies

Purification of stevia extract by chitosan precipitation and reversed‐phase chromatography

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